Protein Alignment CLIP-190 and clip1b

DIOPT Version :10

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: NP_001429563.1
• Gene: clip1b / 100537790
• ZFINID: ZDB-GENE-111111-7
• Length: 862
• Species: Danio rerio
• Alignment Length: 1785
• Identity: 346/1785 - (19%)
• Similarity: 525/1785 - (29%)
• Gaps: 968/1785 - (54%)

  Fly    52 QPSKMKAPSSFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVL 116
            :||.:|.|         ||||:|.   |.|....|    ||...::..:.||...|.:|
Zfish     5 KPSGIKPP---------SKIGKPA---TAPTKTSP----TSAGAKAVTSPSSAQDAASD------ 47

  Fly   117 TANTEQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRG 181
                  |.:|:|||:.|.:||.:.|:|.|.||.|:|||:|||||.|||||.|||.|||||:...|
Zfish    48 ------FSVGERVWVNGNKPGLVQFVGGTQFAPGQWAGIVLDEPIGKNDGSVSGVRYFQCKDLYG 106

  Fly   182 IFSRLTRLTTYPLA-----GAQTP-----------------TSPLAKSSPDRSRTVSPTASIRSS 224
            ||:|.::||..|:.     |.|||                 |:...::|.:.:||.|.:||..|.
Zfish   107 IFTRPSKLTRSPVQEREPNGTQTPADKTSGPVKEPAAAPQTTTVNTRNSSNLTRTASESASNLSE 171

  Fly   225 MLRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIR 289
            ...:..|  :..:.:||||:|.   ||:.|::|:||||.||.|.|||||||||.|||||.|...|
Zfish   172 TDSAKKI--QRELKLGDRVLVG---GSKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGGR 231

  Fly   290 YFECKPKYGVFVPIAKV------SLSPSSKKT--RLSRTGSRESLTSIGTMNSIATTATSR-MRM 345
            ||:|.||||:|.|..||      |.:|:..|.  |.|...:..|.:|:.:::|:.::...: .|.
Zfish   232 YFQCLPKYGLFAPTHKVTRIGFPSTTPAKSKASRRRSTLKNSPSASSVSSLSSVTSSVGGKPSRA 296

  Fly   346 NAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEVII 410
            ......|....:.|..|.    ::|:.|:|||||:|:|:.||||:|
Zfish   297 GLLTETSVRYARKISGTT----ALQEALKEKQQHIEQLLAERDLER------------------- 338

  Fly   411 FTDTMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAA 475
                                                 |.::.:.:.:...:..:|..|.|
Zfish   339 -------------------------------------TEVARATSHAGEVQQELALLTQA----- 361

  Fly   476 ACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCSIDE 540
                   |:|....:..|..|.: :.|...|:.|        |||.:.|:.|::|.|:||..::|
Zfish   362 -------QEQYAVEMEAKLDQLR-RLVETADRDK--------VELMNQLEEEKRKVEDLQFRVEE 410

  Fly   541 AQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEKMTIQ 605
            |.....:|..|:::....|.:||             ||:|.....:|         ||
Zfish   411 ACITKGDLETQTKLEHAHIKELE-------------QSLLFEKTKAD---------KL------- 446

  Fly   606 QKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENLRRELELLKE 670
            |:|:|......:.|..|:.|                      |||
Zfish   447 QRELEDTRVATVSERSRIME----------------------LEK-------------------- 469

  Fly   671 ENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKA-TSDSLESERVNKTDECEILQTEVRMRDE 734
                                  ||..|..:|:.|:| ||.|....                ::|:
Zfish   470 ----------------------EVSDLHLQLRTLRAETSGSASPP----------------LQDK 496

  Fly   735 QIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKTEKELVQSKEQAAKTLNDK 799
            :|:|||.:                                   ||..:|||:..:::.:.:...|
Zfish   497 KIKELNSE-----------------------------------LETRQKELIFLQQKLSASEEQK 526

  Fly   800 EQLEKQISDLKQ---LAEQEKLVREMTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVH 861
            ..:::|:.||||   .||:::          |:..|..:.:|.:|..::|:|||.:::|.:.|
Zfish   527 TSVQQQLHDLKQQFEAAEEDR----------NKATLAMQEMEMKLQTERNQLEDLRREQKKEE-- 579

  Fly   862 LQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQ 926
                :.::||.|                                    ||..:..::.:|||:
Zfish   580 ----ERKHTQND------------------------------------EKLKLTTQRNEELQE-- 602

  Fly   927 SKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNLEA 991
                           |||.|:||.....::.|....:|..:|.:||..|.:.|:
Zfish   603 ---------------QLELLKQQNTQIQDQLSSETERLRQQIEELKLNAVQRQA----------- 641

  Fly   992 KSKQLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVN 1056
                      ||:||   .|.|.||:
Zfish   642 ----------SLQEE---QGTLTEQL--------------------------------------- 654

  Fly  1057 KEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQ 1121
                              :||         .|.:|:||
Zfish   655 ------------------DIT---------VRENSNAL--------------------------- 665

  Fly  1122 EMLQKEKELQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTT 1186
             |..|:|||:.||                                .|:...:.||
Zfish   666 -MSDKDKELEMLR--------------------------------NEIAALRGEN---------- 687

  Fly  1187 IKDLQERLEITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKS 1251
                                         |..|||..|:               |.||..:||
Zfish   688 -----------------------------AMTKTLKSAV---------------TSLEEDKAE-- 706

  Fly  1252 ETNHIFELFEMEADMNSERLIEKVTGIKE--ELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQ 1314
                               |:|:|..:::  ||:.||                  ..|||
Zfish   707 -------------------LLERVNSLEQKLELRHTH------------------SGQQS----- 729

  Fly  1315 QESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSC 1379
                                                                             
Zfish   730 ----------------------------------------------------------------- 729

  Fly  1380 LKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATSQLD 1444
              .|:|..:|..::||:..|
Zfish   730 --STEDTTVEQLREEKEFAE--------------------------------------------- 747

  Fly  1445 AQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKELQGKLDES 1509
                                                                             
Zfish   748 ----------------------------------------------------------------- 747

  Fly  1510 NTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNE 1574
                                                                             
Zfish   748 ----------------------------------------------------------------- 747

  Fly  1575 FDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLESLE 1639
                                                                             
Zfish   748 ----------------------------------------------------------------- 747

  Fly  1640 LEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTLET 1704
                                                .:||||||:|.|:|:||:.||.|::.:..
Zfish   748 ------------------------------------GQINFLNSVIVDLQRKNEELKVKLKKMAL 776

  Fly  1705 LPMDFTKPHAFDALT----KRKPAPRLFCDICDEFDQHDTEDCPIQGSEDQDYSTPSSESNNNEK 1765
              .:|......|.|.    |:|..||:||||||.||.|||||||.|      ..:|.|..:::.:
Zfish   777 --TEFNGNEDNDGLVEVKKKKKAPPRVFCDICDCFDLHDTEDCPTQ------TQSPDSPPHSSYR 833

  Fly  1766 ERKLPAPRKYCDSCEVFGHDTSECADDETY 1795
            .|: ...|.|||.||.|||.|..|.||:|:
Zfish   834 GRR-SDERPYCDICEAFGHATESCNDDQTF 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	18/65 (28%)
		CAP_GLY	125..189	CDD:460154	38/63 (60%)
		CAP_GLY	239..306	CDD:460154	41/66 (62%)
		SMC_prok_B	<546..912	CDD:274008	61/369 (17%)
		SMC_prok_B	743..1596	CDD:274008	94/857 (11%)
		COG4913	<1534..>1703	CDD:443941	14/168 (8%)
		CLIP1_ZNF	1726..1743	CDD:465212	13/16 (81%)
		CLIP1_ZNF	1773..1789	CDD:465212	10/15 (67%)
clip1b	NP_001429563.1	None