DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and Clip2

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_034120.2	Gene:	Clip2 / 269713	MGIID:	1313136	Length:	1047	Species:	Mus musculus

Alignment Length:	1331	Identity:	332/1331 - (24%)
Similarity:	564/1331 - (42%)	Gaps:	379/1331 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGT--GIPQPSKMKAPSSFGSTGSVSKIG 72
            |......||| ..|..|:.:|.:         ..:|||:  |.|...:...|||.|:..:||:
Mouse    11 GRGGKHSSPV-GRPSVGSASSSV---------VASTSGSKEGSPLHKQASGPSSSGAATTVSE-- 63

  Fly    73 RPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPG 137
                     |.||...|.      .||.|.                   .|::|:|||:.|.:||
Mouse    64 ---------KPGPKAAEV------GDDFLG-------------------DFVVGERVWVNGVKPG 94

  Fly   138 QIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRLTRLTTYPLA---GAQT 199
            .:.::|:|.||.|:|||||||:|.|||||.|.|.|||:|...:|||:|.::||..|.|   |:.|
Mouse    95 VVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDT 159

  Fly   200 PT--SPLAKSSPDRSRTVSPTAS-----IRSSMLRSP-GIGGKNG---------------MAVGD 241
            .:  |..|::....|.|.:|..:     :|.|:|.|. ..|.::|               :.:||
Mouse   160 HSVESLTAQNLSLHSGTATPPLTGRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGDKDLHLGD 224

  Fly   242 RVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKV 306
            ||:|.   |::.|::||:|||.||.|.|||||||||.|||||.|...|||:|.||:|:|.||.||
Mouse   225 RVLVG---GTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKV 286

  Fly   307 ------SLSPS-SKKTR-----LSRTGSRESLTSIGTMNSIATTATSR-MRMNAQQRKSSTPVKP 358
                  |.||: :|||:     :|......|.:||.:::|:|::...| .|.......||...:.
Mouse   287 IRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARK 351

  Fly   359 ILATPKSQFSMQDLLREKQQHVEKLMVERDLDRED---AQNQALQLQKNINEVIIFTDTMYAPLP 420
            |..|.    ::|:.|:|||||:|:|:.||||:|.:   |.:...:::|.|
Mouse   352 ISGTT----ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEI--------------- 397

  Fly   421 YADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQ 485
                         :.:|...:|::
Mouse   398 -------------ALLKAQHEQYV----------------------------------------- 408

  Fly   486 QQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNA 550
              ....:|.|:|: ..|....|:|        |:|.:.|:.||:|.|:||..::|......:|..
Mouse   409 --AEAEEKLQRAR-LLVENVRKEK--------VDLSNQLEEERRKVEDLQFRVEEESITKGDLET 462

  Fly   551 QSQVYKEKIHDLE-SKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVES--- 611
            |:|:...:|.:|| |.:.:...|...|:.:....|.:  .|.:..:.:|:|::::::.|:|.
Mouse   463 QTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTT--VAEKSRVLQLEEELSLRRGEIEELQH 525

  Fly   612 -------RIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEAL--EKFSLSECGIENLRRELEL 667
                   ..|:..|..:.||     |.|::.:...| ..:|..|  :|:   |..::..:.|::.
Mouse   526 CLLQSGPPPADHPEAAETLR-----LRERLLSASKE-HQRDSTLLQDKY---EHMLKTYQTEVDK 581

  Fly   668 LKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECE-ILQTEVRM 731
            |:..|||.|||. |:...|:.:.:.|.:.|   :.|.|:..|||.|:.....::.: .|.:....
Mouse   582 LRAANEKYAQEV-ADLKAKVQQATTENMGL---MDNWKSKLDSLASDHQKSLEDLKATLNSGPGA 642

  Fly   732 RDEQIRELNQQLDEVTTQLNVQKADSSALDD----MLRLQKEGTEEKSTLLEKTEKELVQSKEQA 792
            :.::|.||...::.:..:..::..:..|..|    |...:|||..:|   |::.::||      |
Mouse   643 QQKEIGELKALVEGIKMEHQLELGNLQAKHDLETAMHGKEKEGLRQK---LQEVQEEL------A 698

  Fly   793 AKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSE 857
            ....:.:||||:|       |.|.:|                            ||::.|.:..:
Mouse   699 GLQQHWREQLEEQ-------ASQHRL----------------------------ELQEAQDQCRD 728

  Fly   858 SEVHLQEIKAQNTQKDFELVESGESLKKLQQQL---EQKTLGHEKLQAALEELKKEKETIIKEKE 919
            :::..||::.    .|.|.....::::.|::|:   |:|.|.:|.||.|           ..:..
Mouse   729 AQLRAQELEG----LDVEYRGQAQAIEFLKEQISLAEKKMLDYEMLQRA-----------EAQSR 778

  Fly   920 QELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKS 984
            ||.::|:.|...:|:.|            |||.|      ..:..|..:.:....:||| ..:|.
Mouse   779 QEAERLREKLLVAENRL------------QAAES------LCSAQHSHVIESSDLSEET-IRMKE 824

  Fly   985 TQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAAN 1049
            |...|:.|          |.:..|:...|..|:..|:::|...:....|....::|..|:.....
Mouse   825 TVEGLQDK----------LNKRDKEVTALTSQMDMLRAQVSALENKCKSGEKKIDSLLKEKRRLE 879

  Fly  1050 AALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTS 1114
            |.||.|::                           :...:|...:|.
Mouse   880 AELEAVSR---------------------------KTHDASGQLVHI------------------ 899

  Fly  1115 KADAWSQEMLQKEKELQELRQQLQDSQD---------SQTKLKAEGERKEKSFEESIKNLQEEVT 1170
                 |||:|:||:.|.|||..|.::..         |:...|||...||:..::.|:.|:|::|
Mouse   900 -----SQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLT 959

  Fly  1171 KAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKIA-----DLKTLVEAIQVAN- 1229
            ....|. .||...:.::.|.....|:  .:||| :.:::|||.:.|     .::.||||::..:
Mouse   960 GLDKEK-SLSEQRRYSLIDPASPPEL--LKLQH-QLVSTEDALRDALNQAQQVERLVEALRGCSD 1020

  Fly  1230 -----ANISATNAELSTVLEVLQAEKSETNH 1255
                 :|..:.|.    :.:..:|.|.|..|
Mouse  1021 RTQTISNSGSANG----IHQPDKAHKQEDKH 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	25/109 (23%)
		CAP_GLY	125..189	CDD:396049	35/63 (56%)
		CAP_GLY	239..306	CDD:396049	40/66 (61%)
		SMC_prok_B	<546..912	CDD:274008	83/386 (22%)
		Smc	734..1591	CDD:224117	114/549 (21%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
Clip2	NP_034120.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		21/80 (26%)
		CAP_GLY	83..146	CDD:279625	35/62 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..164		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..216		2/19 (11%)
		CAP_GLY	223..286	CDD:279625	40/65 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..340		7/25 (28%)
		DUF4349	<380..485	CDD:305044	29/184 (16%)
		mycoplas_twoTM	572..>658	CDD:275320	22/89 (25%)
		TTKRSYEDQ	<683..871	CDD:287216	57/275 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1022..1047		5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2817
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2066
Isobase	1	0.950	-	0	Normalized mean entropy	S5390
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D463666at33208
OrthoFinder	1	1.000	-	-		FOG0002895
OrthoInspector	1	1.000	-	-		otm42428
orthoMCL	1	0.900	-	-		OOG6_104816
Panther	1	1.100	-	-	O	PTHR18916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	1	1.000	-	-		X2251
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810