DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and Lrch2

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_038956102.1	Gene:	Lrch2 / 680591	RGDID:	1590569	Length:	798	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	274/835 - (32%)
Similarity:	392/835 - (46%)	Gaps:	190/835 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTS--------------------SALLSH 59
            |.|..:|:|.|.|..   |.|.|.|:|.|..|....:.:                    |..|..
  Rat    20 GSGGGSGAAGGGGGG---GGGGGGGAGAGGGGGCGGTVAVPIPVPTLFGQPFPNGPQWHSGSLQP 81

  Fly    60 SQLTRSLERILEEAHFSGELILTNRKLKDFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTFAFL 124
            ....|||:|.||||..||.|.|:.|||::||  |:.|.||||..||||||||.|:|.:|..||.|
  Rat    82 QHTVRSLDRALEEAGNSGILSLSGRKLREFP--GSGYDLTDTTQADLSRNRFTEIPSDVWLFAPL 144

  Fly   125 ETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRL 189
            |||.||||.|::|||::|.|..||||::..|.||:||:.:..|||:||:||||:|.|:|:|:|:|
  Rat   145 ETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKL 209

  Fly   190 DQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPLE 254
             :.|.:||.|.|::..||.::|:|.||:.|::|.|:|..||.||..|.|:.||.|.||:..:|:.
  Rat   210 -KDLMELDISCNEIQVLPQQMGKLHSLKELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVC 273

  Fly   255 IRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQA--TKDEKGSRSGGNYDGYTTLRRAP 317
            .|.:..|..:.|:||||..|||.:|::|.||:||:|..||  ..|:|..    :.|..:..:|.|
  Rat   274 YRKLHQLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPD----SLDLPSLNKRMP 334

  Fly   318 RHNSSGNVLEASTTGSTNN---QRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNSTAA 379
                     ....|.|..:   .:.|..|||..:.:| :||.|...|:...|.|
  Rat   335 ---------SQPLTDSMEDFYPNKNHGPDSGIGSDNG-EKRLSTTEPSDDDTIS----------- 378

  Fly   380 TLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSSNGSSPD-QDDDI 443
                     :|||....:...||.|.::|                        .|:.|| |.|..
  Rat   379 ---------LHSQVSESNREQTSRTDSLV------------------------TGTKPDSQKDQE 410

  Fly   444 MLDH-QERTVHHANGRSG-KGLGNIQTYKEYKEAL--KQQRNQEISVYKQKHPNANHSPNDDEDL 504
            :.|. ...|...|....| ..:|:..::.:.||..  |.|:|:|:. .::|.......|.:|:||
  Rat   411 VYDFIDPNTEEVAVPEQGDTHIGSFVSFLKGKEKCPEKSQKNEELG-NEKKVDKEQLLPEEDDDL 474

  Fly   505 SP--------------------SPPSISNGSSSNTLPK---------------SIMKQNSNQIGH 534
            ..                    .|.|.....|.....:               |:|:....|...
  Rat   475 KEVTDLRKIAAQLLKQEQKNRWRPLSYRTSFSDKLFQRTRAAGRKSRILNHSTSVMRNKLKQTVE 539

  Fly   535 NGNGNGSANGNGVDDVVIPKKPI---------QKVIPSRITEIKP--------ASTSDIRSANSS 582
            ......:..||.      |..|:         .:::..:..|.:|        ..:..||..
  Rat   540 CEKSVSADEGNS------PLSPLAWQPLENQKDQIVDQQWPESQPIIWQNEERRRSKQIRKE--- 595

  Fly   583 DCLGYVKPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVKTHRSVTWNH--- 644
                |.|.:|..||       |:|...:......:..:.:|||||.      ...||..::|
  Rat   596 ----YFKYKSTRKN-------SSGNENEEQESDNAHMSPQSPVSSE------DYDRSDGFSHGPF 643

  Fly   645 --------------DIPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDG 695
                          :..|....|||||:.:..|||.|.:.|||..:|:|||:.||.||.:||.||
  Rat   644 GLKPRSAFSRASRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDG 708

  Fly   696 VILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELIC 750
            |:||||||::|||||||||||||.|.||:||:|||||:|||:||:::||.:|.:|
  Rat   709 VVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLC 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	32/54 (59%)
		LRR_4	124..161	CDD:289563	21/36 (58%)
		leucine-rich repeat	124..146	CDD:275380	14/21 (67%)
		leucine-rich repeat	147..167	CDD:275380	9/19 (47%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..215	CDD:275380	9/21 (43%)
		leucine-rich repeat	216..237	CDD:275380	9/20 (45%)
		leucine-rich repeat	238..260	CDD:275380	8/21 (38%)
		leucine-rich repeat	261..279	CDD:275380	9/17 (53%)
		CH	676..756	CDD:214479	51/75 (68%)
Lrch2	XP_038956102.1	PRK15370	<82..>290	CDD:185268	106/210 (50%)
		leucine-rich repeat	100..120	CDD:275380	10/21 (48%)
		leucine-rich repeat	121..143	CDD:275380	13/21 (62%)
		leucine-rich repeat	144..166	CDD:275380	14/21 (67%)
		leucine-rich repeat	167..182	CDD:275380	8/14 (57%)
		leucine-rich repeat	189..211	CDD:275380	13/22 (59%)
		leucine-rich repeat	212..234	CDD:275380	9/21 (43%)
		leucine-rich repeat	235..255	CDD:275380	9/19 (47%)
		leucine-rich repeat	257..279	CDD:275380	8/21 (38%)
		leucine-rich repeat	280..298	CDD:275380	9/17 (53%)
		CH_LRCH2	676..786	CDD:409120	58/88 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5549
eggNOG	1	0.900	-	-		E2759_KOG0532
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1898
OMA	1	1.010	-	-		QHG46074
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm45704
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840