DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and CCDC27

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_016855891.1	Gene:	CCDC27 / 148870	HGNCID:	26546	Length:	747	Species:	Homo sapiens

Alignment Length:	691	Identity:	146/691 - (21%)
Similarity:	252/691 - (36%)	Gaps:	189/691 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 SLSECG----------IENL------RRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSE 700
            |:|.||          |:|.      .::|.|.:..::.........|::.:.|  .:.||...:
Human   143 SMSHCGSPTEADLSGEIDNSSETWRGTQDLFLARRGSDTNVDGYLLPFSKSICE--FDYLRKRRK 205

  Fly   701 LQNLK-ATSDSLESER------------VNKTDEC-EILQTEVRMRDEQIRELNQQLDEVTTQLN 751
            .|.|. .||.|:.|:.            :::.|.| ..|:.:|:.:||:|..|.::.:.:..||.
Human   206 SQTLSPVTSSSVASQSCLRKRMPWYLSVIHEKDHCLSELEIQVQKKDEEILLLQEEREALKMQLK 270

  Fly   752 V-----------------QKADSSALDDMLRLQKEGTEEKSTLLEKTEKELV---QSKEQAAKTL 796
            .                 |.:|:|.....|.|.|        ...:.|:||.   |.:|::|...
Human   271 CLLKGKGQETSMSPGRREQLSDASLKLGRLSLLK--------AFSRHEEELQHWWQMQEESAAPE 327

  Fly   797 NDKEQLEKQISDLKQLAEQEKLVREM-------TENAINQI-QLEKESIEQQLALKQNELEDFQK 853
            ..||      .||....|.|.|..|.       ....::|: .:.:|..|::...:.:..||.::
Human   328 RGKE------PDLGGGEEDEGLEGEPDGVEDTGAWGGVSQMGSVHEEGSEEEEEEEGDRDEDSEE 386

  Fly   854 KQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEK 918
            ::...|..:...:|.:..:.||                      |:|.|.|||.    |.:|.:.
Human   387 RELPEEEEIPRRRASSLAESFE----------------------EELLAQLEEY----EQVILDF 425

  Fly   919 EQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELK 983
            :..|:..:::.:               |....|::|..|...::.     |:.:|...:|...|.
Human   426 QFNLEATRTRYS---------------LATGRASAGGTGLWPLSG-----SRPRSWDAQTLPALV 470

  Fly   984 STQSNLEAKSKQLEAANGSLEEEAKK---SGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQL 1045
            |     |.:..|:.||:..|.|.::.   .|.||..:|   :........|..|...:.|..:|:
Human   471 S-----ELEQGQVSAASPRLAEPSQLPQWPGPLLLSLT---APACSCSPPLPLCPGVIASLQQQV 527

  Fly  1046 EAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHK 1110
            :.....|.|:|.|                  .:||..||:..|....|:..|.|..
Human   528 DFQETQLRKINTE------------------NETLQKELRERRQQLQAMTDKFSNL--------- 565

  Fly  1111 ELTSKADAWSQEMLQK-EKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKT 1174
                :.|...|||:.. ||:.|.||||:           :|.|||....:..|..|..:|::.:
Human   566 ----REDKKHQEMMGLIEKDNQLLRQQV-----------SELERKLTKRDCVISELDTKVSQLQ- 614

  Fly  1175 ENLELSTGTQTTIKDLQERLEITNAELQHKE---KMASEDAQKIADLKTLVEAIQVANANISATN 1236
            |.:||........|.|||.|:.....:|..|   ::|.|.:|  :.|:.|...|..|..:||.|.
Human   615 EQVELDQNHLQRWKQLQEDLQSKKEMIQQAEQHTRVALESSQ--SRLERLRNKIIQATFSISGTK 677

  Fly  1237 AELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTG 1277
            :         .|.:...|.|.|..:..:....||:..:..|
Human   678 S---------LANEISDNDILEALQQASLEEEERVASRAAG 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049
		SMC_prok_B	<546..912	CDD:274008	63/317 (20%)
		Smc	734..1591	CDD:224117	123/579 (21%)
		SHE3	1502..1702	CDD:293683
		CLIP1_ZNF	1773..1789	CDD:406934
CCDC27	XP_016855891.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000