DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and lrch4

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_031754247.1	Gene:	lrch4 / 779610	XenbaseID:	XB-GENE-6454027	Length:	924	Species:	Xenopus tropicalis

Alignment Length:	876	Identity:	227/876 - (25%)
Similarity:	347/876 - (39%)	Gaps:	235/876 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHFSGELILTNRKLK 87
            |:.:|:....|.|......:..|.:...|.|         .||.|:.||||..:|.|.|:.|::|
Frog    57 AMAAGNDEEEGGGGDGDPELSRAESCQGSGS---------RRSAEKALEEAASTGVLSLSGRRMK 112

  Fly    88 DFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLDL 152
            :.||:...|.|||...||||:||.:|:|.::.....||:|.||||.:|.||.::..|..||:|::
Frog   113 ELPRSARNYDLTDITRADLSKNRLSEVPADICQLVSLESLNLYHNCLRFIPPALSNLQVLTHLNI 177

  Fly   153 RSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSLR 217
            ..|.|.|||..||.|||.||:.|||:|.:||:|:|.: .:|..||.|.|.|..||.::|.|..||
Frog   178 SRNLLPSLPPCICRLPLTVLIASNNKLGALPEEIGTM-TSLRQLDVSCNDLQALPPQMGSLGCLR 241

  Fly   218 SLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLCMRG 282
            .|:.|.|.|..||.||:.|.||.||:|.|:|..:|:..||:..|..:.||||||..|||.:|::|
Frog   242 DLNARRNQLSALPEELSELPLIRLDLSCNRITHIPVCYRHLRHLQTVILENNPLQYPPAQICLKG 306

  Fly   283 LVHVFKFLETQATKDEKGSRSGGNYDGYTTLRRAPRHNSSGNVLEASTTGST----NNQRRHQVD 343
            .||:||:|..:|. .:..|..|......|:|                ||..|    :::....:|
Frog   307 KVHIFKYLNIEAC-SKPVSELGVKLSRPTSL----------------TTCLTEEIYSSRPYGGLD 354

  Fly   344 SGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNSTAATLPRTLPSAVHSQADLMDASLTSSTSTIV 408
            ||:|:.|...||||.:                                          .|...:.
Frog   355 SGFNSVDSGSKRWSGN------------------------------------------ESADELT 377

  Fly   409 DESLTLSPTASPCKLSYAHSNSSSNGSSPDQDDDIMLDHQERTVHHANGRSGKGLGNIQTYKEYK 473
            |.||.::..|...|    ......||:..|            |.|          .::::..|.:
Frog   378 DLSLRIAGFAGDSK----QLREKLNGTEGD------------TEH----------TDVESTNEEE 416

  Fly   474 EALKQQRNQEISVYKQKHPNANHSPNDDE-----DLSPSPPSISNG-----SSSNTLPKSIMKQN 528
            |..|.....:::...::.|..:.:|..:|     ..:|||.|.:.|     :.....|::::...
Frog   417 EETKSDCGLQMTPQDKQKPEHHSTPRSEEKTMVSGAAPSPVSPTVGRPDPPTEERRRPETLLLWR 481

  Fly   529 SNQIGHNGNGNGSANGNGVDDVVIPKKPIQKVIPSRITEIKPASTSDIRSANSSDCLGYVKPQSP 593
            ..:.........:......|    .|:.:||| ||..|                  |....|.|.
Frog   482 ERERQQLQQRQEAPRRQSAD----RKESLQKV-PSNST------------------LPSAPPSSD 523

  Fly   594 MKNGTSKFNTSNGGGVQTTVG--------IVSSTTIKSPV-----SSTTKLGTVKTHRSVTWNHD 645
            :.||.:  :|:|  .:::.||        |:...::.:||     ||.::||
Frog   524 VANGPA--DTAN--RLRSQVGGFHWGEWRIMGMGSLMAPVFMFLASSPSELG------------- 571

  Fly   646 IPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHL---ANYVRP 707
             |.::.|....|......:|..|::|||.:                  ..::||.|   |..:.|
Frog   572 -PVDQCSPVRLRNCRPPIDEKALLAQLRKV------------------HALLLCPLCTPAFLLTP 617

  Fly   708 RSVASIHVPSPGVNKLTMARCRRNVD-------NFLEACRRIGVDEELICSCEDVVPQIEPQQ-- 763
            ....|...|.|..    :....|||.       .:...||              |||:...||
Frog   618 IRGRSFLPPPPRF----LVGNPRNVSFQGDLGRRWSSPCR--------------VVPEYHAQQNI 664

  Fly   764 PQLPRADDDYDADVYVQDD-----------GSISRSNDSSHLQCSDDCNS--SSNHINRVPNALA 815
            ..|.........|:.:..|           |::|.:...|....:..|.|  :|.|      .||
Frog   665 SALLTVSSASAQDIELSSDTSRLCRGEPHWGALSPNRTRSDTGAATCCKSPAASYH------PLA 723

  Fly   816 LLRTVSALIAMDENPYHQQLHHHLQLQLEQQ 846
            |..|.|.|||.     |..:...|.|.:::|
Frog   724 LFTTFSVLIAQ-----HVPVSPKLNLAVKRQ 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	29/54 (54%)
		LRR_4	124..161	CDD:289563	17/36 (47%)
		leucine-rich repeat	124..146	CDD:275380	11/21 (52%)
		leucine-rich repeat	147..167	CDD:275380	10/19 (53%)
		leucine-rich repeat	169..192	CDD:275380	11/22 (50%)
		leucine-rich repeat	193..215	CDD:275380	10/21 (48%)
		leucine-rich repeat	216..237	CDD:275380	10/20 (50%)
		leucine-rich repeat	238..260	CDD:275380	10/21 (48%)
		leucine-rich repeat	261..279	CDD:275380	10/17 (59%)
		CH	676..756	CDD:214479	13/89 (15%)
lrch4	XP_031754247.1	leucine-rich repeat	103..125	CDD:275380	8/21 (38%)
		LRR	119..>304	CDD:227223	87/185 (47%)
		leucine-rich repeat	126..148	CDD:275380	8/21 (38%)
		leucine-rich repeat	149..171	CDD:275380	11/21 (52%)
		leucine-rich repeat	172..187	CDD:275380	7/14 (50%)
		leucine-rich repeat	194..216	CDD:275380	11/22 (50%)
		leucine-rich repeat	217..239	CDD:275380	10/21 (48%)
		leucine-rich repeat	240..260	CDD:275380	10/19 (53%)
		leucine-rich repeat	262..284	CDD:275380	10/21 (48%)
		leucine-rich repeat	285..303	CDD:275380	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010