DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrch and LRCH3

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	NP_001350816.1	Gene:	LRCH3 / 84859	HGNCID:	28637	Length:	803	Species:	Homo sapiens

Alignment Length:	828	Identity:	289/828 - (34%)
Similarity:	396/828 - (47%)	Gaps:	171/828 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHFS 76
            |||...:.....:.|| .:|||...|..||.|......|           .:|||:|.||||..:
Human     7 VAVAAAAEYSGTVASG-GNLPGVHCGPSSGAGPGFGPGS-----------WSRSLDRALEEAAVT 59

  Fly    77 GELILTNRKLKDFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPESV 141
            |.|.|:.|||::|||....:.||||..|||||||.:|:|.|...|..||.|.||.|.||.|||::
Human    60 GVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAI 124

  Fly   142 KQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLANL 206
            ..|.:||:|::..||||:||..:|.|||:||:.|||:|.|||:|:|.| :.|.:||.|.|::..:
Human   125 LNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHL-RHLMELDVSCNEIQTI 188

  Fly   207 PARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPLEIRHMSTLVELQLENNPL 271
            |:::|.|.:||.|::|.|||::||.||..|.||.||.|.|||.::|:..|::..|..:.|:||||
Human   189 PSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPL 253

  Fly   272 TSPPASLCMRGLVHVFKFLETQATKDEKGSRSGGNYDGYTTLRRAPRHNSSGNVLEASTTGSTNN 336
            .||||.:|::|.||:||:|..||.|.   :....:||     ||.....|....|.:|.....
Human   254 QSPPAQICIKGKVHIFKYLNIQACKI---APDLPDYD-----RRPLGFGSCHEELYSSRPYGA-- 308

  Fly   337 QRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNSTAATLPR-------------TLPSA 388
                 :|||:|:.|..|||||.:.||...:|.||.....:....|.|             |....
Human   309 -----LDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGV 368

  Fly   389 VH--SQADLMDA-------------------SLTSSTSTIVDESLTLSPTASPCK---------- 422
            .|  .|.|.:|:                   ||:|.....: |...:|...||.|
Human   369 EHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYI-EQRRISHEGSPVKPVAIREFQKT 432

  Fly   423 ---LSYAHSN------------SSSNGSSPDQDDDIMLDHQERTVHHANGRSGKGLGNIQTYKEY 472
               ..|.|.|            |:|:......|.::   ||.|.......|....|..:| |:|.
Human   433 EDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLEL---HQRREQLVERTRREAQLAALQ-YEEE 493

  Fly   473 KEALKQ-QRNQEISVYKQKHPNANHSPNDDEDL-------SPSPPSISNGSSSNTLPKSIMKQNS 529
            |...|| ||:..:...|||   |:.||.....|       .|.|...|..:..:.|..|:  ...
Human   494 KIRTKQIQRDAVLDFVKQK---ASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSL--SGL 553

  Fly   530 NQIGHNGNGNGSANGNGVDDVVIPKKPIQKVIP--SRITEIKPASTSDIR-----SANSSDCL-- 585
            ||:|                       ....:|  |..|.:|    ||.|     |:.:::.:
Human   554 NQVG-----------------------CAATLPHSSAFTPLK----SDDRPNALLSSPATETVHH 591

  Fly   586 --GYVKPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLG----TVKTHRSVTWNH 644
              .|..|.:..:|...:                       |.|...:.|    |.|.|.|.....
Human   592 SPAYSFPAAIQRNQPQR-----------------------PESFLFRAGVRAETNKGHASPLPPS 633

  Fly   645 DIPAEKLSFTMRREFDRQR-EETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHLANYVRPR 708
            ..|....:.::..:..||| ||.||:.|||..||.|||::||.|:.:||||||:||||||:||||
Human   634 AAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPR 698

  Fly   709 SVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELICSCEDVV 756
            ||.|||||||.|.|||||:|||||:|||||||:|||.::.:||..|::
Human   699 SVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQDNLCSPSDIL 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	30/54 (56%)
		LRR_4	124..161	CDD:289563	19/36 (53%)
		leucine-rich repeat	124..146	CDD:275380	12/21 (57%)
		leucine-rich repeat	147..167	CDD:275380	10/19 (53%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..215	CDD:275380	8/21 (38%)
		leucine-rich repeat	216..237	CDD:275380	11/20 (55%)
		leucine-rich repeat	238..260	CDD:275380	10/21 (48%)
		leucine-rich repeat	261..279	CDD:275380	10/17 (59%)
		CH	676..756	CDD:214479	57/79 (72%)
LRCH3	NP_001350816.1	leucine-rich repeat	61..83	CDD:275380	9/21 (43%)
		LRR	<77..>285	CDD:227223	102/211 (48%)
		leucine-rich repeat	84..106	CDD:275380	12/21 (57%)
		leucine-rich repeat	107..129	CDD:275380	12/21 (57%)
		leucine-rich repeat	130..145	CDD:275380	8/14 (57%)
		leucine-rich repeat	152..174	CDD:275380	13/22 (59%)
		leucine-rich repeat	175..197	CDD:275380	8/21 (38%)
		leucine-rich repeat	198..218	CDD:275380	11/19 (58%)
		leucine-rich repeat	220..242	CDD:275380	10/21 (48%)
		leucine-rich repeat	243..261	CDD:275380	10/17 (59%)
		CH	660..762	CDD:214479	60/87 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159879
Domainoid	1	1.000	123	1.000	Domainoid score	I5588
eggNOG	1	0.900	-	-		E2759_KOG0532
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1894
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46074
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm41580
orthoMCL	1	0.900	-	-		OOG6_107405
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3681
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.700