Protein Alignment CLIP-190 and DCTN1-p150

DIOPT Version :10

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: XP_061503523.1
• Gene: DCTN1-p150 / 1274028
• VectorBaseID: AGAMI1_006352
• Length: 1290
• Species: Anopheles gambiae
• Alignment Length: 1650
• Identity: 356/1650 - (21%)
• Similarity: 610/1650 - (36%)
• Gaps: 578/1650 - (35%)

  Fly   121 EQFI-IGQRVWLGGTR-PGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIF 183
            |::: |||||.|.|.. .|.||::|.|.||.|:|.||:|||..|||:|.:.|.:||.||...|:|
Mosquito     3 ERYLKIGQRVELTGKEVRGTIAYVGMTSFAVGKWVGVILDEAKGKNNGSIKGHQYFSCEENYGMF 67

  Fly   184 SRLTRLTTY-----PLAGAQTP-TSPLAKSSPDRSRTVSPTASIRSSMLRSPGIGGKNGMAVGDR 242
            .|.|:|...     |:..|||| ..|.::.|..:..|...||....|:...||
Mosquito    68 VRPTQLVFIDDAGNPIEDAQTPDEKPRSRLSSAKRATGRVTAGSVRSLASMPG------------ 120

  Fly   243 VIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVS 307
              .:..|.::|..:|     :.:|       :.:|..|.....                    ::
Mosquito   121 --STQTFSAKPTAVR-----RKSP-------VKQPQTKRASMT--------------------MT 151

  Fly   308 LSPSSKKTRLSRT----GSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFS 368
            ||.||.:..|:|:    ||:..|||.|:           .|.:.|   ||.|. |:.:.|
Mosquito   152 LSTSSSRMSLNRSTSSLGSKTQLTSPGS-----------ERASGQ---SSIPT-PVSSIP----- 196

  Fly   369 MQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPSKK 433
                                                         ||..|    ||:.|.
Mosquito   197 ---------------------------------------------TMVKP----DRNEPL----- 207

  Fly   434 SRVKVPQQQHIWVPTTLSSSITTS-------TSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLH 491
                  |:.|:..|.:|.:|...|       .:.:|......:..:.:.|....|.....:..:|
Mosquito   208 ------QRSHMSPPESLQTSKRASFVETGFVETLKPQFTPGQSLISPSPAPTPAPGASSTEDRIH 266

  Fly   492 QKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDEAQFCGDELNAQSQVYK 556
                                     |::|::.|:..||                  |||
Mosquito   267 -------------------------ILQLQAELEEMRK------------------LNA------ 282

  Fly   557 EKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQQKEVESRIAEQLEEEQ 621
                ||..|:.                                   |::|:..|.|        :
Mosquito   283 ----DLGEKLE-----------------------------------TLKQRRAEDR--------E 300

  Fly   622 RLRE--NVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKEENEKQAQEAQAEFT 684
            ||||  .:|...||:...:|:::...             ..|:|:|:..|:| .|.|.||:...:
Mosquito   301 RLREFDKMKTQYEQLVEFKSKIMDAH-------------SQLQRDLQRAKQE-AKDAIEARDLHS 351

  Fly   685 RKLAE--KSVEVLRLSSELQNLKATSDSLE----SERVNK-TDECEILQTEVRMRDEQIRELN-- 740
            .::||  ::||::.|..|:...||.:.:||    .||:.: |.:.|||:||::   |::..:.
Mosquito   352 EEMAELAENVELITLDKEMAEEKADTLALELETAKERIEELTLDLEILKTEMQ---EKVGSIGGG 413

  Fly   741 -----------------QQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQS 788
                             :||::...:|.         :.::||:.....||.. ::|.||||...
Mosquito   414 GGAGAGDGSAVASTYEFKQLEQQNARLR---------ETLVRLRDLSAHEKHE-IQKLEKELETK 468

  Fly   789 KEQAAKTLNDKEQLEKQISDLK-QLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQ 852
            |.:..:....||:...:|.:|: ||.:    ::|..:.|     |..|.:.:|||.|:.||||..
Mosquito   469 KSEVTELQRTKEKFSAKIDELEAQLGD----LQEQVDAA-----LGAEEMVEQLAEKKMELEDKV 524

  Fly   853 KKQSESEVHLQEIKAQNTQKDFELVESGESLK-KLQQQLE-----QKTLGHEKLQAALEELKKEK 911
            |...|....|:.::..:.|    ||||...|: .::::|:     ::....|| .||||.:....
Mosquito   525 KALEEEVAELEALEEVHEQ----LVESNHELEMDMREELDMAHAAKREAVREK-DAALETIVDRD 584

  Fly   912 ETIIKEKE---------QEL------------QQLQSKS--------------AESESALKVVQV 941
            :||:|.:|         |||            ||.|:|.              |||::..:.:.:
Mosquito   585 QTILKFRELVQRLNEQCQELRERLNQESSKQQQQQQAKDTALITETIDFKQMFAESKAFTRAIDL 649

  Fly   942 QLEQLQ-QQA----------------AASGEEGSKTVAKLHDEI----SQLKSQAEETQSELKST 985
            ||.|:: .||                |..|:..:..|..|...|    ..:.|||.|..|.:.
Mosquito   650 QLRQIELTQANEHVRYLTAFMPDVFMARGGDHDAILVILLVSRIVFKSGIIVSQARERFSSVP-- 712

  Fly   986 QSNLEAKSKQLEAANGSLEEEAKKSGH----------LLEQITKLKSEVGETQAALSSCHTDVES 1040
                            .::..|..|||          ||..:..|:|.:.:...:::.|..|
Mosquito   713 ----------------QMDRVAILSGHEVAQFGFRSRLLHHVHNLQSIMHQFLFSMTGCKAD--- 758

  Fly  1041 KTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFS--- 1102
                      .|.|:.....|..|:    :..|.||.|.|.|....|.||:..|...::.|:
Mosquito   759 ----------TLLKIGAALPEMLAQ----EKMVDEIVDLLKANQLDENSSTDNLEKCVTFFNAMY 809

  Fly  1103 ---------------------------DEIATGHK---------ELTSKADAWSQEMLQKEKELQ 1131
                                       |.||....         :.||.:....|.:||   .::
Mosquito   810 VVLLTGEDLVNETQIVRDCTASIGAACDSIANDSNIIKILIKPGDETSDSGLLLQYILQ---NVE 871

  Fly  1132 ELRQQL--------QDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELST---GTQT 1185
            .:||||        ||...::..|.....|..|...|::..:...:..|..:.|:|.|   .|:|
Mosquito   872 NIRQQLKLVKRRLPQDVAITKCNLSMNTLRNLKRTAEALNKVMSVLFYATRQCLQLVTLDPETET 936

  Fly  1186 TIKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEK 1250
            ::.  ||:|          .::.|...:|:.:...|..:..|... :||.:.::..:.:.|
Mosquito   937 SVP--QEKL----------WEILSNGCEKVYEQDDLGPSQNVRTV-LSAASTDMGQLAQYL---- 984

  Fly  1251 SETNHIFELFEMEADMNSER-----LIEKVTGIKEELKETH---LQLDERQKKFEELE--EKLKQ 1305
              .:|.:|:.........|.     :|.:...:|::|:||.   ..|:.|:.:..:|:  .||||
Mosquito   985 --LDHEYEIISATNAAKPEEKPVAPIILRAQAVKKQLEETKTLTATLENREAEIRQLKLAAKLKQ 1047

  Fly  1306 AQQSEQKLQQESQTSKEKLTEIQQ----SLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKL 1366
            .:.||.:::::  .:::||:.:||    :...||   ||.:|:...|::|.:|
Mosquito  1048 NELSEMQIRKD--LAEKKLSVLQQDHETNTTRLQ---KQYDEVCAKLKQKEKE------------ 1095

  Fly  1367 NESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKV 1431
                         .:||.|.|   |.....|:.|.:.|..:|:.......|:|.:        ..
Mosquito  1096 -------------FEETMDHL---QSDIDSLESEKSSLRDKLKSFSSRKVDLKTT--------TA 1136

  Fly  1432 LEEKLQAATSQLDAQQAT-------NKELQELLVKSQENEGNLQG-ESLAV----TEKLQQLEQA 1484
            |:   .:|:|...||:.:       ::..:.|.|::.|....|.| |.|.|    .|::|:|||.
Mosquito  1137 LD---ISASSPYIAQELSLLKRAFKDERAERLKVQANEYRKILAGLEPLHVPQPKDERIQELEQK 1198

  Fly  1485 NGELKEALCQKENGLKELQG-KLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQL 1548
            ...:|..|.     :..::| ::..:|||..|..|:   |.|...|.:|::..::.:    ||||
Mosquito  1199 ITRVKHDLI-----MSLVKGAEIPATNTVHGSVSKT---ILDHENQRKQQQTQIRAK----AEQL 1251

  Fly  1549 SQLKQANEELQKSLQQKQLLLEKGN 1573
                 |.:.:|:.|.:|.....||:
Mosquito  1252 -----ACDVMQEYLSRKPHRAAKGD 1271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:460154	34/64 (53%)
		CAP_GLY	239..306	CDD:460154	6/66 (9%)
		SMC_prok_B	<546..912	CDD:274008	93/400 (23%)
		SMC_prok_B	743..1596	CDD:274008	214/980 (22%)
		COG4913	<1534..>1703	CDD:443941	10/39 (26%)
		CLIP1_ZNF	1726..1743	CDD:465212
		CLIP1_ZNF	1773..1789	CDD:465212
DCTN1-p150	XP_061503523.1	None