DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and NBPF15

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_001372377.1	Gene:	NBPF15 / 284565	HGNCID:	28791	Length:	698	Species:	Homo sapiens

Alignment Length:	624	Identity:	140/624 - (22%)
Similarity:	249/624 - (39%)	Gaps:	153/624 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1246 LQAEKSETNHIFELFEMEADMNSERLIEKVTGIKEELKETHLQ--LDERQK--KFEELEEKLKQA 1306
            |.:||:|.| |.|:.|......:|:. ::...:||:...|.|.  |..|||  |:||.::.:|
Human     8 LSSEKAEMN-ILEINEKLRPQLAEKK-QQFRNLKEKCFLTQLAGFLANRQKKYKYEECKDLIK-- 68

  Fly  1307 QQSEQKLQQESQTSKEKLTEIQQSLQELQDSV----KQKEELVQNLEEKVRESSSIIEAQNTKLN 1367
                ..|:.|.|..:|||.|..:..:||:...    .|:.||.| |.||:||......:.|..|.
Human    69 ----FMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQ-LREKLREGRDASRSLNEHLQ 128

  Fly  1368 ESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVL 1432
            ......|...|..::.|:||.|..:..:.|.:   |||.|       |.:..|..|:||     :
Human   129 ALLTPDEPDKSQGQDLQEQLAEGCRLTQHLVQ---KLSPE-------NDNDDDEDVQVE-----V 178

  Fly  1433 EEKLQAATSQLDAQQATNKE-----LQELLVKSQENEG----NLQGESLAVTEKLQQLE------ 1482
            .||:|.:::..:.|:|..||     |:|..:....:.|    |...:...:|.:..:::
Human   179 AEKVQKSSAPREMQKAEEKEVPEDSLEECAITCSNSHGPYDSNQPHKKTKITFEEDKVDSTLIGS 243

  Fly  1483 QANGELKEALC-----------QKENGLKELQGKLDES------NTVLESQKK-----SHNEIQD 1525
            .::.|.::|:.           ::|.|....:| :||:      .|:..::.:     :|..:|:
Human   244 SSHVEWEDAVHIIPENESDDEEEEEKGPVSPRG-MDEAGNHHSQQTIARTKNQIPHVLTHRNLQE 307

  Fly  1526 KLEQAQQKE--------------------------RTLQEETSKLAEQL-----SQLKQANEELQ 1559
            ..|:...:|                          .:|:|:...:|..:     .|:|:.::|..
Human   308 SEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEAT 372

  Fly  1560 KSLQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTA 1624
            .....::||.||         |.:.:.|.:|...|..|..||            |..:....::|
Human   373 GPRLSRELLDEK---------EPEVLQDSLDRCYSTPSGCLE------------LTDSCQPYRSA 416

  Fly  1625 Y--LETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKG--DEVESLDIETSLAKINFLNSII 1685
            :  ||.:.:...::..|:||.:||   :...:.:..|..:.  ||.|...::.||.:.....|..
Human   417 FYVLEQQRVGLAIDMDEIEKYQEV---EEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSDY 478

  Fly  1686 ADMQQKNDALKAKVQTLE------TLPMDFTKPHAFDALTKRKPAPRLFCDICDEFDQHDTEDCP 1744
            .::........:.|.:||      .|.:|..|....:...:..|.|||..::.:.     .|...
Human   479 LELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEV-----VEPEV 538

  Fly  1745 IQGSEDQDYSTPSSESNNNEKERKLPAPRKYCDSCEVFG 1783
            :|.|.|:.||||||         .|..|    |||:.:|
Human   539 LQDSLDRCYSTPSS---------CLEQP----DSCQPYG 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049
		SMC_prok_B	<546..912	CDD:274008
		Smc	734..1591	CDD:224117	93/420 (22%)
		SHE3	1502..1702	CDD:293683	42/245 (17%)
		CLIP1_ZNF	1773..1789	CDD:406934	4/11 (36%)
NBPF15	NP_001372377.1	DUF1220	179..240	CDD:399619	12/60 (20%)
		DUF1220	<316..353	CDD:399619	3/36 (8%)
		DUF1220	366..429	CDD:399619	16/83 (19%)
		DUF1220	439..504	CDD:399619	12/67 (18%)
		DUF1220	514..579	CDD:399619	20/69 (29%)
		DUF1220	610..672	CDD:399619
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000