Protein Alignment CLIP-190 and Utrn

DIOPT Version :9

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: XP_006512769.1
• Gene: Utrn / 22288
• MGIID: 104631
• Length: 3435
• Species: Mus musculus
• Alignment Length: 1777
• Identity: 354/1777 - (19%)
• Similarity: 652/1777 - (36%)
• Gaps: 549/1777 - (30%)

  Fly   320 TGSRESLTSIGTMN-------SIATTATSRMRMNAQQRKSS--------TPVKPILATPKSQFSM 369
            |...|:|..:.|.|       |::....:.::.:.:.::.:        ..|..:|:.||:...|
Mouse   551 TEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLSNPKASKKM 615

  Fly   370 QDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSKKS 434
            .....|..|..:.| |:|   .||:.||..|....:.         .:.:|..|........::.
Mouse   616 NSDSEELTQRWDSL-VQR---LEDSSNQVTQAVAKLG---------MSQIPQKDLLETVHVREQG 667

  Fly   435 RVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQAKP 499
            .||.|:|:....|......|......:....|.:.........::..:|..:... ::|.|:...
Mouse   668 MVKKPKQELPPPPPPKKRQIHVDVEAKKKFDAISTELLNWILKSKTAIQNTEMKE-YKKSQETSG 731

  Fly   500 KKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEKIHDLES 564
            .      ||||           ..|:.|:|  |.|...        ||||...|..:|::
Mouse   732 M------KKKL-----------KGLEKEQK--ENLPRL--------DELNQTGQTLREQM----- 764

  Fly   565 KITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKY 629
                                 ..:|...||:..:.|:::::.|.:..:: |.|..:.:|:|::..
Mouse   765 ---------------------GKEGLSTEEVNDVLERVSLEWKMISQQL-EDLGRKIQLQEDINA 807

  Fly   630 LNEQIATLQSELVSKDEALEKFSLSE--------------------------------------- 655
            ..:|:..::..:..|:|.|....:||
Mouse   808 YFKQLDAIEETIKEKEEWLRGTPISESPRQPLPGLKDSCQRELTDLLGLHPRIETLCASCSALKS 872

  Fly   656 --C-------GIENLRRELELLKE---------ENEKQAQEAQAEF------------TRKLAEK 690
              |       |.::||...:.:::         |||.::|...|..            :.|.|:.
Mouse   873 QPCVPGFVQQGFDDLRHHYQAVRKALEEYQQQLENELKSQPGPAYLDTLNTLKKMLSESEKAAQA 937

  Fly   691 SVEVLR----LSSELQNLKATSDSLESER--------VNKTDECEILQTEVRMRDEQIRELNQQ- 742
            |:..|.    :...||..||..::||:::        ..||.|..:|....:|..::..::..:
Mouse   938 SLNALNDPIAVEQALQEKKALDETLENQKHTLHKLSEETKTLEKNMLPDVGKMYKQEFDDVQGRW 1002

  Fly   743 -------------LDEVTTQLNVQKADS-------SALDDMLRLQKEGTEEKSTLLEKTEKELVQ 787
                         |:|:|.:|...:|||       |.:.|.|..::....:.:.|         |
Mouse  1003 NKVKTKVSRDLHLLEEITPRLRDFEADSEVIEKWVSGIKDFLMKEQAAQGDAAAL---------Q 1058

  Fly   788 SK-EQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAIN----------QIQLEKESIEQQL 841
            |: :|.|...|:.|.:|   |.||.:.|.|..::......:.          |.||||.|  :::
Mouse  1059 SQLDQCATFANEIETIE---SSLKNMREVETSLQRCPVTGVKTWVQARLVDYQSQLEKFS--KEI 1118

  Fly   842 ALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKK-----LQQQLEQKTLGHEKLQ 901
            |::::.|.|.|:            ||.|.:||  |.|..|.:.:     |::..|.|:  .|:|:
Mouse  1119 AIQKSRLSDSQE------------KALNLKKD--LAEMQEWMAQAEEDYLERDFEYKS--PEELE 1167

  Fly   902 AALEELKKEKETIIKEKEQELQQL---------------QSKSAESESALKVVQVQLEQLQQQAA 951
            :|:||:|:.||.:: :||..::.|               |..::|....|:..|:...:::.:..
Mouse  1168 SAVEEMKRAKEEVL-QKEVRVKILKDSIKLVAAKVPSGGQELTSEFNEVLESYQLLCNRIRGKCH 1231

  Fly   952 ASGEEGSKTVAKLH----------------DEISQLKSQAEETQSELKSTQSNL----------- 989
            ...|..|..|..||                .....|..:||.....|:|.:|.|
Mouse  1232 TLEEVWSCWVELLHYLDLETTWLNTLEERVRSTEALPERAEAVHEALESLESVLRHPADNRTQIR 1296

  Fly   990 -------------EAKSKQLEAANGSLEE-----EAK------------KSGHLLEQITKLKSEV 1024
                         :..|::|||.|...||     |:|            ::.|:|:   .||..:
Mouse  1297 ELGQTLIDGGILDDIISEKLEAFNSRYEELSHLAESKQISLEKQLQVLRETDHMLQ---VLKESL 1358

  Fly  1025 GETQAALSSCHTD-VESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAER 1088
            ||....|::..|| :::.....||     :|:..|.:.......:|:..|:....| ..|.:|.|
Mouse  1359 GELDKQLTTYLTDRIDAFQLPQEA-----QKIQAEISAHELTLEELRKNVRSQPPT-SPEGRATR 1417

  Fly  1089 SSS--SALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQ--DSQD------- 1142
            ..|  ..|..||.:.|.:.     :|..|...:.|.||..::.|:.::.:|.  |.:|
Mouse  1418 GGSQMDMLQRKLREVSTKF-----QLFQKPANFEQRMLDCKRVLEGVKAELHVLDVRDVDPDVIQ 1477

  Fly  1143 -------------SQTKLKAEGERK------EKSFEESIKNLQEEVTKAKT-------------E 1175
                         |:.||:.|...|      :|...::.|::.|::|..|.             :
Mouse  1478 AHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKSMDEQLTSLKVLYNDLGAQVTEGKQ 1542

  Fly  1176 NLELSTGTQTTIKD----LQERLEITNAELQHKEKMASEDAQKIADLKTLV----------EAIQ 1226
            :||.::.....:|.    |.|.|..|.|||  .:|..||..  |.||.|.:          |..:
Mouse  1543 DLERASQLSRKMKKEAAVLSEWLSATEAEL--VQKSTSEGV--IGDLDTEISWAKSILKDLEKRK 1603

  Fly  1227 VANANISATNAEL-------STVLE----VLQAEKSET------------NH-----IFE----- 1258
            |....|:.::|.|       .:|||    ||.|..|..            ||     :|:
Mouse  1604 VDLNGITESSAALQHLVLGSESVLEENLCVLNAGWSRVRTWTEDWCNTLLNHQNQLELFDGHVAH 1668

  Fly  1259 ----LFEMEADMNSERLIEKVTGIKEE--LKETHLQLDERQKKFEELEEK---LKQAQQSEQKLQ 1314
                |::.||.::.   |||....|:|  :|....:||:...:.|.:.|:   |..|:.|..:
Mouse  1669 ISTWLYQAEALLDE---IEKKPASKQEEIVKRLLSELDDASLQVENVREQAIILVNARGSASR-- 1728

  Fly  1315 QESQTSKEKLTEIQQSLQELQDSVKQKEELV-------------------------QNLEEKVRE 1354
               :..:.||.|:.::.:::...:|....|:                         :|||:.:..
Mouse  1729 ---ELVEPKLAELSRNFEKVSQHIKSARMLIGQDPSSYQGLDPAGTVQAAESFSDLENLEQDIEN 1790

  Fly  1355 SSSIIEA-----QNTKLNESNVQLENKTSCLKETQDQLLESQKKEK------------------- 1395
            ...::|.     .:.|::|...|:|......:....:.:|..||||
Mouse  1791 MLKVVEKHLDPNNDEKMDEEQAQIEEVLQRGEHLLHEPMEDSKKEKIRLQLLLLHTRYNKIKTIP 1855

  Fly  1396 -QLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEE-KLQAATSQLDAQQATNKELQELLV 1458
             |.::.....||.......|     |.||::.:::..|:: :|.....:|:.....:...||..:
Mouse  1856 IQQRKTIPVSSGITSSALPA-----DYLVEINKILLTLDDIELSLNMPELNTTVYKDFSFQEDSL 1915

  Fly  1459 KSQENEGNLQGESLAVTEKLQQ--LEQANGELKEALCQKENGLKELQGKLDESNTVLESQKKSHN 1521
            ||.:.:.:..||.:||..:.|.  :.:|:|  .||: |..:.|.:|..|.|..|.|...::.|
Mouse  1916 KSIKGQLDRLGEQIAVVHEKQPDVIVEASG--PEAI-QIRDMLAQLNAKWDRVNRVYSDRRGS-- 1975

  Fly  1522 EIQDKLEQAQQKERTLQEETSKLAEQLSQLK---------QANEELQKSLQQKQLLLEKGNEFDT 1577
                 ..:|.::.|....:...|.:.||:.:         ..:.:|:|:..| ||.||:|
Mouse  1976 -----FARAVEEWRQFHHDLDDLTQWLSEAEDLLVDTCAPDGSLDLEKARAQ-QLELEEG----- 2029

  Fly  1578 QLAEYQ----KVIDEMDDAASVKSALLEQLQ-NRVAELETALRQANDAQKTAYLETKELRRQLES 1637
             |:.:|    ||..:.:|       |:::|: :..:.|:..|...|....|...|.:.|:.:|:.
Mouse  2030 -LSSHQPSLIKVNRKGED-------LVQRLRPSEASFLKEKLAGFNQRWSTLVAEVEALQPRLKG 2086

  Fly  1638 LELEKSREVLSLKAQMN----------GASSRSGKGDEVESLDIETSLAK--------INFLNSI 1684
                :|::||..|.:::          .|..:....|..||....|.||:        |.:||..
Mouse  2087 ----ESQQVLGYKRRLDEVTCWLTKVESAVQKRSTPDPEESPQELTDLAQETEVQAENIKWLNRA 2147

  Fly  1685 IADM-QQKNDALKAKVQTLETL 1705
            ..:| ..||.:|:.:.:..|:|
Mouse  2148 ELEMLSDKNLSLREREKLSESL 2169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049
		SMC_prok_B	<546..912	CDD:274008	95/483 (20%)
		Smc	734..1591	CDD:224117	237/1131 (21%)
		SHE3	1502..1702	CDD:293683	51/232 (22%)
		CLIP1_ZNF	1773..1789	CDD:406934
Utrn	XP_006512769.1	SAC6	37..>274	CDD:227401
		SPEC	315..531	CDD:238103
		SPEC	430..635	CDD:238103	16/87 (18%)
		SPEC	<744..909	CDD:351773	30/201 (15%)
		PRK03918	883..1502	CDD:235175	140/663 (21%)
		CCDC158	1312..>1838	CDD:318193	118/551 (21%)
		SPEC	1982..2184	CDD:238103	46/206 (22%)
		SPEC	2233..2445	CDD:238103
		SPEC	2453..2693	CDD:238103
		SPEC	2695..>2811	CDD:238103
		WW	2820..2848	CDD:238122
		EFh_UTRO	2885..3046	CDD:320005
		EF-hand-like motif	2885..2923	CDD:320005
		EF-hand-like motif	2931..2965	CDD:320005
		EF-hand-like motif	2971..3007	CDD:320005
		EF-hand-like motif	3020..3046	CDD:320005
		ZZ_dystrophin	3071..3119	CDD:239074

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000