Protein Alignment CLIP-190 and CLIP-190

DIOPT Version :10

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: XP_061513552.1
• Gene: CLIP-190 / 1280169
• VectorBaseID: AGAMI1_003611
• Length: 1967
• Species: Anopheles gambiae
• Alignment Length: 2193
• Identity: 673/2193 - (30%)
• Similarity: 1001/2193 - (45%)
• Gaps: 640/2193 - (29%)

  Fly    12 SAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGI-----------------PQPSKMKAP 59
            :||.|:|..|:.|..:|      |::.  |.||..|.|:                 |:||.::.|
Mosquito     6 NAPEPAPPAANGEETST------PVQP--PAPANGGAGVVVVGGGSGIQPPKVRALPKPSGIRPP 62

  Fly    60 ---------SSFGSTGS----------------VSKIGRPCCNHTTPKSGPPPREA-------TS 92
                     :|..||.|                .::|||.|..||.||:||||.|.       :.
Mosquito    63 TANLHGGSTTSLASTSSQLTAAPSTTSSSAGAAATRIGRLCTGHTPPKAGPPPPEPKLPTTFDSK 127

  Fly    93 MSRESDDNLS---------------------------SINSAYTDNSS----------------- 113
            |.|.||.:.:                           |.:|.:..|.|
Mosquito   128 MRRPSDSDYNKTHLPDVDEESETDLAFERPISARSSHSPDSGFRSNRSDRKTSSASTGSDVYWEA 192

  Fly   114 ----------AVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCV 168
                      |||||:|:.||||||||:||.||||||:||:||||.|||||||||||||||||.|
Mosquito   193 TGRRRSSDQGAVLTADTDSFIIGQRVWVGGIRPGQIAYIGETHFAPGEWAGVVLDEPNGKNDGSV 257

  Fly   169 SGKRYFQCEPKRGIFSRLTRLTTYPLA------GAQTPTSPLAKS-----SPDRSRTVSPTASIR 222
            :||||||||.|:|:||||||||..|||      |..|.::||..|     ||.||.|||||.|::
Mosquito   258 AGKRYFQCEAKKGVFSRLTRLTREPLANAGGGGGDSTASTPLDASFRSLTSPARSGTVSPTHSVQ 322

  Fly   223 SSMLRSPGIGGK-NGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVD 286
            |...:||.:.|| ..:.||||||||||||||||:|:::||||||.|.||||:|||.|||||||||
Mosquito   323 SYASKSPAMAGKAASLNVGDRVIVSSGFGSRPGMLKFIGETQFASGTWCGVQLDEASGKNDGTVD 387

  Fly   287 DIRYFECKPKYGVFVPIAKVSLSPSSKKT--RLSRTGSRESLTSIGTMNSIATTATSRMRMNAQQ 349
            .:|||||..|||:|||||||:||||::||  ||||..|:|||.|:.||:|||||||||:||:| |
Mosquito   388 GVRYFECPAKYGIFVPIAKVTLSPSARKTSARLSRANSKESLNSLATMSSIATTATSRLRMSA-Q 451

  Fly   350 RKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVIIFTDT 414
            |||:....|  :||||.||:||:|||||.|:|:||.||::|||:..||::..||||.:
Mosquito   452 RKSTVSAVP--STPKSSFSLQDVLREKQNHIEQLMQEREIDREETANQSIMYQKNIQQ------- 507

  Fly   415 MYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNR 479
                                                                             
Mosquito   508 ----------------------------------------------------------------- 507

  Fly   480 QPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFC 544
                                             ||.::..||.:|.:|:::.|:||.|:|||.||
Mosquito   508 ---------------------------------LKEKVTLLEKSLADEKRRNEDLQFSVDEATFC 539

  Fly   545 GDELN--------AQSQVYKEKIHDLESKITKLVSA---TPSLQSILPPD--------------- 583
            |:|||        ||:||:||||.|||:::....:|   ....|..:||:
Mosquito   540 GEELNGKIQNSVRAQTQVFKEKIADLEAQLAASGTAGKPNEPTQPGVPPEEINAVRAELNAEIDK 604

  Fly   584 -----LPSDD---------GALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQRLRENVKYL---- 630
                 |..|.         .:|:.||..|.||:...::...|:::.....|:.|:|.:.||
Mosquito   605 LKAEILAKDQKLHLTEELKRSLENEIQNLHEKVADAERAAASKLSALTISEECLKEQINYLEHRV 669

  Fly   631 ----------------------------NEQIATLQSELVSKDEAL----EKFSLSECGIENLR- 662
                                        .|::|.||.||.||.:.|    ::..|.|..:|.||
Mosquito   670 DEQSDQLTVKDAELEKQYLALKNAESEQEERLAALQDELRSKKDLLAERDQQVQLLEQTVEELRA 734

  Fly   663 ----RELELLKEENEKQAQ-EAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDEC 722
                |:|:.::.|::.:|: :.|...:.|||||..|   |...|..:.|:...||.:..|.|...
Mosquito   735 DVRQRDLKTVELESDLRAKLQEQGTSSSKLAEKLSE---LEVALVEVNASKTHLERDLTNATQTI 796

  Fly   723 EILQTEVRMRDEQIRELNQQLDEVTTQLNVQ---KADSSALDDMLR--LQKEGT--EEKSTLLEK 780
            ::|:.:..::::..:|:..:|......|..:   :.:..:|...|:  ||...|  |..:.||..
Mosquito   797 KVLEEDRSVKEKAAQEVESKLTASEAALKAEIAARQEQESLAQKLQRDLQSLATSGESSAALLAA 861

  Fly   781 TEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQ-----EKLVREM------TENAINQIQLEK 834
            .:.||....:|..:...:|.::::::|.|:|..||     |:|:.|:      ..|.|.:::.:.
Mosquito   862 KQDELSNQAKQLQELEAEKVKVQQELSSLQQKFEQSRTEHEQLIAEVHALADAERNTIAELRKQL 926

  Fly   835 ESIEQQLALK--------------QNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKK 885
            ::.||:...|              ||||::....::.....|..|||....||..|....:....
Mosquito   927 QTSEQENLAKDKQLEENEVLVSALQNELKELNVSKASLNQELTAIKASFADKDGTLANILQEKTA 991

  Fly   886 LQQQLEQ-KTLGHEKLQAALEELKKEKETIIKEKEQEL----QQLQSKSAE---SESALKVVQVQ 942
            |::|||: |.....|::...|:|:..::|:.||.|...    |||.:|..|   ...|.:.:|.|
Mosquito   992 LEKQLEESKQELASKVKQLEEDLRNREDTLRKELELSASTAQQQLSAKEEELTRLSQAREELQKQ 1056

  Fly   943 LEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEA 1007
            ||..|||.    ::.|..:.:..|.|:...::::....:|.|.:|.|.:|.:||...|..|.|.|
Mosquito  1057 LETAQQQM----KDVSDKMKQAEDTIATQTNESQSLNQQLSSLRSELSSKDEQLAKLNAVLAETA 1117

  Fly  1008 -------KKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAE 1065
                   ||.|...||..||:.|           |.|:..|...||..:|.::
Mosquito  1118 AREEAGGKKLGEAAEQYGKLEIE-----------HADLRRKMDALEQKSAQVQ------------ 1159

  Fly  1066 ASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKEL 1130
                |.|:     .|..||..:|||:...:::|:|.:||:         ||         |::.|
Mosquito  1160 ----QQKL-----DLERELDLQRSSTLDSNSELAKLTDEL---------KA---------KQRAL 1197

  Fly  1131 QELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLE 1195
            .|||       ||...||.|.||:.....::...|||:|.:.:.|..::|..     |.:||. |
Mosquito  1198 DELR-------DSYDTLKIETERRADESAQAHAALQEQVERVRQEMQQISDQ-----KIIQEN-E 1249

  Fly  1196 ITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELF 1260
            : |.||:..:::|.::..                 |:..|.|||....| .:.::.::.|..||
Mosquito  1250 L-NTELRKIKELAEQEQD-----------------NLVRTIAELKVSFE-QERQRIDSEHAAEL- 1294

  Fly  1261 EMEADMNSERLIEKVTGIKEELK----ETHLQLDE---RQKKFEELEE-KLKQAQQSEQKLQQES 1317
               |...||| .:::..:|.||:    |...||::   ..||.:||.| .::.|::.|:.||::.
Mosquito  1295 ---AKSVSER-EQQMAAMKSELESALGELKAQLEDARTESKKLQELNETAVRAAKEQEESLQKQL 1355

  Fly  1318 QTSKEKLTEIQQSLQELQDS-----------VKQKEELVQNLEEKVRESSSIIEAQNTKLNESNV 1371
            |.|:::.:.:||.|.||:.|           :.||.:.:..||:::.|..::::.::.::.|...
Mosquito  1356 QQSQDESSTLQQRLDELRQSMEQGSQDLTVQIDQKAQRIVELEQELDEQRTLLQKRSAEVAEMVA 1420

  Fly  1372 QLENKTSCLKETQDQL------LESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVE---- 1426
            :||.......|...||      :|:.||.|...|||.      ||||:...|:..|..::|
Mosquito  1421 KLEENGKSYAEMLQQLQESYTQIEALKKAKSESEEAC------QQVQQRLQDLNSSYSEMEEEQV 1479

  Fly  1427 -----------ELVKVLEEKLQAATSQ---LDAQQATNKELQELLVKSQENEGNLQGESLAVTEK 1477
                       ||.::.|:..|||..|   .||..:.|:||.:.|..:...:|..:.|.:|:.::
Mosquito  1480 DLVSREETLRKELAQLQEQMQQAAGEQKERYDAVVSKNEELLKQLESTSSAKGATETELIALRQE 1544

  Fly  1478 L------------------------QQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQKK 1518
            |                        ..|||....|::::..|:..:.||.||:::    |:.|..
Mosquito  1545 LATKSTSLGELHAKVEELNAQLQTKATLEQQVQSLEQSVSAKDASILELSGKVED----LQRQTT 1605

  Fly  1519 SHN-EIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSL--------------QQKQLL 1568
            |.: :|.:|.|:.:|    ||..::....||..|:|..|.:||:|              .:.|..
Mosquito  1606 SSDAKIVEKEEELKQ----LQTTSASKDTQLKDLQQQLEAMQKTLADSTELSKRTAVEASELQAA 1666

  Fly  1569 LEKGN------------------EFDTQLAEYQKVIDEMDD----------------------AA 1593
            |||..                  |.:|:||......||:.|                      ..
Mosquito  1667 LEKSRTTVKEQEDRQKEQQRRIAELETKLAAQATQFDELLDRKKSAETEYSHRTHDLSQKLLELE 1731

  Fly  1594 SVKSALLEQLQNRVAEL---------ETA--LRQANDAQKTAY--------LETKELRRQLESLE 1639
            |.|...:::||.|:|||         |||  :......:|..:        ||.:|...||.:..
Mosquito  1732 SAKKQEIDELQQRLAELMQRVETQVSETAQTVSSKRAVEKRQHELECAKKDLELRETELQLANRR 1796

  Fly  1640 LEKSREVL---------------------SLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNS 1683
            |||..|.|                     :..|..:|:......|...||.: :.|.|:|:||||
Mosquito  1797 LEKDNEQLRSQLVLKESELTKLAKAATAAATAADNSGSVPNRAVGVMSESKE-DDSGAQIDFLNS 1860

  Fly  1684 IIADMQQKNDALKAKVQTLETLPMDFTKPHAFDALTKRKPAPRLFCDICDEFDQHDTEDCPIQGS 1748
            ||.|||:||:.|..::|.||:...| :...:|| :.|||||||:|||||||||.|:|||||.|.|
Mosquito  1861 IIVDMQRKNEKLTLRIQALESTSAD-SHNMSFD-IQKRKPAPRVFCDICDEFDLHETEDCPKQCS 1923

  Fly  1749 EDQDYSTPSSESNNNE-KERKLPAPRKYCDSCEVFGHDTSECADDETY 1795
            :    |.|.|..:.:: ||||:|.|||||:|||||||:..||.|||||
Mosquito  1924 D----SPPESLKHPSDGKERKVPPPRKYCESCEVFGHEIGECPDDETY 1967

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	45/208 (22%)
		CAP_GLY	125..189	CDD:460154	53/63 (84%)
		CAP_GLY	239..306	CDD:460154	53/66 (80%)
		SMC_prok_B	<546..912	CDD:274008	112/480 (23%)
		SMC_prok_B	743..1596	CDD:274008	247/1021 (24%)
		COG4913	<1534..>1703	CDD:443941	64/262 (24%)
		CLIP1_ZNF	1726..1743	CDD:465212	13/16 (81%)
		CLIP1_ZNF	1773..1789	CDD:465212	11/15 (73%)
CLIP-190	XP_061513552.1	None