DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and Dctn1

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_031861.2	Gene:	Dctn1 / 13191	MGIID:	107745	Length:	1281	Species:	Mus musculus

Alignment Length:	1591	Identity:	312/1591 - (19%)
Similarity:	574/1591 - (36%)	Gaps:	531/1591 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 SAYTDNSSAVLT-ANTEQFIIGQRV-WLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCV 168
            |:.|.:.|.:.| |:.....:|.|| .:|....|.:|::|.|.||.|:|.||:|||..|||||.|
Mouse     9 SSRTPSGSRMSTEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTV 73

  Fly   169 SGKRYFQCEPKRGIFSRLTRLTTYPLAGAQTPTSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGG 233
            .|::||.|:...|||.|.:::..:. .||.| |||   .:||.|         .|.:|:..|
Mouse    74 QGRKYFTCDEGHGIFVRQSQIQVFE-DGADT-TSP---ETPDSS---------ASKVLKREG--- 121

  Fly   234 KNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYG 298
                         :...::...||.|                                  |||.
Mouse   122 -------------ADAAAKTSKLRGL----------------------------------KPKK- 138

  Fly   299 VFVPIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATP 363
              .|.|:.:.:...|.||.:.||.....:|:|...|.:....|       ..:.|||.:..||.|
Mouse   139 --APTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGELS-------SSEPSTPAQTPLAAP 194

  Fly   364 KSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPY 428
                                                         ||
Mouse   195 ---------------------------------------------II------------------ 196

  Fly   429 RPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQK 493
                                             ||.|..:..||       .||...      .|
Mouse   197 ---------------------------------PTPALTSPGAA-------PPLPSP------SK 215

  Fly   494 QQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYKEK 558
            :::.               |:|::.:||..|:..|.|..|.:..:.|.:        :.::..|:
Mouse   216 EEEG---------------LRAQVRDLEEKLETLRLKRSEDKAKLKELE--------KHKIQLEQ 257

  Fly   559 IHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRL 623
            :.:.:||                         :||:.|.||.::    ||......|.||.::|.
Mouse   258 VQEWKSK-------------------------MQEQQADLQRRL----KEARKEAKEALEAKERY 293

  Fly   624 RENVKYLNE--QIATLQSELV-SKDEAL--EKFSLSECGIENLRRELELLKEENEKQAQEAQAEF 683
            .|.:....:  ::|||..|:. .:.|:|  |..:|.| .::.|..:||:||.|.|::..:..|.
Mouse   294 MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE-RVDELTTDLEILKAEIEEKGSDGAAS- 356

  Fly   684 TRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTT 748
            :.:|.:...:..||...|..::..|.|.:.|.|.       ||..:..:::::..:.||.:
Mouse   357 SYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK-------LQKLMEKKNQELEVVRQQRE---- 410

  Fly   749 QLNVQKADSSALDDMLRLQKEGTEEKSTLLE-KTEKELVQSKEQAAKTLNDKE-QLEKQISDLKQ 811
                            |||:|.::.:||:.| |.:.:.....|:..:.|.|:. .||:::.:|::
Mouse   411 ----------------RLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRE 459

  Fly   812 LAEQEKLVREMTENAINQIQLEKESIEQQLALK-QNELEDFQKKQSESEVHLQEIKAQNTQKDFE 875
            .....:.:.||.:      :|::.:.|.:|.|: |.::...:.::::..|.    .||.|..|::
Mouse   460 TVGDLEAMNEMND------ELQENARETELELREQLDMAGARVREAQKRVE----AAQETVADYQ 514

  Fly   876 LVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQ---ELQQLQSKSAESESALK 937
                 :::||.:|     ...|  ||....||..::|..::.::|   |....:.|.||:::..|
Mouse   515 -----QTIKKYRQ-----LTAH--LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAK 567

  Fly   938 VVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQ-----------------------LKSQAEETQ 979
            .::::|.|:  :.|.:....|...|.:.|...:                       ::.||:|
Mouse   568 AIEMELRQM--EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-- 628

  Fly   980 SELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQ 1044
                  :.:|.....:.....|:..|:...:..|:..::.|::.:...:.|||.|..||..|...
Mouse   629 ------KFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS 687

  Fly  1045 LEAANAA--------LEKVNKEYAESRAEASDLQDKVK--EITDTLHAELQAERSSSS-ALHTKL 1098
            |....:|        :|.::|:..:.......|...:|  :...::|...|.|.|:.. |.|.|.
Mouse   688 LYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKF 752

  Fly  1099 SKFSDEIATGHKELTSKADAWSQEM------LQKEKELQELRQQLQDSQDSQTKLKAEGERKEKS 1157
            ::             |..|....|:      ||..:|..::...|:|.:.|.:..:
Mouse   753 TQ-------------SALDCMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTR--------- 795

  Fly  1158 FEESIKNLQEEV--TKAKTENLELSTGTQT--TIKDLQERL--------EITNAELQHKEKMASE 1210
              :..|.::..:  |.|......|:.|:|.  |:.|.::.|        |:..|..|....:|..
Mouse   796 --QFCKKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 858

  Fly  1211 DAQKIADLKTLV----------------EAIQVANANISATNAELSTVLEVLQAEKSETNHIFEL 1259
            :...:|.|:.|.                |.::.:...:.:|..:|:|.::
Mouse   859 EGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCTILISTMNKLATAMQ--------------- 908

  Fly  1260 FEMEADMNSERLIEK-------VTGIKEELKETH---LQLDERQKKFEELEEKLKQAQQSEQKLQ 1314
               |.:.::||...|       ...::.|:.:..   |:|::|:...:||::.||
Mouse   909 ---EGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK---------- 960

  Fly  1315 QESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSC 1379
                ...|:|:|....|..|:          :.|:...:::...||...|:|:|:...|..|...
Mouse   961 ----IKGEELSEANVRLSLLE----------KKLDSAAKDADERIEKVQTRLDETQTLLRKKEKD 1011

  Fly  1380 LKETQDQL------LESQKKE-KQLQEEAAK--------------------LSGELQQVQEANGD 1417
            .:||.|.|      ||::|.| ||.....:|                    ::||..|...|.|.
Mouse  1012 FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEPQRGGAPGQ 1076

  Fly  1418 ----------IKDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESL 1472
                      :|||        .:|.:::.|....:...|..|..|:...:|:          ||
Mouse  1077 APGALPGPGLVKDS--------PLLLQQISAMRLHISQLQHENSILRGAQMKA----------SL 1123

  Fly  1473 AVTEKLQQL-------EQANGEL-KEALCQKENGLKELQGKLDESNTVLESQKKSHNEIQDKLEQ 1529
            |....|...       |...|.| ..||.:|.:.|.|   ||::.:|        |..:.|
Mouse  1124 AALPPLHVAKLSLPPHEGPGGNLVAGALYRKTSQLLE---KLNQLST--------HTHVVD---- 1173

  Fly  1530 AQQKERTLQEETSKLAEQLSQLKQANEELQK 1560
            ..:.....:..:::|.||::|||..::.::|
Mouse  1174 ITRSSPAAKSPSAQLMEQVAQLKSLSDTIEK 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	4/12 (33%)
		CAP_GLY	125..189	CDD:396049	31/64 (48%)
		CAP_GLY	239..306	CDD:396049	8/66 (12%)
		SMC_prok_B	<546..912	CDD:274008	78/373 (21%)
		Smc	734..1591	CDD:224117	180/956 (19%)
		SHE3	1502..1702	CDD:293683	12/59 (20%)
		CLIP1_ZNF	1773..1789	CDD:406934
Dctn1	NP_031861.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		5/16 (31%)
		CAP_GLY	30..94	CDD:279625	31/63 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..221		45/317 (14%)
		CCDC144C	227..547	CDD:291576	86/407 (21%)
		PCRF	246..>342	CDD:305100	28/133 (21%)
		CASP_C	314..>455	CDD:285395	38/169 (22%)
		Dynactin	525..805	CDD:289240	56/315 (18%)
		Interaction with HPS6. /evidence=ECO:0000269\|PubMed:25189619	911..1281		73/351 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930