DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrch and LRCH2

DIOPT Version :10

Sequence 1:NP_609834.2 Gene:Lrch / 35041 FlyBaseID:FBgn0032633 Length:1135 Species:Drosophila melanogaster
Sequence 2:NP_065922.3 Gene:LRCH2 / 57631 HGNCID:29292 Length:765 Species:Homo sapiens


Alignment Length:823 Identity:274/823 - (33%)
Similarity:391/823 - (47%) Gaps:186/823 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GVGSAAGSAIGSGSASLPGSGT--GSGSGIGHAGNTSSST---------------------SSAL 56
            |.|::.|...|.|.:| .|.||  |.|.|.|..|.....|                     :...
Human     7 GGGNSGGGGCGGGGSS-GGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLFGQPFPNGPPWNPGS 70

  Fly    57 LSHSQLTRSLERILEEAHFSGELILTNRKLKDFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTF 121
            |......|||:|.||||..||.|.|:.|||:|||  |:.|.||||..||||||||.|:|.:|..|
Human    71 LQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFP--GSGYDLTDTTQADLSRNRFTEIPSDVWLF 133

  Fly   122 AFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDEL 186
            |.||||.||||.|::|||::|.|..||||::..|.||:||:.:..|||:||:||||:|.|:|:|:
Human   134 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEI 198

  Fly   187 GRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASL 251
            |:| :.|.:||.|.|::..||.::|:|.|||.|::|.|:|..||.||..|.|:.||.|.||:..:
Human   199 GKL-KDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEI 262

  Fly   252 PLEIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQA--TKDEKGSRSGGNYDGYTTLR 314
            |:..|.:..|..:.|:||||..|||.:|::|.||:||:|..||  ..|:|..    :.|..:..:
Human   263 PVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPD----SLDLPSLSK 323

  Fly   315 RAPRHNSSGNVLEASTTGSTNN---QRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNS 376
            |.|         ....|.|..:   .:.|..|||..:.:| :||.|...|:...|.|        
Human   324 RMP---------SQPLTDSMEDFYPNKNHGPDSGIGSDNG-EKRLSTTEPSDDDTVS-------- 370

  Fly   377 TAATLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSSNGSSPDQD- 440
                        :|||....:...||...                    :|...|...|..||: 
Human   371 ------------LHSQVSESNREQTSRND--------------------SHIIGSKTDSQKDQEV 403

  Fly   441 --------DDIMLDHQERTVHHANGRSGKGLGNIQTYKEYKE--ALKQQRNQEISVYKQKHPNAN 495
                    :|:.:..|          ....:|:..::.:.||  :.|.::|:|:...|:......
Human   404 YDFVDPNTEDVAVPEQ----------GNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQL 458

  Fly   496 HSPNDDEDL---------------SPSPPSISNGSSSNTLPKSIMKQNSNQIGHNGNGNGSANGN 545
            .:..:|:||               ......|.|.|:      |:|:....|...      .....
Human   459 LAEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHST------SVMRNKPKQTVE------CEKSV 511

  Fly   546 GVDDVVIPKKPI-------QKVIPSRITEIK-PAS-----TSDIRSANSSDCLGYVKPQSPMKNG 597
            ..|:|..|..|:       ||   .:|.|.. |.|     .|:.|..:......|.|.:|..|:.
Human   512 SADEVNSPLSPLTWQPLENQK---DQIDEQPWPESHPIIWQSEERRRSKQIRKEYFKYKSMRKSS 573

  Fly   598 TSKFN---TSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVKTHRSVTWNH--------------- 644
            :...|   .|:...:.|          :|||||.      :..|:..::|               
Human   574 SGNENDEQDSDNANMST----------QSPVSSE------EYDRTDGFSHSPFGLKPRSAFSRSS 622

  Fly   645 --DIPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHLANYVRP 707
              :..|....|||||:.:..|||.|.:.|||..:|:|||:.||.||.:||.|||:||||||::||
Human   623 RQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRP 687

  Fly   708 RSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELIC 750
            |||||||||||.|.||:||:|||||:|||:||:::||.:|.:|
Human   688 RSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLC 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrchNP_609834.2 LRR <81..>286 CDD:443914 105/204 (51%)
leucine-rich repeat 124..146 CDD:275380 14/21 (67%)
leucine-rich repeat 147..167 CDD:275380 9/19 (47%)
leucine-rich repeat 169..192 CDD:275380 13/22 (59%)
leucine-rich repeat 193..215 CDD:275380 9/21 (43%)
leucine-rich repeat 216..237 CDD:275380 10/20 (50%)
leucine-rich repeat 238..260 CDD:275380 8/21 (38%)
leucine-rich repeat 261..279 CDD:275380 9/17 (53%)
CH_LRCH 667..755 CDD:409054 55/84 (65%)
CH_SF <1075..1099 CDD:469584
LRCH2NP_065922.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 13/32 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..76 1/20 (5%)
LRR 1 89..110 12/22 (55%)
leucine-rich repeat 92..112 CDD:275380 11/21 (52%)
LRR <108..>282 CDD:443914 89/174 (51%)
LRR 2 112..133 13/20 (65%)
leucine-rich repeat 113..135 CDD:275380 13/21 (62%)
LRR 3 135..156 13/20 (65%)
leucine-rich repeat 136..158 CDD:275380 14/21 (67%)
LRR 4 158..179 9/20 (45%)
leucine-rich repeat 159..174 CDD:275380 8/14 (57%)
LRR 5 180..201 13/20 (65%)
leucine-rich repeat 181..203 CDD:275380 13/22 (59%)
LRR 6 203..224 8/20 (40%)
leucine-rich repeat 204..226 CDD:275380 9/21 (43%)
LRR 7 226..248 11/21 (52%)
leucine-rich repeat 227..247 CDD:275380 10/19 (53%)
leucine-rich repeat 249..271 CDD:275380 8/21 (38%)
LRR 8 249..269 8/19 (42%)
LRR 9 271..292 10/20 (50%)
leucine-rich repeat 272..290 CDD:275380 9/17 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..401 24/134 (18%)
DUF5401 <434..539 CDD:375164 23/119 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 498..552 12/62 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..628 13/78 (17%)
CH_LRCH2 643..753 CDD:409120 58/88 (66%)
Blue background indicates that the domain is not in the aligned region.

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