DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrch and LRCH4

DIOPT Version :10

Sequence 1:NP_609834.2 Gene:Lrch / 35041 FlyBaseID:FBgn0032633 Length:1135 Species:Drosophila melanogaster
Sequence 2:XP_047276334.1 Gene:LRCH4 / 4034 HGNCID:6691 Length:727 Species:Homo sapiens


Alignment Length:816 Identity:236/816 - (28%)
Similarity:340/816 - (41%) Gaps:204/816 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 SVAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHF 75
            :.||....|||....:.:.|:|||.       |..|.                ||.||.||||..
Human     2 AAAVAAPLAAGGEEAAATTSVPGSP-------GLPGR----------------RSAERALEEAVA 43

  Fly    76 SGELILTNRKLKDFPRTGTK-YSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPE 139
            :|.|.|:||:||.|||...: |.|:|...||||||||.|:||.......||.|.||||.:|.:..
Human    44 TGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNP 108

  Fly   140 SVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLA 204
            ::..|::||||:|..||||.||..||.|||:||:||||:|.:||.::|.|. :|..||.|.|:|.
Human   109 ALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLG-SLRQLDVSSNELQ 172

  Fly   205 NLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPL---EIRHMSTLVELQL 266
            :||:.|..|.|||.|::|.|.|..||.||..|.|:.||.|.|:::.:|:   .:||:..::   |
Human   173 SLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVIL---L 234

  Fly   267 ENNPLTSPPASLCMRGLVHVFKFLETQATKDEKGSRSGGNYDGYTTLRRAPRHNSSGNVLEASTT 331
            ::|||.||||                     ::....|..:..:..|  .||         .|..
Human   235 DSNPLQSPPA---------------------QRPGSVGRPWGTWPLL--GPR---------VSVP 267

  Fly   332 GSTNNQRRHQ------------------------VDSGYNTSDGLDKRWSHDAPTKSKTDSPLHC 372
            |......:||                        :|||:::.|...||||.:..|...::.....
Human   268 GGWGAVVQHQADQIRLAGPSPAEDLFPGHRYDGGLDSGFHSVDSGSKRWSGNESTDEFSELSFRI 332

  Fly   373 VSNSTAATLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSSNGSSP 437
            ...:.....||.......:..|.:......|.....||.........|.:||....:.....||.
Human   333 SELAREPRGPRERKEDGSADGDPVQIDFIDSHVPGEDEERGTVEEQRPPELSPGAGDRERAPSSR 397

  Fly   438 DQDDDIMLDHQERTVHHANGRSGKGLGNIQTYKEYKEALKQQRNQEISVYKQKHPNANHSPNDDE 502
            .::              ..|...:....:|.::|      ::|.|      |:...|..:|..|.
Human   398 REE--------------PAGEERRRPDTLQLWQE------RERRQ------QQQSGAWGAPRKDS 436

  Fly   503 DLSPSPPSISNGSSSNTLPKSIMKQNSNQIGHNGNGNGSANGNGV---DDVVIPKKPIQKVIPSR 564
            .|.|...::..|:::          .|.|..|||:...||:..|.   .....|....|:.:|..
Human   437 LLKPGLRAVVGGAAA----------VSTQAMHNGSPKSSASQAGAAAGQGAPAPAPASQEPLPIA 491

  Fly   565 ITEIKPASTSDIRSANSSDCLGYV-KPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSST 628
            .....||...          ||.: :|.|.:...:|:    :|.|                    
Human   492 GPATAPAPRP----------LGSIQRPNSFLFRSSSQ----SGSG-------------------- 522

  Fly   629 TKLGTVKTHRSVTWNHDIPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALT 693
                              |:...|....|.:.:..:|.:||:|||.::|:||:..||.|:|.||.
Human   523 ------------------PSSPDSVLRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAEALA 569

  Fly   694 DGVILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDE------------ 746
            .|||||.|||.:|||||..||||||.|.||:..:.|:||::||||||::||.|            
Human   570 SGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEVWGLLSKEWWHA 634

  Fly   747 --ELICS-----------CEDVVPQIEPQQPQLPRA 769
              ...|.           |..:..|..|..|.:|.|
Human   635 GLSRACGMDGGLPFAADVCSQMKAQAAPALPSMPPA 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrchNP_609834.2 LRR <81..>286 CDD:443914 96/208 (46%)
leucine-rich repeat 124..146 CDD:275380 9/21 (43%)
leucine-rich repeat 147..167 CDD:275380 13/19 (68%)
leucine-rich repeat 169..192 CDD:275380 12/22 (55%)
leucine-rich repeat 193..215 CDD:275380 10/21 (48%)
leucine-rich repeat 216..237 CDD:275380 10/20 (50%)
leucine-rich repeat 238..260 CDD:275380 8/24 (33%)
leucine-rich repeat 261..279 CDD:275380 8/17 (47%)
CH_LRCH 667..755 CDD:409054 50/112 (45%)
CH_SF <1075..1099 CDD:469584
LRCH4XP_047276334.1 leucine-rich repeat 46..69 CDD:275380 11/22 (50%)
LRR <65..>241 CDD:443914 84/179 (47%)
leucine-rich repeat 70..92 CDD:275380 11/21 (52%)
leucine-rich repeat 93..115 CDD:275380 9/21 (43%)
leucine-rich repeat 116..131 CDD:275380 10/14 (71%)
leucine-rich repeat 138..160 CDD:275380 12/22 (55%)
leucine-rich repeat 161..183 CDD:275380 10/21 (48%)
leucine-rich repeat 184..204 CDD:275380 10/19 (53%)
leucine-rich repeat 206..228 CDD:275380 6/21 (29%)
CH_SF 540..>623 CDD:469584 48/82 (59%)
Blue background indicates that the domain is not in the aligned region.

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