DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CLIP-190 and cep350

DIOPT Version :9

Sequence 1:	NP_001368962.1	Gene:	CLIP-190 / 35042	FlyBaseID:	FBgn0020503	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_005166971.1	Gene:	cep350 / 100004437	ZFINID:	ZDB-GENE-030131-6975	Length:	3060	Species:	Danio rerio

Alignment Length:	2160	Identity:	410/2160 - (18%)
Similarity:	740/2160 - (34%)	Gaps:	641/2160 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSAPFPSPVTADPEPGATASKL-PGPI---------------RSNIPTPATSGTGIPQPSKMKAP 59
            |.:| |.||..:.|..::...: .||:               ||.:.|...:| |......:...
Zfish   871 TPSP-PKPVVEEVELDSSGGSISEGPLLSEGCISDDDMQELPRSRLTTAGFNG-GYMNGESLNPI 933

  Fly    60 SSF------------------GSTGSVSKI--GRPCCNHTT------------------PKSGPP 86
            |.|                  ||.|...::  |.|   |:.                  .||.|.
Zfish   934 SRFQIEAEKQPPFSSLSLVQGGSNGPWEELAKGSP---HSVINIFTKNMGYGKAFEERGGKSSPA 995

  Fly    87 PREATSMSRESD-----DNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPGQIAFIGDTH 146
            .|...|.:...|     |:.  |:|..:..|::..:.|      |....||...|......|.:.
Zfish   996 VRSVLSGASSLDGIVYEDDF--ISSRASSQSASKRSPN------GLSNGLGHFSPPDDVLSGRSA 1052

  Fly   147 FAAGEWAGVVLDEPNGKNDGCVSGKRYFQ---CEPKRGIFSRLTRLTT--YPLAGAQTPTSPLAK 206
            ::........|...:..:....|.||..:   .|.:|..||.::.|..  :..:|::..:|..:.
Zfish  1053 YSNRAQRSPALTPLSSPHSASSSSKRASERSLQEGQRNTFSAISDLPAEGFKKSGSEKASSRSSH 1117

  Fly   207 SSPDRSRTV------------------SPTASIRSSMLRSPGIGGKNGMAVGDRV---------- 243
            .|.|...|:                  ||.:::.:....||...|.:.::.||.:
Zfish  1118 RSVDTDSTLGGISIHSIHSLFGSEGKKSPRSALATPAAASPASSGSSRLSPGDCIPSKGSVQGSG 1182

  Fly   244 -----IVSSGFGSRPGIL-----------------RYLGETQFAPG---NWCGVELD-----EPS 278
                 :.||...|...:.                 |...|.:||||   .....||:     |.|
Zfish  1183 SPHAALPSSSSSSSSAVRAKSNPSPHTQSPGRTEHRTTAELKFAPGVLHQRLSAELNYLDAVEES 1247

  Fly   279 GKNDGTVDDIRYFECKPKYGV------FVPIAKVSLSPSSKKTR----LSRTGSRESLTSIGTMN 333
            .:..|.|:.:|        ||      .|.:|::..|...:..|    |.....:|:|.   |..
Zfish  1248 VRQLGDVERVR--------GVSLAQQETVSLAQILKSQQQRHERDLYLLRMKAEQEALE---TQM 1301

  Fly   334 SIATTATSRMRMNAQQRKSSTPVKPIL------------ATPKSQFSMQDLLR---EKQQHVEKL 383
            .:..:.....|::|:.::|      :|            ||.|......:..|   |..:|::::
Zfish  1302 QLEESRQKAARVHAELQES------LLQSQQQALGGLHEATNKMINQQAEAARHTAETARHIKEM 1360

  Fly   384 MVERDLDR-----------------EDAQNQALQLQKNINEVIIFTDTMYAPLPYADRSRPYRPS 431
               .:|.|                 .|.|.|..:..|. ::....||:     .:.....|.|..
Zfish  1361 ---TELARSQIVGALSVPGPSITALHDQQRQHSRSSKP-HQTQTHTDS-----SWKSEMSPERHQ 1416

  Fly   432 KKSRVKVPQQQHIWVPTTLSSSITTSTSTRPTIAAATAAAAAAAACNRQPLQQQQQPHLHQKQQQ 496
            ..|.|:.|       |.:||.||   .|.||||:...:::.           |...||..|.:::
Zfish  1417 SPSEVETP-------PDSLSESI---PSRRPTISGGGSSST-----------QLSPPHSGQTERR 1460

  Fly   497 AKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQCS------IDEAQFCGDELNAQSQVY 555
            ...|     |:..           .|..|......::..||      ::|...|.......|..:
Zfish  1461 TPGK-----DRSS-----------SSVEDQAHTAADDSLCSNSVLGPLEEKADCASIATEYSVKF 1509

  Fly   556 KEKI--HDLESKITKLVSATPSLQSILPPD--------------LPSD----------------D 588
            .:.:  .|:|.:         |.:|:||.:              |.||                |
Zfish  1510 DDSMTEDDIEER---------SFRSLLPSEAHRRESLDKKPEAHLESDEDHNHDQSSPRASTKQD 1565

  Fly   589 GAL-----QEEIAKLQEKMTIQ-QKEVESRIAEQLE----EEQRLRENVK----YLNEQIATLQS 639
            |::     |:..:|....:..| .||.|.|...|..    .|:.|||..|    :|..|...|:.
Zfish  1566 GSMPFSSGQDSFSKFTMDLVRQYMKEEEVRAQHQSSLLRLREKALREKTKAEVAWLEHQKRRLRD 1630

  Fly   640 ELVSKDEALEKFSLSECG----IENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSE 700
            :  .:|:.:......:.|    ::..:.|::.|:|.|:...:|.|.            :|:...|
Zfish  1631 K--GEDDKMPPLRKKQRGLIMKLQQEQAEIKRLQEANKAARRERQL------------LLKQQEE 1681

  Fly   701 LQNLKATSDSLESERVNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQ--------LNVQKADS 757
            ::.::.|:..|: ||:....:     |::......:.|.:.....:.|.        ::|..:::
Zfish  1682 IERMRHTTLKLK-ERLKTAGD-----TKMESPVSGVAESSAPPSVIVTDADTRSPSPMSVSGSET 1740

  Fly   758 SALDDMLRLQKEGTEEKS---------------------------------------TLLEKTEK 783
            |::...|:..:...:||.                                       ..|.|.|:
Zfish  1741 SSIMQKLKKMRSHMDEKHCSPVHYFFSVFTAHHWASLSVCLPNLHPKFQLFIYSQLVRFLTKREQ 1805

  Fly   784 ELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQLALKQNEL 848
            :|:|.:..|.:.|..:::|:.:.::::::.:|.....|..:...::.|.::.|       ::||.
Zfish  1806 QLMQRRRHAEELLEWRQRLDVEEAEVRRMEKQALAAWEKQQQPRSRTQTQQHS-------RENEH 1863

  Fly   849 EDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGH--EKLQAALEELKKEK 911
            ......||...   ||..:::.......|.|..:...:.:||...:...  .:|.:|:.:.....
Zfish  1864 SHTSGGQSPIG---QEAGSEDDDSVALSVSSVHTDLSVPEQLGSPSSDRPVSELNSAVVDALYSA 1925

  Fly   912 ETIIKEKEQ------ELQQLQSKSAE------SESALKVVQVQLEQLQQQAAASGEEGSKTVAKL 964
            |.|..:.:|      .|..|:...:.      ..|:...:||             ..|||| ::.
Zfish  1926 EFIATDSKQSPPGKASLSSLRHSDSSRPGTVTGTSSCSKMQV-------------HSGSKT-SEP 1976

  Fly   965 H--DEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKK---------SGHLLEQIT 1018
            |  |..|...|:....||:::|....|:.:.::.::....|::|.||         ...||:|:.
Zfish  1977 HTSDTHSATPSETTSDQSDIESRIHALKDELRKRKSVVYQLKKEQKKRQKERLKAQEASLLKQLE 2041

  Fly  1019 KLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVN-KEYAESRAEASDLQDKVKEITDTLHA 1082
            .....:.:|:|.||.......:...|::...:|.||.. |.....|.|.|   ...|.:|::..:
Zfish  2042 SYNDFIQKTKAELSKGPDGTPATKPQIKTPTSASEKPRIKPPPLQRPETS---KNWKIVTESEKS 2103

  Fly  1083 ELQAERSS---SSALHTKLSKFSDEIATGHKELTSKAD---AWSQEMLQKEKELQELR-----QQ 1136
            |:....:|   .....:.|.|:|.|    |.:::|..|   .....::...:.:..||     .:
Zfish  2104 EIVPSETSGDKDDVAPSGLQKYSSE----HDDISSDEDPPTVTPTPIMGSPEHMDVLRSFHSSDR 2164

  Fly  1137 LQDSQDSQTKLKAEGERKEK----SFEESI-----KNLQEEVTKAKTEN-------------LEL 1179
            |....:..:.:|....:.|.    |.|||:     ..:.||:..|.:|.             |.|
Zfish  2165 LSHRSNDASLVKEHSAKPEDTDFLSGEESVVSSLKSGVMEELEYANSEGSENDPSDQHSHPLLNL 2229

  Fly  1180 STGTQ-TTIKDLQERLEITNAELQHKEKMASED-AQKIA--DLKTLVEAIQVANANISATNAELS 1240
            ..|.| .::||:..:.:        ||:::.:| |.|.|  |...:.|::::..:|:|.  .|:|
Zfish  2230 DLGLQMPSLKDVNAKSD--------KERLSEKDTADKPAFQDSADVGESMRLTESNLSP--VEVS 2284

  Fly  1241 TVLEVLQAEK--SETNHI----FELFEMEADMNSERLIEKVTG--------------IKEELKET 1285
            ..::...|.|  |..:|.    |.|.:.| |....:..:..||              :..|.|.|
Zfish  2285 KHIDYPSARKTISVIDHSYTSDFSLAKRE-DSTRMKKTQSPTGDGYNDDFESSFESSLNHESKPT 2348

  Fly  1286 HLQLDE-RQKKF--------EELEEKLK-QAQQSEQKLQQESQTSKEKLTE-----IQQSLQELQ 1335
            .....: ::|.|        ||:||:|. |:..:....|.||:.....|..     |..|.|...
Zfish  2349 SPTAPQPKEKSFKSPIYSSEEEIEEELSVQSGSTNGNFQTESRPDLNSLGRGSKDVIGPSPQPQV 2413

  Fly  1336 DSVKQKEELV------QNLEEKVRESSSIIEAQNTKLNE--SNVQLENKTSCLKETQDQLLESQK 1392
            ..:..|:||.      :.|...|:..:...:.|....|.  :.|:|:|.......|.|.:...:.
Zfish  2414 PILPIKDELPSFCIGDRVLVSNVQPGTLRFKGQTNFANGFWAGVELDNPEGSNNGTYDGVAYFEC 2478

  Fly  1393 KEKQ-LQEEAAKLSGELQQVQEANGDIKD------------------SLVKVEELVKVLEEKLQA 1438
            :||. :.....|:| .|.:..||:.|.:|                  .|.|...|.|:.|||
Zfish  2479 REKHGIFAPPDKIS-RLPEKFEASADTEDDDSSCDDQPNRENKASEEQLEKRNLLNKIKEEK--- 2539

  Fly  1439 ATSQLDAQQATNKELQE-----------------LLVKSQEN------EGNLQGESLAVTEK--- 1477
              |.||......:.|:|                 ..:|||.|      :.|:..|    .:|
Zfish  2540 --SDLDLYPEAREPLREQGKPLELNIKQLSTGQSTFIKSQHNLDFNDIDCNIINE----CDKGPH 2598

  Fly  1478 ----------LQQLEQANGELKEALCQK-ENGLKELQGKLDESNTV-----LESQKKSHNEIQD- 1525
                      :.:||.|:.:....|... :.|..:.|.:.||...|     ||.:|...:.:|.
Zfish  2599 TVPNGGDRDIILKLEDASVDNAVPLLNNLDKGTSKKQKQEDEPPAVILDLLLEGEKSRVDGLQKS 2663

  Fly  1526 ---KLEQAQ-QKERTLQEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGNEFDTQLAEYQKVI 1586
               .:|:|. ..:|.|.....||.|..  |..|.::.||..:.|:..|...|:..      :..|
Zfish  2664 TDISIEEASLDNKRALTTLADKLVENF--LSDAVKQFQKIKKDKEEKLSAANQLK------RDFI 2720

  Fly  1587 DEMD----------DAASVKS----ALLEQLQNRVAELETALRQANDAQKTAYLETKELRRQLES 1637
            :|.|          .|:..|:    ...:..|..::..|...|..:....|:..|  ||.::|..
Zfish  2721 NEDDGLRSNNFKSRTASKTKTDTFRTFFDDDQEELSSPEHCNRPESPVLGTSGQE--ELVKRLAE 2783

  Fly  1638 LELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFLNSIIADMQQKNDALKAKVQTL 1702
            |||  |||:..:            .|||.:..|.:..|:.......  ...||:.|.:.:..:.:
Zfish  2784 LEL--SRELFDV------------LGDEQDWFDEDFGLSSRKEQQK--QKRQQQQDGISSSGEQV 2832

  Fly  1703 ET-----LPMDFTKP 1712
            :|     ||:...:|
Zfish  2833 KTPPRPELPVQLKQP 2847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	31/165 (19%)
		CAP_GLY	125..189	CDD:396049	13/66 (20%)
		CAP_GLY	239..306	CDD:396049	22/112 (20%)
		SMC_prok_B	<546..912	CDD:274008	74/464 (16%)
		Smc	734..1591	CDD:224117	210/1085 (19%)
		SHE3	1502..1702	CDD:293683	49/223 (22%)
		CLIP1_ZNF	1773..1789	CDD:406934
cep350	XP_005166971.1	RILP-like	<1583..1686	CDD:304877	24/116 (21%)
cep350	XP_005166971.1	CAP_GLY	2428..2491	CDD:279625	11/62 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D463666at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910