DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and clip1b

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_021335153.1	Gene:	clip1b / 100537790	ZFINID:	ZDB-GENE-111111-7	Length:	862	Species:	Danio rerio

Alignment Length:	1782	Identity:	353/1782 - (19%)
Similarity:	528/1782 - (29%)	Gaps:	962/1782 - (53%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVL 116
            :||.:|.|         ||||:|.   |.|....|    ||...::..:.||...|.:|
Zfish     5 KPSGIKPP---------SKIGKPA---TAPTKTSP----TSAGAKAVTSPSSAQDAASD------ 47

  Fly   117 TANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRG 181
                  |.:|:|||:.|.:||.:.|:|.|.||.|:|||:|||||.|||||.|||.|||||:...|
Zfish    48 ------FSVGERVWVNGNKPGLVQFVGGTQFAPGQWAGIVLDEPIGKNDGSVSGVRYFQCKDLYG 106

  Fly   182 IFSRLTRLTTYPLA-----GAQTP-----------------TSPLAKSSPDRSRTVSPTASIRSS 224
            ||:|.::||..|:.     |.|||                 |:...::|.:.:||.|.:||..|.
Zfish   107 IFTRPSKLTRSPVQEREPNGTQTPADKTSGPVKEPAAAPQTTTVNTRNSSNLTRTASESASNLSE 171

  Fly   225 MLRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIR 289
            ...:..|  :..:.:||||:|.   ||:.|::|:||||.||.|.|||||||||.|||||.|...|
Zfish   172 TDSAKKI--QRELKLGDRVLVG---GSKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGGR 231

  Fly   290 YFECKPKYGVFVPIAKV------SLSPSSKKT--RLSRTGSRESLTSIGTMNSIATTATSR-MRM 345
            ||:|.||||:|.|..||      |.:|:..|.  |.|...:..|.:|:.:::|:.::...: .|.
Zfish   232 YFQCLPKYGLFAPTHKVTRIGFPSTTPAKSKASRRRSTLKNSPSASSVSSLSSVTSSVGGKPSRA 296

  Fly   346 NAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVII 410
            ......|....:.|..|.    ::|:.|:|||||:|:|:.||||:|.:
Zfish   297 GLLTETSVRYARKISGTT----ALQEALKEKQQHIEQLLAERDLERTE----------------- 340

  Fly   411 FTDTMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAA 475
                                                                 :|.||:.|...
Zfish   341 -----------------------------------------------------VARATSHAGEV- 351

  Fly   476 ACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDE 540
                    ||:...|.|.|:|                   ..||:|:.||..|:..|
Zfish   352 --------QQELALLTQAQEQ-------------------YAVEMEAKLDQLRRLVE-------- 381

  Fly   541 AQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQ 605
                                                                          |..
Zfish   382 --------------------------------------------------------------TAD 384

  Fly   606 QKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKE 670
            :.:||  :..|||||:|..|::::
Zfish   385 RDKVE--LMNQLEEEKRKVEDLQF----------------------------------------- 406

  Fly   671 ENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDECEILQTEVRMRDEQ 735
                                                   .:|...:.|.|    |:|:.::....
Zfish   407 ---------------------------------------RVEEACITKGD----LETQTKLEHAH 428

  Fly   736 IRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDKE 800
            |:||                                 |:|.|.|||:.              ||.
Zfish   429 IKEL---------------------------------EQSLLFEKTKA--------------DKL 446

  Fly   801 QLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVHLQ-- 863
            |.|.:.:.:..::|:.::           ::||||                     .|::|||
Zfish   447 QRELEDTRVATVSERSRI-----------MELEKE---------------------VSDLHLQLR 479

  Fly   864 EIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQSK 928
            .::|:.         ||.:...||.:             .::||..|.||    :::||..||.|
Zfish   480 TLRAET---------SGSASPPLQDK-------------KIKELNSELET----RQKELIFLQQK 518

  Fly   929 SAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEAKS 993
            .:.||.....||.||..|:||..|:.|:.:|....:
Zfish   519 LSASEEQKTSVQQQLHDLKQQFEAAEEDRNKATLAM----------------------------- 554

  Fly   994 KQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKE 1058

Zfish   555 ----------------------------------------------------------------- 554

  Fly  1059 YAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEM 1123
                                                                          |||
Zfish   555 --------------------------------------------------------------QEM 557

  Fly  1124 LQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIK 1188
               |.:||..|.||:|.:..|   |.|.|||.                  |:|
Zfish   558 ---EMKLQTERNQLEDLRREQ---KKEEERKH------------------TQN------------ 586

  Fly  1189 DLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSET 1253

Zfish   587 ----------------------------------------------------------------- 586

  Fly  1254 NHIFELFEMEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQ 1318
                                                          :||||...|..::||::.:
Zfish   587 ----------------------------------------------DEKLKLTTQRNEELQEQLE 605

  Fly  1319 TSKEKLTEIQQSLQELQDSVKQK-EELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKE 1382
            ..|::.|:||..|....:.::|: |||..|   .|:..:|:.|.|.|...:.::.:...::.|..
Zfish   606 LLKQQNTQIQDQLSSETERLRQQIEELKLN---AVQRQASLQEEQGTLTEQLDITVRENSNALMS 667

  Fly  1383 TQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLDAQQ 1447
            .:|:.||      .|:.|.|.|.||                                       .
Zfish   668 DKDKELE------MLRNEIAALRGE---------------------------------------N 687

  Fly  1448 ATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDESNTV 1512
            |..|.|:.                 |||
Zfish   688 AMTKTLKS-----------------AVT------------------------------------- 698

  Fly  1513 LESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDT 1577
                                   :|:|:.::|.|::           |||:||
Zfish   699 -----------------------SLEEDKAELLERV-----------KSLEQK------------ 717

  Fly  1578 QLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLELEK 1642
                                            ||  ||..:..|:::..:|     .:|.|..||
Zfish   718 --------------------------------LE--LRHTHSGQQSSTEDT-----TVEQLREEK 743

  Fly  1643 SREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLETLPM 1707
                                         |.:..:||||||:|.|:|:||:.||.|::.:..  .
Zfish   744 -----------------------------EFAEGQINFLNSVIVDLQRKNEELKVKLKKMAL--T 777

  Fly  1708 DFTKPHAFDALT----KRKPAPRLFCDICDEFDQHDTEDCPIQGSEDQDYSTPSSESNNNEKERK 1768
            :|......|.|.    |:|..||:||||||.||.|||||||.|      ..:|.|..:::.:.|:
Zfish   778 EFNGNEDNDGLVEVKKKKKAPPRVFCDICDCFDLHDTEDCPTQ------TQSPDSPPHSSYRGRR 836

  Fly  1769 LPAPRKYCDSCEVFGHDTSECADDETY 1795
             ...|.|||.||.|||.|..|.||:|:
Zfish   837 -SDERPYCDICEAFGHATESCNDDQTF 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	18/65 (28%)
		CAP_GLY	125..189	CDD:396049	38/63 (60%)
		CAP_GLY	239..306	CDD:396049	41/66 (62%)
		SMC_prok_B	<546..912	CDD:274008	45/367 (12%)
		Smc	734..1591	CDD:224117	114/859 (13%)
		SHE3	1502..1702	CDD:293683	34/199 (17%)
		CLIP1_ZNF	1773..1789	CDD:406934	10/15 (67%)
clip1b	XP_021335153.1	CAP_GLY	50..114	CDD:307465	38/63 (60%)
		CAP_GLY	184..248	CDD:307465	41/66 (62%)
		SH3_and_anchor	<307..>410	CDD:275056	43/356 (12%)
		SMC_N	<368..721	CDD:330553	137/1098 (12%)
		CLIP1_ZNF	800..817	CDD:318782	13/16 (81%)
		CLIP1_ZNF	840..856	CDD:318782	10/15 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7253
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110101at2759
OrthoFinder	1	1.000	-	-		FOG0002895
OrthoInspector	1	1.000	-	-		otm24265
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1398
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950