DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrch and Lrch1

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_006252373.1	Gene:	Lrch1 / 502020	RGDID:	1595678	Length:	744	Species:	Rattus norvegicus

Alignment Length:	764	Identity:	270/764 - (35%)
Similarity:	376/764 - (49%)	Gaps:	158/764 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HAGNTSSSTSSALLSHSQLTRSLERILEEAHFSGELILTNRKLKDFPRTGTK-YSLTDTVIADLS 107
            |.|:|.|:..:.     .|.|.|||.||||..||.|.|:.||||:||||... :.|:|||.||||
  Rat    30 HHGSTGSAGFNL-----PLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLS 89

  Fly   108 RNRFAELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVL 172
            :||..|:|.|:..|..||.|.||||.||.|||::..|..||:|:|..||||:||..:|.|||:||
  Rat    90 KNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTHLNLSRNQLSALPACLCGLPLKVL 154

  Fly   173 LVSNNRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLS 237
            :.|||:|.|||:|:|:|.| |.:||.|.|::..||.::|:|:|||.|::|.|:|..||.||..|.
  Rat   155 IASNNKLGSLPEEIGQLKQ-LMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLP 218

  Fly   238 LISLDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQA----TKDE 298
            |:..|.|.||:..:|:..|.|..|..|.||||||.||||.:|.:|.||:||:|..||    |.|.
  Rat   219 LVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADS 283

  Fly   299 KGSRSGGNYDGYTTLRRAPRHNSSGNVLEASTTGSTNNQRRHQVDSGYNTSDGLDKRWSHDAPTK 363
                        ..|....|.:|..:|.::          :...|||..:.:| |||.|...|:.
  Rat   284 ------------LYLHSIERPHSHQHVEDS----------KKDSDSGVGSDNG-DKRLSATEPSD 325

  Fly   364 SKTDSPLHCVSNSTAATLPRTLPSAVH----SQADLMDA-SLTSSTSTIVDESLTLSPTAS--PC 421
            ..|.| |:...::.|.....|...|.|    ::.|.... ||...:.:...|....:..|.  .|
  Rat   326 EDTVS-LNVPMSNIAEEDQTTKEDACHRLAPAEGDFQPTPSLLGDSGSSGQEREQFAGRADVLHC 389

  Fly   422 KL-SY-----------------AH-SNSSSNGSSPDQDDDIMLDHQERTVHHANGRSGKGLGNIQ 467
            :| :|                 || .......||.|||.||::                    |:
  Rat   390 ELMNYIKDQAEDCEELLRIEEDAHWQTEELLNSSKDQDLDIVM--------------------IE 434

  Fly   468 TYKEYKEALKQQRNQEISVYKQKHPNANHSPNDDEDLSPSPPSISNGSSSNTLPKSIMKQNSNQI 532
            ..:|.::.|:........:.::.  ..|..|....:....|.|..||...  |.:|..::..|.:
  Rat   435 QLREAEDLLQGPNGLTTDITERS--ILNLYPMCSAEALEFPDSSLNGQLQ--LERSPEREVQNDV 495

  Fly   533 GHNGNGNGSANGNGVDDVVIPKKPIQKVIPSRITEIKPASTSDIRSANSSDCLGYVKPQSPMKNG 597
            ....||:                   :..|:.|.|..|:.:.   :||.:...| :||:|
  Rat   496 TLQSNGS-------------------QCSPNEIREDSPSGSP---TANITAPFG-LKPRS----- 532

  Fly   598 TSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVKTHRSVTW---NHDIPAEKLS------- 652
                               ....|..|||..      |..::.||   ::.:|:|..|
  Rat   533 -------------------DPALILPPVSFN------KLTQAQTWDSSSYSVPSEGDSDNVFLRP 572

  Fly   653 ----------FTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHLANYVRP 707
                      ||:||:.::.|||.||:.|||..||.|||:||..|:.:||.|||:||||||:|||
  Rat   573 QRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRP 637

  Fly   708 RSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELICSCEDVV 756
            |||||||||||.|.||:||:|||||:|||||||::||.|..:||..|::
  Rat   638 RSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPYDIL 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	32/54 (59%)
		LRR_4	124..161	CDD:289563	21/36 (58%)
		leucine-rich repeat	124..146	CDD:275380	13/21 (62%)
		leucine-rich repeat	147..167	CDD:275380	11/19 (58%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..215	CDD:275380	9/21 (43%)
		leucine-rich repeat	216..237	CDD:275380	10/20 (50%)
		leucine-rich repeat	238..260	CDD:275380	8/21 (38%)
		leucine-rich repeat	261..279	CDD:275380	12/17 (71%)
		CH	676..756	CDD:214479	56/79 (71%)
Lrch1	XP_006252373.1	leucine-rich repeat	60..82	CDD:275380	11/21 (52%)
		leucine-rich repeat	83..105	CDD:275380	12/21 (57%)
		LRR_RI	<99..214	CDD:238064	60/115 (52%)
		LRR_8	105..161	CDD:290566	32/55 (58%)
		leucine-rich repeat	106..128	CDD:275380	13/21 (62%)
		leucine-rich repeat	129..144	CDD:275380	9/14 (64%)
		leucine-rich repeat	151..173	CDD:275380	13/21 (62%)
		LRR_8	172..252	CDD:290566	36/80 (45%)
		leucine-rich repeat	174..196	CDD:275380	9/21 (43%)
		leucine-rich repeat	197..217	CDD:275380	10/19 (53%)
		leucine-rich repeat	219..241	CDD:275380	8/21 (38%)
		leucine-rich repeat	242..261	CDD:275380	12/18 (67%)
		CH	596..685	CDD:214479	60/88 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5549
eggNOG	1	0.900	-	-		E2759_KOG0532
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1898
OMA	1	1.010	-	-		QHG46074
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm45704
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880