DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and Dctn1

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_077044.2	Gene:	Dctn1 / 29167	RGDID:	62038	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	1568	Identity:	314/1568 - (20%)
Similarity:	579/1568 - (36%)	Gaps:	491/1568 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 TDNSSAVLT-ANTEQFIIGQRV-WLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGK 171
            |.:.|.:.| |:.....:|.|| .:|....|.:|::|.|.||.|:|.||:|||..|||||.|.|:
  Rat    12 TPSGSRMSTEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGR 76

  Fly   172 RYFQCEPKRGIFSRLTRLTTYPLAGAQTPTSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKNG 236
            :||.|:...|||.|.:::..:. .||.| |||   .:||.|         .|.:|:..|
  Rat    77 KYFTCDEGHGIFVRQSQIQVFE-DGADT-TSP---ETPDSS---------ASKILKREG------ 121

  Fly   237 MAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFV 301
                      :...::...||.|                                  |||.   .
  Rat   122 ----------ADAAAKTSKLRGL----------------------------------KPKK---A 139

  Fly   302 PIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQ 366
            |.|:.:.:...|.||.:.||.....:|:|...|.:....|       ..:.|||.:..||.|
  Rat   140 PTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGELS-------SSEPSTPAQTPLAAP--- 194

  Fly   367 FSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPS 431
                                                      ||
  Rat   195 ------------------------------------------II--------------------- 196

  Fly   432 KKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQ 496
                                          ||.|..:..||       .||...      .|:::
  Rat   197 ------------------------------PTPALTSPGAA-------PPLPSP------SKEEE 218

  Fly   497 AKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHD 561
            .               |:|::.:||..|:..|.|..|.:..:.|.:        :.::..|::.:
  Rat   219 G---------------LRAQVRDLEEKLETLRLKRSEDKAKLKELE--------KHKIQLEQVQE 260

  Fly   562 LESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLREN 626
            .:||                         :||:.|.||.::    ||......|.||.::|..|.
  Rat   261 WKSK-------------------------MQEQQADLQRRL----KEARKEAKEALEAKERYMEE 296

  Fly   627 VKYLNE--QIATLQSELV-SKDEAL--EKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRK 686
            :....:  ::|||..|:. .:.|:|  |..:|.| .::.|..:||:||.|.|::..:..|. :.:
  Rat   297 MADTADAIEMATLDKEMAEERAESLQQEVEALKE-RVDELTTDLEILKAEIEEKGSDGAAS-SYQ 359

  Fly   687 LAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLN 751
            |.:...:..||...|..::..|.|.:.|.|.       ||..:..:::::..:.||.:
  Rat   360 LKQLEEQNARLKDALVRMRDLSSSEKQEHVK-------LQKLMEKKNQELEVVRQQRE------- 410

  Fly   752 VQKADSSALDDMLRLQKEGTEEKSTLLE-KTEKELVQSKEQAAKTLNDKE-QLEKQISDLKQLAE 814
                         |||:|.::.:||:.| |.:.:.....|:..:.|.|:. .||:::.:|::...
  Rat   411 -------------RLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 462

  Fly   815 QEKLVREMTENAINQIQLEKESIEQQLALK-QNELEDFQKKQSESEVHLQEIKAQNTQKDFELVE 878
            ..:.:.||.:      :|::.:.|.:|.|: |.::...:.::::..|.    .||.|..|::
  Rat   463 DLEAMNEMND------ELQENARETELELREQLDMAGARVREAQKRVE----AAQETVADYQ--- 514

  Fly   879 SGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQ---ELQQLQSKSAESESALKVVQ 940
              :::||.:|     ...|  ||....||..::|..::.::|   |....:.|.||:::..|.::
  Rat   515 --QTIKKYRQ-----LTAH--LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIE 570

  Fly   941 VQLEQLQQQAAASGEEGSKTVAKLHDEISQ-----------------------LKSQAEETQSEL 982
            ::|.|:  :.|.:....|...|.:.|...:                       ::.||:|
  Rat   571 MELRQM--EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE----- 628

  Fly   983 KSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEA 1047
               :.:|.....:.....|:..|:...:..|:..::.|::.:...:.|||.|..||..|...|..
  Rat   629 ---KFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYP 690

  Fly  1048 ANAA--------LEKVNKEYAESRAEASDLQDKVK--EITDTLHAELQAERSSSS-ALHTKLSKF 1101
            ..:|        :|.::|:..:.......|...:|  :...::|...|.|.|:.. |.|.|.::
  Rat   691 EMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEESTMQLADHIKFTQ- 754

  Fly  1102 SDEIATGHKELTSKADAWSQEM------LQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEE 1160
                        |..|..|.|:      ||..:|..::...|:|.:.|.:.::           :
  Rat   755 ------------SALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIR-----------Q 796

  Fly  1161 SIKNLQEEV--TKAKTENLELSTGTQT--TIKDLQERLEITNAELQHKEKMASEDAQKIADLKTL 1221
            ..|.::..:  |.|......|:.|:|.  |:.|.::.|....|.||   ::|:..||.||.|..
  Rat   797 FCKKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQ---EVAAAAAQLIAPLAE- 857

  Fly  1222 VEAIQVA-------NANISATNAELSTVLEVLQAEKS---ETNHIFELFEMEADMNSERLIEK-- 1274
            .|.:.||       .|:.....:..|:..|.|:...|   .|.:.......|.:.::||...|
  Rat   858 NEGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCSILISTMNKLATAMQEGEYDAERPPSKPP 922

  Fly  1275 -----VTGIKEELKETH---LQLDERQKKFEELEEKLK-----------QAQQSEQKLQQESQTS 1320
                 ...::.|:.:..   |:|::|:...:||::.||           :....|:||...::.:
  Rat   923 PVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDA 987

  Fly  1321 KEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQD 1385
            .|::.::|..|:|.|..:::||:..:...:.::.....:||:.|:|.
  Rat   988 DERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKTELK------------------ 1034

  Fly  1386 QLLESQKKE----------KQLQEEAAKLSGELQQ----------VQEANGDIKDSLVKVEELVK 1430
            |.|.||.|.          ..:....:.::||.||          .....|.:|||        .
  Rat  1035 QRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGGTPGQAPGALPGPGPVKDS--------P 1091

  Fly  1431 VLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQL-------EQANGE- 1487
            :|.:::.|....:...|..|..|:...:|:          |||....|...       |...|.
  Rat  1092 LLLQQISAMRLHISQLQHENSILRGAQMKA----------SLAALPPLHVAKFSLPPHEGPGGNL 1146

  Fly  1488 LKEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLK 1552
            |..||.:|.:.|.|   ||::.:|        |..:.|    ..:.....:..:::|.||::|||
  Rat  1147 LSGALYRKTSQLLE---KLNQLST--------HTHVVD----ITRSSPAAKSPSAQLMEQVAQLK 1196

  Fly  1553 QANEELQK 1560
            ..::.::|
  Rat  1197 SLSDTIEK 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	3/9 (33%)
		CAP_GLY	125..189	CDD:396049	31/64 (48%)
		CAP_GLY	239..306	CDD:396049	8/66 (12%)
		SMC_prok_B	<546..912	CDD:274008	78/373 (21%)
		Smc	734..1591	CDD:224117	183/936 (20%)
		SHE3	1502..1702	CDD:293683	12/59 (20%)
		CLIP1_ZNF	1773..1789	CDD:406934
Dctn1	NP_077044.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/13 (31%)
		CAP_GLY	29..94	CDD:396049	31/64 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..223		46/320 (14%)
		Herpes_BLLF1	<101..>214	CDD:282904	43/294 (15%)
		SMC_prok_B	220..>540	CDD:274008	87/407 (21%)
		Dynactin	527..805	CDD:403600	56/311 (18%)
		Interaction with HPS6. /evidence=ECO:0000250\|UniProtKB:O08788	911..1281		68/345 (20%)
		SMC_prok_A	<924..>1037	CDD:274009	23/130 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1090		6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810