DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and Clip2

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_068837.2	Gene:	Clip2 / 29264	RGDID:	62019	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	1329	Identity:	325/1329 - (24%)
Similarity:	569/1329 - (42%)	Gaps:	375/1329 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRP 74
            |......||| ..|..|:.:|       |.:.:.:.|..|.|...:...|||.|:|.:||:
  Rat    11 GRGGKHSSPV-GRPSIGSASS-------SVVASASGSKEGSPLHKQASGPSSAGATTTVSE---- 63

  Fly    75 CCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQI 139
                   |.||...|.      .||.|.                   .|::|:|||:.|.:||.:
  Rat    64 -------KPGPKAAEV------GDDFLG-------------------DFVVGERVWVNGVKPGVV 96

  Fly   140 AFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLA-----GAQT 199
            .::|:|.||.|:|||||||:|.|||||.|.|.|||:|...:|||:|.::||..|.|     .|.:
  Rat    97 QYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPAAEGSGSDAHS 161

  Fly   200 PTSPLAKSSPDRSRTVSPTAS-----IRSSMLRSP-GIGGKNG---------------MAVGDRV 243
            ..|..|::....|.|.:|..:     :|.|:|.|. ..|.::|               :.:||||
  Rat   162 VESLTAQNLSLHSGTATPPLTGRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGDKDLHLGDRV 226

  Fly   244 IVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV-- 306
            :|.   |::.|::||:|||.||.|.|||||||||.|||||.|...|||:|.||:|:|.||.||
  Rat   227 LVG---GTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIR 288

  Fly   307 ----SLSPS-SKKTR-----LSRTGSRESLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKPIL 360
                |.||: :|||:     :|......|.:||.:::|:|::...| .|.......||...:.|.
  Rat   289 IGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKIS 353

  Fly   361 ATPKSQFSMQDLLREKQQHVEKLMVERDLDRED---AQNQALQLQKNINEVIIFTDTMYAPLPYA 422
            .|.    ::|:.|:|||||:|:|:.||||:|.:   |.:...:::|.|
  Rat   354 GTT----ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI----------------- 397

  Fly   423 DRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQ 487
                       :.:|...:|::
  Rat   398 -----------ALLKAQHEQYV------------------------------------------- 408

  Fly   488 PHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQS 552
            ....:|.|:|: ..|....|:|        |:|.:.|:.||:|.|:||..::|......:|..|:
  Rat   409 AEAEEKLQRAR-LLVENVRKEK--------VDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 464

  Fly   553 QVYKEKIHDLE-SKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVES----- 611
            |:...:|.:|| |.:.:...|...|:.:....|.:  .|.:..:.:|:|::::::.|:|.
  Rat   465 QLEHARIGELEQSLLLEKAQAERLLRELADNRLTT--VAEKSRVLQLEEELSLRRGEIEELQHCL 527

  Fly   612 -----RIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL--EKFSLSECGIENLRRELELLK 669
                 ..|:..|..:.||     |.|::.:...| ..:|..|  :|:   |..::..:.|::.|:
  Rat   528 LQSGPPPADHPEAAETLR-----LRERLLSASKE-HQRDSTLLQDKY---EHMLKTYQTEVDKLR 583

  Fly   670 EENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECE-ILQTEVRMRD 733
            ..|||.|||. |:...|:.:.:.|.:.|   :.|.|:..|||.|:.....::.: .|.:....:.
  Rat   584 AANEKYAQEV-ADLKAKVQQATTENMGL---MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 644

  Fly   734 EQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLND 798
            ::|.||...::.:..:..::..:..|..|:           .|.:...|||.::.|.|.|
  Rat   645 KEIGELKALVEGIKMEHQLELGNLQAKHDL-----------ETAMHGKEKEGLRQKLQEA----- 693

  Fly   799 KEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQ 863
                :::::.|:|..               :.|||:::.:.:|     ||::.|.:..::::.:|
  Rat   694 ----QEELAGLQQHW---------------RAQLEEQASQHRL-----ELQEAQDQCRDAQLRVQ 734

  Fly   864 EIKAQNTQKDFELVESGESLKKLQQQL---EQKTLGHEKLQAALEELKKEKETIIKEK----EQE 921
            |::.    .|.|.....::::.|::|:   |:|.|.:|.||.|..:.::|.|. ::||    |..
  Rat   735 ELEG----LDVEYRGQAQAIEFLKEQISLAEKKMLDYEMLQRAEAQSRQEAER-LREKLLVAENR 794

  Fly   922 LQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQ 986
            ||.::|..:...|  .|::                        .:::|:.|.:.:||   ::..|
  Rat   795 LQAVESLCSAQHS--HVIE------------------------SNDLSEEKIRMKET---VEGLQ 830

  Fly   987 SNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAA 1051
            ..|..:.|::.|              |..|:..|:::|...:....|....::|..|:.....|.
  Rat   831 DKLNKRDKEVAA--------------LTSQMDMLRAQVSALENKCKSGEKKIDSLLKEKRRLEAE 881

  Fly  1052 LEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKA 1116
            ||.|::                           :...:|...:|.
  Rat   882 LEAVSR---------------------------KTHDASGQLVHI-------------------- 899

  Fly  1117 DAWSQEMLQKEKELQELRQQLQDSQD---------SQTKLKAEGERKEKSFEESIKNLQEEVTKA 1172
               |||:|:||:.|.|||..|.::..         |:...|||...||:..::.|:.|:|::|..
  Rat   900 ---SQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 961

  Fly  1173 KTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIA-----DLKTLVEAIQVAN--- 1229
            ..|. .||...:.::.|.....|:  ..||| :.:::|||.:.|     .::.||||::..:
  Rat   962 DKEK-SLSEQKRYSLIDPASAPEL--LRLQH-QLVSTEDALRDALDQAQQVERLVEALRGCSDRT 1022

  Fly  1230 ---ANISATNAELSTVLEVLQAEKSETNH 1255
               :|..:.|.    :.:..:|.|.|..|
  Rat  1023 QTISNSGSANG----IHQPDKAHKQEDKH 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	25/107 (23%)
		CAP_GLY	125..189	CDD:396049	35/63 (56%)
		CAP_GLY	239..306	CDD:396049	40/66 (61%)
		SMC_prok_B	<546..912	CDD:274008	80/382 (21%)
		Smc	734..1591	CDD:224117	108/549 (20%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
Clip2	NP_068837.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		21/79 (27%)
		CAP_GLY	82..146	CDD:396049	35/63 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..216		2/19 (11%)
		CAP_GLY	222..286	CDD:396049	40/66 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..340		7/25 (28%)
		Smc	<357..1016	CDD:224117	182/895 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1022..1047		5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3141
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110101at2759
OrthoFinder	1	1.000	-	-		FOG0002895
OrthoInspector	1	1.000	-	-		otm44494
orthoMCL	1	0.900	-	-		OOG6_104816
Panther	1	1.100	-	-	O	PTHR18916
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2251
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830