DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and NBPF11

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_001095133.3	Gene:	NBPF11 / 200030	HGNCID:	31993	Length:	865	Species:	Homo sapiens

Alignment Length:	1095	Identity:	217/1095 - (19%)
Similarity:	393/1095 - (35%)	Gaps:	297/1095 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 IAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNER 528
            :.:|...::..|..|...:.::.:|.|.:.:||.:..      |::.|     :.:|...|.|.:
Human     2 VVSAGPWSSEKAEMNILEINEKLRPQLAENKQQFRNL------KERCF-----LTQLAGFLANRQ 55

  Fly   529 KKTEELQCS-------IDEAQFCGDELNAQ------SQVYKEKIHDLESKITKL----------- 569
            ||.:..:|.       .:|.||..::|..|      .:.||..:|..|.::|:|
Human    56 KKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDAS 120

  Fly   570 VSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYLNEQI 634
            .|....||::|.||.|                    .|.....:.|||.|..||.::
Human   121 RSLNEHLQALLTPDEP--------------------DKSQGQDLQEQLAEGCRLAQH-------- 157

  Fly   635 ATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSS 699
                  ||.|                      |..|.:|.:.::.|.|...|:.|.|..  |...
Human   158 ------LVQK----------------------LSPENDEDEDEDVQVEEDEKVLESSAP--REVQ 192

  Fly   700 ELQNLKATSDSLESERV---NKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADS-SAL 760
            :.:..|...||||...:   |....|:.:|....::      :..:.|:|.:.|.|.:..| ...
Human   193 KAEESKVPEDSLEECAITCSNSHGPCDSIQPHKNIK------ITFEEDKVNSSLVVDRESSHDGC 251

  Fly   761 DDMLR-LQKEGTEEKSTLL-----------EKTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLA 813
            .|.|. |...|....:|.:           ||.|..:::..|:..                .|||
Human   252 QDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLC----------------PQLA 300

  Fly   814 EQEKLVREMTENA-INQIQ--LEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFE 875
            |:::..|.:.|.. :.|:.  |.|    ||...|..|.:|..|....:|...:|
Human   301 EKKQQFRSLKEKCFVTQVACFLAK----QQNKYKYEECKDLIKSMLRNERQFKE----------- 350

  Fly   876 LVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQ 940
                    :||.:||:|           .|||::.| .::..:|:||.||:.|..|...|.:.:.
Human   351 --------EKLAEQLKQ-----------AEELRQYK-VLVHSQERELTQLREKLREGRDASRSLN 395

  Fly   941 VQLEQLQQQAAASGEEGSKTVAK-LHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLE 1004
            ..|     ||..:.:|..|:..: |.:::::....|:....:|.....|.:.:..|:|.|
Human   396 EHL-----QALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVA----- 450

  Fly  1005 EEAKKSGHLLEQITKLKSEVGE---TQAAL--SSCHTDVESKTKQLEAANAALEKVNKEYAESRA 1064
            |:.:||....|.....:.||.|   .:.|:  |:.|...:|        |....|....:.|.:.
Human   451 EKVQKSSSPREMQKAEEKEVPEDSLEECAITCSNSHGPYDS--------NQPHRKTKITFEEDKV 507

  Fly  1065 EASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKE 1129
            :::       .|..:.|.|.:      .|:|......||:     :|...|.....:.:.:.|:|
Human   508 DST-------LIGSSSHVEWE------DAVHIIPENESDD-----EEEEEKGPVSPRNLQESEEE 554

  Fly  1130 LQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERL 1194
              |:.|:..|...|...:..|.....:|:..:..:|:|:..     .:.:..|.....:..:|..
Human   555 --EVPQESWDEGYSTLSIPPERLASYQSYSSTFHSLEEQQV-----CMAVDIGRHRWDQVKKEDQ 612

  Fly  1195 EITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFEL 1259
            |.|...|. :|.:..::.:.:.|  :|.......:..:..|::        .|..:|    .|.:
Human   613 EATGPRLS-RELLDEKEPEVLQD--SLDRCYSTPSVYLGLTDS--------CQPYRS----AFYV 662

  Fly  1260 FEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQES--QTSKE 1322
            .|.:.           .|:..::.|.        :|::|:||.           |..|  :.|:|
Human   663 LEQQR-----------IGLAVDMDEI--------EKYQEVEED-----------QDPSCPRLSRE 697

  Fly  1323 KLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQN--TKLNESNVQLENKTSCLKETQD 1385
            .|.|            |:.|.|..:|:......|..:|..:  .....:...||.:...|....|
Human   698 LLAE------------KEPEVLQDSLDRCYSTPSGYLELPDLGQPYRSAVYSLEEQYLGLALDVD 750

  Fly  1386 QLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQATN 1450
            ::.:.|::|:.......:||.||.:|.|.. .::|||..::.|..||.....|:.:::.......
Human   751 RIKKDQEEEEDQGPPCPRLSRELLEVVEPE-VLQDSLDVIQLLPVVLNSLTPASPTEVPFMHWRK 814

  Fly  1451 KELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGK 1505
            ..|..||                ..|||::..:...|.:|...:||.| :|.:||
Human   815 NMLAFLL----------------TWEKLKRRGRGRKEGEEDQRRKEEG-EEKKGK 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049
		SMC_prok_B	<546..912	CDD:274008	81/401 (20%)
		Smc	734..1591	CDD:224117	157/798 (20%)
		SHE3	1502..1702	CDD:293683	2/4 (50%)
		CLIP1_ZNF	1773..1789	CDD:406934
NBPF11	NP_001095133.3	SbcC	<11..>401	CDD:223496	109/520 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..200		11/62 (18%)
		DUF1220	181..240	CDD:399619	14/66 (21%)
		DUF1220	450..511	CDD:399619	15/80 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..475		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..567		11/59 (19%)
		DUF1220	540..596	CDD:399619	11/62 (18%)
		DUF1220	609..671	CDD:399619	13/87 (15%)
		DUF1220	682..747	CDD:399619	18/87 (21%)
		DUF1220	757..821	CDD:399619	15/64 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	829..865		8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000