DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and Erbin

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	NP_001005868.1	Gene:	Erbin / 59079	MGIID:	1890169	Length:	1450	Species:	Mus musculus

Alignment Length:	1058	Identity:	214/1058 - (20%)
Similarity:	368/1058 - (34%)	Gaps:	322/1058 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SALLSHSQLTRSLERILE--EAHFSGELI------LTNRKLKDFPRTGTKYSLTDTVIADLSRNR 110
            |.||:.:||..: :..||  .|:| |.|.      |...:||..|:|..:  ||.....||..|.
Mouse   135 SQLLNLTQLYLN-DAFLEFLPANF-GRLTKLQILELRENQLKMLPKTMNR--LTQLERLDLGSNE 195

  Fly   111 FAELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLD-----------------------L 152
            |.|:||.:...:.|....:..|.:..||..:..|..|||||                       |
Mouse   196 FTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLL 260

  Fly   153 RSNQLSSLPREICFLP-LQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSL 216
            .||.|..||..|..|. :..|.:..|:|..|||.:|.| :::.:||.|:|::..||:.:|:|.::
Mouse   261 SSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGL-RSIEELDCSFNEIEALPSSIGQLTNM 324

  Fly   217 RSLSLRSNHLLYLPREL-TCLSLISLDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLC- 279
            |:.:...|:|..||.|: ...::..|.:..||:.:||.|:..|..|..:.|.:|.|.:.|.|..
Mouse   325 RTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389

  Fly   280 -------------MRGLVHVFKFLETQATKDEKGSRSGGNYDGYTTLRRAPRHNSSGNVLEASTT 331
                         .:.|:.:.|..:|:..|            ...|....|:...:.:|:..|..
Mouse   390 LQQLTAMWLSDNQSKPLIPLQKETDTETQK------------MVLTNYMFPQQPRTEDVMFISDN 442

  Fly   332 GSTN-----NQRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNSTAATLPRTLPSAVHS 391
            .|.|     .||:.:....:...:..|:|   :||.:           .......|...|..:
Mouse   443 ESFNPALWEEQRKQRAQVAFECDEDKDER---EAPPR-----------EGNLKRYPTPYPDEL-- 491

  Fly   392 QADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSSNGSSPDQDDDIMLDHQERTVHHAN 456
                  .::..:..|||.            :|....:|..| |....|.:|..:.::::.|..:.
Mouse   492 ------KNMVKTVQTIVH------------RLKDEETNEES-GRDLKQHEDQQVVNKDKCVKTSE 537

  Fly   457 GRSGKG--------LGNIQTYKEYKEALKQQRNQEISVYKQKHPNANHSPNDD------EDLSPS 507
            ..:.|.        :.::|...| .||.....|..::...:...|..|..|.|      |:||..
Mouse   538 STTTKSKLDEREKYMNSVQKMSE-PEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSD 601

  Fly   508 ---------PPSISNGSSSNTLPKSIMKQN------------SNQIGHNGNGNGSANGNGVDDVV 551
                     ||.|   .||...||.:...|            |:::.||.|.|.|...:
Mouse   602 EEMKMAEMRPPLI---ESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSS------ 657

  Fly   552 IPKKPIQKVIPSRITEIKPASTSDIRSANSSDCLGYVKPQSPMKNGTSKFNTSNGGGVQTTVGIV 616
                      |||:::....:|..  |.::|.|       ||:|
Mouse   658 ----------PSRMSDSVSLNTDS--SQDTSLC-------SPVK--------------------- 682

  Fly   617 SSTTIKSPVSSTTKLGTV-KTHRSVTWN----HDIPAEKLSFTMRREFDRQREETELMSQLRTII 676
                 ::||.|.:|:... :...|:..|    ::.|.||.....:::|.....:..:..|| .:|
Mouse   683 -----QTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQL-VLI 741

  Fly   677 ETRLKMTLPVDIASALT--DGVILCHL---------ANYVRP----RSVASIHVPSPGVNKLTMA 726
            |.        ||.|..|  |...|.|:         .|..:|    ||.....|...|...:...
Mouse   742 EK--------DIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPK 798

  Fly   727 RCRRNVDN-----FLEACRRI-GVDEELICSCEDVVPQIEPQQPQLPRADDDYDADVYVQD---- 781
            ....:::|     .||:..:: |:       |||..|.....:||...:..|.......:|
Mouse   799 NEAEHIENGAKFPNLESINKVNGL-------CEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQ 856

  Fly   782 ----DGSISRSNDSSHLQ---------CSDDCNSSSNHINRVPNAL---ALLRTVSALIAMDE-- 828
                .|::.:|:..::::         ..||.....:...::.:|:   .::|:.||.:..|:
Mouse   857 RSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPL 921

  Fly   829 --------------------------NPYHQQLHHHLQLQLEQQ--H-FEQEQFSEPTTCSQQQE 864
                                      ||....:.....:...|.  | :...|::...:.|...:
Mouse   922 QVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVK 986

  Fly   865 QMLLLQQQQQQLEHVLY-ENGLPRAENDDGVEDRDDDIGKRQQQLATVGQMLLKAKQKTYEKIKH 928
            ..|...:|..|::.|.: ...|||:|:                           |:..:|.|...
Mouse   987 DTLWHPKQNPQIDPVSFPPQRLPRSES---------------------------AENHSYAKHSA 1024

  Fly   929 NLLSAHGQHNFQGNNNNR 946
            |:       ||..:||.|
Mouse  1025 NM-------NFSNHNNVR 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	20/78 (26%)
		LRR_4	124..161	CDD:289563	14/59 (24%)
		leucine-rich repeat	124..146	CDD:275380	5/21 (24%)
		leucine-rich repeat	147..167	CDD:275380	12/42 (29%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..215	CDD:275380	8/21 (38%)
		leucine-rich repeat	216..237	CDD:275380	6/21 (29%)
		leucine-rich repeat	238..260	CDD:275380	7/21 (33%)
		leucine-rich repeat	261..279	CDD:275380	6/17 (35%)
		CH	676..756	CDD:214479	22/100 (22%)
Erbin	NP_001005868.1	leucine-rich repeat	24..47	CDD:275380
		LRR_RI	<48..209	CDD:238064	25/77 (32%)
		leucine-rich repeat	48..70	CDD:275380
		LRR	70..418	CDD:227223	81/287 (28%)
		leucine-rich repeat	71..93	CDD:275380
		leucine-rich repeat	94..116	CDD:275380
		leucine-rich repeat	117..139	CDD:275380	2/3 (67%)
		LRR_RI	<130..314	CDD:238064	55/183 (30%)
		leucine-rich repeat	140..162	CDD:275380	8/23 (35%)
		leucine-rich repeat	163..185	CDD:275380	6/23 (26%)
		leucine-rich repeat	186..208	CDD:275380	7/21 (33%)
		leucine-rich repeat	209..231	CDD:275380	5/21 (24%)
		leucine-rich repeat	278..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..323	CDD:275380	8/21 (38%)
		leucine-rich repeat	347..369	CDD:275380	7/21 (33%)
		LRR_4	368..411	CDD:289563	7/42 (17%)
		leucine-rich repeat	370..390	CDD:275380	6/19 (32%)
		PDZ_signaling	1359..1445	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910