Protein Alignment CLIP-190 and dctn1b

DIOPT Version :10

• Sequence 1: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Sequence 2: XP_021336434.1
• Gene: dctn1b / 100003026
• ZFINID: ZDB-GENE-050419-28
• Length: 1264
• Species: Danio rerio
• Alignment Length: 1474
• Identity: 325/1474 - (22%)
• Similarity: 560/1474 - (37%)
• Gaps: 421/1474 - (28%)

  Fly   214 TVSPTASIRSSMLRSPGIGGKNGMAVGDRVIVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPS 278
            |.|.|.|..||.:.|.| ||: .:.||..|.| .|.|.| |.:.|:|.|.||.|.|.||.||||.
Zfish     8 TYSRTTSSGSSRMSSDG-GGR-PVKVGSLVEV-IGKGHR-GTVAYIGNTLFASGKWVGVILDEPK 68

  Fly   279 GKNDGTVDDIRYFECKPKYGVFVPIAKVSLSPSSKKTRLSRTGSRESLTSIGTMNSIATTATSRM 343
            |||||||...|||.|:..:|:||..:::.|......|....|  .|:|||......|.....|..
Zfish    69 GKNDGTVQGKRYFLCQENHGIFVRQSQIQLVEDGADTTSPET--PEALTSKMLKREIIEGLKSNK 131

  Fly   344 RMNAQQRKSSTPVKPILATPKSQFSMQDLLREKQQHVEKLMVERDLDREDAQNQALQLQKNINEV 408
            ....:.:|:.|
Zfish   132 VRGTKPKKAPT------------------------------------------------------ 142

  Fly   409 IIFTDTMYAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTL---SSSITTSTSTRPTIAAATAA 470
                                  ::|:..:.|:|....|...:   |:|....:|:.|:..|.|..
Zfish   143 ----------------------TRKTTTRRPKQTRAGVGVKVGSGSASAGEMSSSEPSTPAQTPL 185

  Fly   471 AAAAAACNRQPLQQQQQPHL--HQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDN-ERKKTE 532
            ||.........|.....|.:  ..|::::               |:|.:.:||..|:. :.|:||
Zfish   186 AAPVIPSPVGALPSPGAPPIPGPSKEEES---------------LRALVKDLEEKLETLKMKRTE 235

  Fly   533 ELQCSIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAK 597
            :                      |.|:.:||....:|..                   |||..:|
Zfish   236 D----------------------KAKLKELEKHKIQLEQ-------------------LQEWKSK 259

  Fly   598 LQEKMTIQQKEVESRIAE-QLEEEQRLRENVKYLNE--------QIATLQSELV---SKDEALEK 650
            :||    ||.|::.::.| :.|.::.|....:|:.|        ::|||..|:.   ::...||.
Zfish   260 MQE----QQNELQKQLKEAKREAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQLEA 320

  Fly   651 FSLSECGIENLRRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESER 715
            .:|.| .::.|..:||:||.|.|::..:.        |..|..|.:|..:...||
Zfish   321 DALKE-RVDELTMDLEILKHEIEEKGSDG--------AASSYHVKQLEEQNARLK---------- 366

  Fly   716 VNKTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEK 780
                      :..|||||....|    ..|...|..:.:..:..| |.||..||..:|:..:.||
Zfish   367 ----------EALVRMRDLSASE----KQEHGKQQKLMEKKNFEL-DALRCHKEKLQEEMKMAEK 416

  Fly   781 TEKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQ----EKLVREMTE-----NAINQI--QLEK 834
            |..||   |||...:|..:|.:|       .|.|:    |:.|||:.|     .|||::  :|::
Zfish   417 TIDEL---KEQVDASLGAEEMVE-------MLTERNLDLEEKVRELRETVADLEAINEMNDELQE 471

  Fly   835 ESIEQQLALK-QNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHE 898
            .:.|.:|.|: |.:|.....:::|..|.    .||.|..|:             ||..||   :.
Zfish   472 NARETELELREQLDLGAAGVREAEKRVE----AAQETVADY-------------QQTIQK---YR 516

  Fly   899 KLQAALEELKKE----KETIIKEKEQ--ELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEG 957
            :|.|.|:|:.:|    :|...::::|  |:...:.|.||:::..|.::::|.::  :...:..:.
Zfish   517 ELTANLQEVNRELMSQQEANSEQQQQPAEIFDFKIKFAETKAYAKAIEMELRKM--EVIQANRQV 579

  Fly   958 SKTVAKLHDEISQLKSQAEE-------------TQSELKSTQS----NLEAKSKQLEAANGSLEE 1005
            |..::.:.|  |.||.:.:.             .:|||.|.|:    .|.....|.....|::.|
Zfish   580 SLLISFMPD--SFLKHRGDHDCILALLLIPRLICKSELISKQAQEKFELTESCSQKPGMRGAVGE 642

  Fly  1006 EAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQ 1070
            ....:..|:..:|.|::.:.:.:.|||.|..||             .::|...|:|.......|.
Zfish   643 RLSFAAGLIYSLTLLQAALHKYEHALSQCSVDV-------------YKRVGSLYSELSVHERSLD 694

  Fly  1071 DKVKEITDTLHAELQAERSSSSALHTKLSKFSDEIATGH-----KELTSK-AD--AWSQEMLQ-K 1126
                .:.|.|:.:|..|..:...| ||..|:...:.:.|     ::.|.: ||  .::|..|. .
Zfish   695 ----FLIDLLYKDLLDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIRFTQSALDCM 754

  Fly  1127 EKELQELRQQLQDSQDSQT--KLKAEGERKEKSFEESIKNLQEEV--TKAKTENLELSTGTQT-- 1185
            ..|:..||..:|..||.:.  .|..:.:.......:..|.::..:  |.|......||.|.|.
Zfish   755 AVEVGRLRAFIQTGQDEEAFCVLLKDLDTSCSDIRQFCKKIRRRMPGTDAPGIPAALSFGPQVCE 819

  Fly  1186 TIKDLQERLEITNAELQHKEKMASEDAQKIADLK---------------------------TLVE 1223
            .:.|.:.:|...||.||   ::|:..||.||.|.                           ...|
Zfish   820 ALADSRRQLAWVNAVLQ---EVAAAAAQLIAPLSEHEGLPAVKLEDMAFKAAEQIYGSQGINAQE 881

  Fly  1224 AIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSER-------LIEKVTGIKEE 1281
            .::.:.:.:.||..:::|.::                  |.:.:|:|       :..:...::.|
Zfish   882 CLRQSCSVVIATMNKMATAMQ------------------EGEYDSDRPQTGISPVEVRAAALRAE 928

  Fly  1282 LKETH---LQLDERQKKFEELEEKLK-----------QAQQSEQKLQQESQTSKEKLTEIQQSLQ 1332
            :.:..   |:|::|:...:||::.||           :....|:||...|:.:.|::.:||..|.
Zfish   929 ITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSASKDADERVEKIQAILD 993

  Fly  1333 ELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQL 1397
            |....:|:|       |::..|:...::|...:|....|:|:::.|           ||.|
Zfish   994 ETDSLLKKK-------EKEFEETMDALQADIDQLESEKVELKHRIS-----------SQSK---- 1036

  Fly  1398 QEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEK--------LQAATSQLDAQQATNKELQ 1454
                       ..::...|.....:..:.......||:        ||...|.|..||.   |.|
Zfish  1037 -----------MTIESLRGSQASGIASIVTCGITAEEQKGVCAAAGLQVIDSPLLTQQI---EAQ 1087

  Fly  1455 ELLVKSQENEGN-LQGESL-AVTEKLQQLEQANGELKEALCQKENGLKELQGKLDE-SNTVLESQ 1516
            .|.:|..:||.| |:.|.: |....|..|.......:|. |:.|.....|..|.|: .:|:|  |
Zfish  1088 RLSIKHLKNENNRLKAERMRAQLASLPPLNVPKLGWREG-CRPEVLSSALYRKTDQLLDTLL--Q 1149

  Fly  1517 KKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQK 1560
            ..::.::.|      ...|:....:::|.||.::|:..|:.|.:
Zfish  1150 MSANVKVVD------ITGRSPVSPSAQLLEQTARLQSLNDTLDR 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039
		CAP_GLY	125..189	CDD:460154
		CAP_GLY	239..306	CDD:460154	35/66 (53%)
		SMC_prok_B	<546..912	CDD:274008	97/393 (25%)
		SMC_prok_B	743..1596	CDD:274008	200/927 (22%)
		COG4913	<1534..>1703	CDD:443941	7/27 (26%)
		CLIP1_ZNF	1726..1743	CDD:465212
		CLIP1_ZNF	1773..1789	CDD:465212
dctn1b	XP_021336434.1	CAP_GLY	31..96	CDD:460154	35/66 (53%)
		PRK02224	<212..>548	CDD:179385	108/459 (24%)
		Dynactin	522..799	CDD:463591	60/298 (20%)