DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrch and LRCH4

DIOPT Version :9

Sequence 1:NP_609834.2 Gene:Lrch / 35041 FlyBaseID:FBgn0032633 Length:1135 Species:Drosophila melanogaster
Sequence 2:NP_002310.2 Gene:LRCH4 / 4034 HGNCID:6691 Length:683 Species:Homo sapiens


Alignment Length:761 Identity:238/761 - (31%)
Similarity:349/761 - (45%) Gaps:149/761 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 SVAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHF 75
            :.||....|||....:.:.|:|||.       |..|.                ||.||.||||..
Human     2 AAAVAAPLAAGGEEAAATTSVPGSP-------GLPGR----------------RSAERALEEAVA 43

  Fly    76 SGELILTNRKLKDFPRTGTK-YSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPE 139
            :|.|.|:||:||.|||...: |.|:|...||||||||.|:||.......||.|.||||.:|.:..
Human    44 TGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNP 108

  Fly   140 SVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLA 204
            ::..|::||||:|..||||.||..||.|||:||:||||:|.:||.::|.|. :|..||.|.|:|.
Human   109 ALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLG-SLRQLDVSSNELQ 172

  Fly   205 NLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPL---EIRHMSTLVELQL 266
            :||:.|..|.|||.|::|.|.|..||.||..|.|:.||.|.|:::.:|:   .:||:..::   |
Human   173 SLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVIL---L 234

  Fly   267 ENNPLTSPPASLCMRGLVHVFKFLETQATKDEKGSRSGG-------NYDGYTTLRRAPRHNSSGN 324
            ::|||.||||.:|::|.:|:||:|.|:|  .::||..|.       ::.........|.|...|.
Human   235 DSNPLQSPPAQVCLKGKLHIFKYLSTEA--GQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGG 297

  Fly   325 VLEASTTGSTNNQRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNSTAATLPRTLPSAV 389
                             :|||:::.|...||||.:..|...::........:.....||......
Human   298 -----------------LDSGFHSVDSGSKRWSGNESTDEFSELSFRISELAREPRGPRERKEDG 345

  Fly   390 HSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSSNGSSPDQDDDIMLDHQERTVHH 454
            .:..|.:......|.....||.........|.:||....:.....||..::              
Human   346 SADGDPVQIDFIDSHVPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREE-------------- 396

  Fly   455 ANGRSGKGLGNIQTYKEYKEALKQQRNQEISVYKQKHPNANHSPNDDEDLSPSPPSISNGSSSNT 519
            ..|...:....:|.::|      ::|.|      |:...|..:|..|..|.|...::..|:::  
Human   397 PAGEERRRPDTLQLWQE------RERRQ------QQQSGAWGAPRKDSLLKPGLRAVVGGAAA-- 447

  Fly   520 LPKSIMKQNSNQIGHNGNGNGSANGNGV---DDVVIPKKPIQKVIPSRITEIKPASTSDIRSANS 581
                    .|.|..|||:...||:..|.   .....|....|:.:|.......||...       
Human   448 --------VSTQAMHNGSPKSSASQAGAAAGQGAPAPAPASQEPLPIAGPATAPAPRP------- 497

  Fly   582 SDCLGYV-KPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVKTHRSVTWNHD 645
               ||.: :|.|.:...:|:    :|.|                                     
Human   498 ---LGSIQRPNSFLFRSSSQ----SGSG------------------------------------- 518

  Fly   646 IPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHLANYVRPRSV 710
             |:...|....|.:.:..:|.:||:|||.::|:||:..||.|:|.||..|||||.|||.:|||||
Human   519 -PSSPDSVLRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSV 582

  Fly   711 ASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELICSCEDVV 756
            ..||||||.|.||:..:.|:||::||||||::||.|..:||..|::
Human   583 PFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEADLCSPSDLL 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrchNP_609834.2 LRR_8 124..179 CDD:290566 31/54 (57%)
LRR_4 124..161 CDD:289563 18/36 (50%)
leucine-rich repeat 124..146 CDD:275380 9/21 (43%)
leucine-rich repeat 147..167 CDD:275380 13/19 (68%)
leucine-rich repeat 169..192 CDD:275380 12/22 (55%)
leucine-rich repeat 193..215 CDD:275380 10/21 (48%)
leucine-rich repeat 216..237 CDD:275380 10/20 (50%)
leucine-rich repeat 238..260 CDD:275380 8/24 (33%)
leucine-rich repeat 261..279 CDD:275380 8/17 (47%)
CH 676..756 CDD:214479 46/79 (58%)
LRCH4NP_002310.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 12/54 (22%)
LRR 1 43..64 10/20 (50%)
leucine-rich repeat 46..69 CDD:275380 11/22 (50%)
LRR 2 69..90 12/20 (60%)
leucine-rich repeat 70..92 CDD:275380 11/21 (52%)
LRR_8 92..148 CDD:290566 31/55 (56%)
LRR_4 92..131 CDD:289563 19/38 (50%)
LRR 3 92..114 8/21 (38%)
leucine-rich repeat 93..115 CDD:275380 9/21 (43%)
LRR_RI <103..>245 CDD:238064 66/145 (46%)
LRR 4 115..136 13/20 (65%)
leucine-rich repeat 116..131 CDD:275380 10/14 (71%)
LRR 5 137..158 12/20 (60%)
LRR_8 138..194 CDD:290566 28/56 (50%)
leucine-rich repeat 138..160 CDD:275380 12/22 (55%)
LRR 6 160..182 9/21 (43%)
leucine-rich repeat 161..183 CDD:275380 10/21 (48%)
LRR_8 182..239 CDD:290566 22/59 (37%)
LRR 7 183..205 11/21 (52%)
leucine-rich repeat 184..204 CDD:275380 10/19 (53%)
leucine-rich repeat 206..228 CDD:275380 6/21 (29%)
LRR 8 206..226 6/19 (32%)
LRR 9 228..249 10/23 (43%)
leucine-rich repeat 229..247 CDD:275380 8/20 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 268..292 2/23 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 326..436 21/135 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..539 24/141 (17%)
CH 537..627 CDD:278723 51/89 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0532
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46074
OrthoDB 1 1.010 - - D186976at33208
OrthoFinder 1 1.000 - - FOG0000912
OrthoInspector 1 1.000 - - otm41580
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X454
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.790

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