DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and ERBIN

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_005248611.1	Gene:	ERBIN / 55914	HGNCID:	15842	Length:	1460	Species:	Homo sapiens

Alignment Length:	1065	Identity:	217/1065 - (20%)
Similarity:	378/1065 - (35%)	Gaps:	298/1065 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SALLSHSQLTRSLERILE--EAHFSGELI------LTNRKLKDFPRTGTKYSLTDTVIADLSRNR 110
            |.||:.:||..: :..||  .|:| |.|.      |...:||..|:|..:  ||.....||..|.
Human   135 SQLLNLTQLYLN-DAFLEFLPANF-GRLTKLQILELRENQLKMLPKTMNR--LTQLERLDLGSNE 195

  Fly   111 FAELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLD-----------------------L 152
            |.|:||.:...:.|:...:..|.:..||..:..|..|||||                       |
Human   196 FTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLL 260

  Fly   153 RSNQLSSLPREICFLP-LQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSL 216
            .||.|..||..|..|. :..|.:..|:|..|||.:|.| .::.:||.|:|::..||:.:|:|.:|
Human   261 SSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL-ISVEELDCSFNEVEALPSSIGQLTNL 324

  Fly   217 RSLSLRSNHLLYLPREL-TCLSLISLDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLCM 280
            |:.:...|:|..||.|: :..::..|.:.:||:.:||.|:..|..|..:.|.:|.|.:.|.|...
Human   325 RTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389

  Fly   281 RGLVHVFKFLETQA---------TKDEKGSRSGGNYDGYTTLRRAPRHNSSGNVLEASTTGSTN- 335
            ...:......:.|:         |..|.......||       ..|:...:.:|:..|...|.|
Human   390 LQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNY-------MFPQQPRTEDVMFISDNESFNP 447

  Fly   336 ----NQRRHQVDSGYNTSDGLDKRWSHDAPTKS------KTDSPLHCVSNSTAATLPRTLPSAVH 390
                .||:.:....:...:..|:|   :||.:.      .|..|      .....:.:|:.:.||
Human   448 SLWEEQRKQRAQVAFECDEDKDER---EAPPREGNLKRYPTPYP------DELKNMVKTVQTIVH 503

  Fly   391 -------------------SQADL---MDASLTSSTSTI---VDESLTLSPTASPCKLSYAHSNS 430
                               .|.|:   :....:.||:|:   |||           :..|...||
Human   504 RLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDE-----------REKYMIGNS 557

  Fly   431 SSNGSSPDQDDDIMLDHQERTVHHANGRSGKGLGNIQTYKE-YKEALKQQRNQEISVYKQKHPNA 494
            ....|.|:.:    :......| .||.::.:.|.:|..:.: ::|:.:...::|:.:.:.:.|..
Human   558 VQKISEPEAE----ISPGSLPV-TANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLI 617

  Fly   495 NHSPNDDEDLSPSPPSISNGSSSNTLPKSIMKQNSNQIGHNGNGNGSANGNGVDDVVIPKKPIQK 559
            ..|.|     .|...::||....:|.....:   |:::.||.|.|.|...:
Human   618 ETSIN-----QPKVVALSNNKKDDTKETDSL---SDEVTHNSNQNNSNCSS-------------- 660

  Fly   560 VIPSRITEIKPASTSDIRSANSSDCLGYVKPQSPMK------NGTSKFNTSNGGGVQTTVGIVSS 618
              |||:::....:|..  |.::|.|       ||:|      |...:....|...:.....|::|
Human   661 --PSRMSDSVSLNTDS--SQDTSLC-------SPVKQTHIDINSKIRQEDENFNSLLQNGDILNS 714

  Fly   619 TTIKSPVSSTTKLGTVKTHRSVTWN---HDIPAEKLSFTMRREFD--RQREETELMSQLRTIIET 678
            :|.:.          .|.|....:|   :|:..|:....:.:..|  ...::|..:..:...:..
Human   715 STEEK----------FKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNK 769

  Fly   679 RLKMTL--PVDIASALTDGVILC-------------HLAN---YVRPRSVASIHVPSPGVNKLTM 725
            .:....  |..:..:.|..::|.             ||.|   |....||..::    |.::.|.
Human   770 LITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVN----GHSEETS 830

  Fly   726 ARCRRNVDNFLEACRRIGVDEELICSCEDVVPQ---------------------------IEPQQ 763
            ....|...:..:....:|:.:    |.||:.||                           :....
Human   831 QSPNRTEPHDSDCSVDLGISK----STEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNG 891

  Fly   764 PQLPRADDDYDADVYVQDDGSISRSNDSS-----HLQCSDDCNSSSNHINRVPNALALLRTVSAL 823
            ||.|.......:.|   |..:|.||..::     .||.....:|||:          |:....|:
Human   892 PQQPSTTVKITSAV---DGKNIVRSKSATLLYDQPLQVFTGSSSSSD----------LISGTKAI 943

  Fly   824 IAMDENPYHQQLHHHL------QLQLEQQHFEQEQFSEPTTCSQQQEQMLLLQQQQQQLEHVLY- 881
            ...|.|  |.....::      ..|...|.:...|::...:.|...:..|...:|..|::|..:
Human   944 FKFDSN--HNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFP 1006

  Fly   882 ENGLPRAENDDGVEDRDDDIGKRQQQLATVGQMLLKAKQKTYEKIKHNLLSAHGQHNFQGNNNNR 946
            ...|||:|:                           .:.::|.|...|:       ||..:||.|
Human  1007 PQLLPRSES---------------------------TENQSYAKHSANM-------NFSNHNNVR 1037

  Fly   947 M-----LHTIVENEHDVAAAGPAGH 966
            .     ||         ...|||.|
Human  1038 ANTAYHLH---------QRLGPARH 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	20/78 (26%)
		LRR_4	124..161	CDD:289563	14/59 (24%)
		leucine-rich repeat	124..146	CDD:275380	5/21 (24%)
		leucine-rich repeat	147..167	CDD:275380	12/42 (29%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..215	CDD:275380	8/21 (38%)
		leucine-rich repeat	216..237	CDD:275380	7/21 (33%)
		leucine-rich repeat	238..260	CDD:275380	7/21 (33%)
		leucine-rich repeat	261..279	CDD:275380	6/17 (35%)
		CH	676..756	CDD:214479	16/97 (16%)
ERBIN	XP_005248611.1	leucine-rich repeat	24..47	CDD:275380
		LRR_8	46..104	CDD:290566
		LRR_RI	<48..209	CDD:238064	25/77 (32%)
		leucine-rich repeat	48..70	CDD:275380
		leucine-rich repeat	71..93	CDD:275380
		leucine-rich repeat	94..116	CDD:275380
		leucine-rich repeat	117..139	CDD:275380	2/3 (67%)
		LRR_RI	<130..314	CDD:238064	55/183 (30%)
		LRR_8	139..194	CDD:290566	17/58 (29%)
		leucine-rich repeat	140..162	CDD:275380	8/23 (35%)
		leucine-rich repeat	163..185	CDD:275380	6/23 (26%)
		leucine-rich repeat	186..208	CDD:275380	7/21 (33%)
		leucine-rich repeat	209..231	CDD:275380	5/21 (24%)
		LRR_8	230..288	CDD:290566	15/57 (26%)
		leucine-rich repeat	255..277	CDD:275380	8/21 (38%)
		leucine-rich repeat	278..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..323	CDD:275380	8/21 (38%)
		LRR_8	322..380	CDD:290566	17/57 (30%)
		leucine-rich repeat	347..369	CDD:275380	7/21 (33%)
		LRR_4	368..411	CDD:289563	7/42 (17%)
		leucine-rich repeat	370..390	CDD:275380	6/19 (32%)
		PDZ_signaling	1369..1455	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910