DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and Mmrn2

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_694767.3	Gene:	Mmrn2 / 105450	MGIID:	2385618	Length:	943	Species:	Mus musculus

Alignment Length:	984	Identity:	199/984 - (20%)
Similarity:	338/984 - (34%)	Gaps:	325/984 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   773 EKSTLLE-----KTEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQL 832
            :||.|:.     ||||.||.|::...:...|              .:..:::..:.:..:.|:|
Mouse    61 QKSRLVTFVAACKTEKFLVHSQQPCPQGAPD--------------CQGVRVMYRVAQKPVYQVQ- 110

  Fly   833 EKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGH 897
            :|..|    ::.......||....:.  |......:.|:...:|.|:.:|:...:       |||
Mouse   111 QKVLI----SVDWRCCPGFQGPDCQD--HNPTANPEPTEPSGKLQETWDSMDGFE-------LGH 162

  Fly   898 EKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGS--KT 960
            ...:  ..|:|..:|    ::|..||.||:.:                   |:...|..||  ..
Mouse   163 PVPE--FNEIKVPQE----QQENLLQNLQNDA-------------------QSVEDGFPGSWEAP 202

  Fly   961 VAKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVG 1025
            .:.|.||:                |::||.           ..|...:.|.|||:.
Mouse   203 PSNLTDEM----------------TEANLT-----------EFEFPGRTSEHLLQP--------- 231

  Fly  1026 ETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSS 1090
                     |.|                      |..:|..|.:.   |...|:||:..||.|:.
Mouse   232 ---------HID----------------------AFLKAHFSPIW---KNFNDSLHSLSQAIRNL 262

  Fly  1091 S---SALHTKLSKFSDEIA--TGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQDSQTKLKAE 1150
            |   .|.|..:....:...  ...:||.:|.:|   ::.|..:.|.:|.|.::|...:|
Mouse   263 SLDVEANHQAIKMIQEGTVARADFQELGAKFEA---KVQQNSQRLGQLWQDVEDQLHAQ------ 318

  Fly  1151 GERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAELQHKEKMASEDAQKI 1215
                .:|...::.::|.||:
Mouse   319 ----RRSVHHALSDVQAEVS--------------------------------------------- 334

  Fly  1216 ADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIEKVTGIKE 1280
            ..||.||:|.::..||.|...|..:..                     |....|.|..::..::.
Mouse   335 TKLKQLVKAQELPGANGSLVMASAAAA---------------------ARPEPESLQARLGQLQR 378

  Fly  1281 ELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELV 1345
            .|...|:...:|:   |||:..||   ..:..|:|.::..||..:|..::..::....:|.|||:
Mouse   379 NLSALHMVTSQRE---EELQSTLK---NMDSVLKQHAEEIKELYSESDETFDQISKVERQVEELL 437

  Fly  1346 QNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQ 1410
            .|               :|.|.|..|.|..|:..::|.::::      |:||.|    |:..||.
Mouse   438 VN---------------HTGLRELRVILMEKSLIMEENKEEI------ERQLLE----LNLTLQH 477

  Fly  1411 V----------------QEANGDI-------KDSLVKVEELVKVLEEKLQAATSQLDAQQATNKE 1452
            :                |..|.|:       :|.:..:||....|:|:.|...|.|.|.|:|...
Mouse   478 LHAGHADLIKYVKDCNCQRVNSDVDVAPEGHRDVMHTLEETQVSLDEQHQLDGSSLQALQSTVDA 542

  Fly  1453 LQELLVKSQENEG-NLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTVLESQ 1516
            :...: .:...|| ..:.|...:..:|:.|:.|    .|||....||.::....|..|.|.|...
Mouse   543 MSSAM-DAYRGEGERARAERARIRSQLRALDHA----VEALKTAANGTRKEIRLLHGSFTALLED 602

  Fly  1517 KKSH---------NEIQDKL-EQA--------QQKERTLQEETSKLAEQL---SQLKQANEELQK 1560
            ...|         .|:.|:: |:|        :|....||:..|.|.||.   ..|....|.|:|
Mouse   603 ALRHQAVLAALFGEEMIDEMSEEAPRPLPLDYEQIRLALQDAASGLQEQAIGWEDLATRVEALEK 667

  Fly  1561 S----LQQKQLLLE-------KGNEFDTQ-LAEYQKVIDEMDD-------------AASVKSALL 1600
            :    ::|...|.|       .|.|.:.. |||.::.|..:..             |||:.|: |
Mouse   668 AAGGFVEQHPQLAEGLEPSHDSGREEEAMTLAELEQEIRRLSSDVKQIGQCCEASWAASLNSS-L 731

  Fly  1601 EQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEKSREVLSLKAQMN----GASSRSG 1661
            |.|.:.:.:.:..|||........:...:.|.....||:|.|.:.:||.|.:..    |.|.:..
Mouse   732 EDLHSMLLDTQHGLRQHRQLFHNLFQNFQGLVASNISLDLGKLQAMLSKKDKKQPRGPGESRKRD 796

  Fly  1662 KGDEVESLD 1670
            |...|.|.|
Mouse   797 KKQVVMSTD 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:396049
		CAP_GLY	239..306	CDD:396049
		SMC_prok_B	<546..912	CDD:274008	27/143 (19%)
		Smc	734..1591	CDD:224117	175/886 (20%)
		SHE3	1502..1702	CDD:293683	53/219 (24%)
		CLIP1_ZNF	1773..1789	CDD:406934
Mmrn2	NP_694767.3	EMI	56..126	CDD:284877	15/83 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..150		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..801		6/22 (27%)
		C1q	821..940	CDD:278798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000