DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and Lrch1

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_006519217.3	Gene:	Lrch1 / 380916	MGIID:	2443390	Length:	877	Species:	Mus musculus

Alignment Length:	867	Identity:	284/867 - (32%)
Similarity:	389/867 - (44%)	Gaps:	243/867 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HAGNTSSSTSSALLSHSQLTRSLERILEEAHFSGELILTNRKLKDFPR-TGTKYSLTDTVIADLS 107
            |.|.|..:..:.     .|.|.|||.||||..||.|.|:.||||:||| |...:.|:|||.||||
Mouse   137 HHGGTGGTGFNL-----PLNRGLERALEEAANSGGLNLSARKLKEFPRTTAPGHDLSDTVRADLS 196

  Fly   108 RNRFAELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVL 172
            :||..|:|.|:..|..||.|.||||.||.|||::..|..||:|:|..||||:||..:|.|||:||
Mouse   197 KNRLVEVPMELCQFVSLEILNLYHNCIRVIPEAIVNLQMLTHLNLSRNQLSALPACLCGLPLKVL 261

  Fly   173 LVSNNRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLS 237
            :.|||:|.|||:|:|:|.| |.:||.|.|::..||.::|:|:|||.|::|.|:|..||.||..|.
Mouse   262 IASNNKLGSLPEEIGQLKQ-LMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLP 325

  Fly   238 LISLDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQATKDEKGSR 302
            |:..|.|.||:..:|:..|.|..|..|.||||||.||||.:|.:|.||:||:|..||.:.:   .
Mouse   326 LVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIK---T 387

  Fly   303 SGGNYDGYTTLRRAPRHNSSGNVLEASTTGSTNNQRRHQVDSGYNTSDGLDKRWSHDAPTKSKTD 367
            |...|  ..|:.|...|..    :|.|...|         |||..:.:| |||.|...|:...|
Mouse   388 SDSLY--LPTIERPHLHQH----VEDSKKDS---------DSGVGSDNG-DKRLSATEPSDEDT- 435

  Fly   368 SPLHCVSNSTAATLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSS 432
                                          .||.:..|.||:|..|:...|       .|..:.:
Mouse   436 ------------------------------VSLNAPMSNIVEEDQTIKEDA-------CHRLTPT 463

  Fly   433 NGSSPDQ-----DDDIMLDHQERTVHHANGRSGKGLGNIQTYKEYKEAL---------------- 476
            .|....:     |..|....:|:....|:.|....:..|:...|..|.|
Mouse   464 KGEFQPKPSILGDSGISGQEREQLAGRADARHSGLMNYIKDQAEDCEELLRIEEDAHWHMEELLN 528

  Fly   477 -KQQRNQEISVYKQ-------KHPNA-----------NHSPNDDEDLSPSP-PSISNGSSSNTLP 521
             .:.|..:|::.:|       :.||.           |..|.|..:.|..| ||::......|.|
Mouse   529 SSKDRELDIAMIEQLREAELLQDPNGLSADIIERSILNLFPMDSGEASEFPDPSLNGQLQLETSP 593

  Fly   522 KSIMKQNSNQIGHNGNGNGSANGNGVDDVVIPKKPIQKVIPSRITEIKPASTSDIRSANSSDCLG 586
            ...: ||...:..||:                     :..|:.|.|..|:
Mouse   594 DREV-QNDLMLQSNGS---------------------QYSPNEIRENSPS--------------- 621

  Fly   587 YVKPQSPMKNGTSKFNTSNGGG------VQTTVGIVSS------------TTIKSPVSSTTKLGT 633
                .||..|.|:.|......|      ||.::...||            ..|..|:|..|
Mouse   622 ----VSPTANITAPFGLKPRSGSWCPEEVQGSLQAESSPRRPQLLSRHDPALILPPISFNT---- 678

  Fly   634 VKTHRSVTW---NHDIPAEKLS-----------------FTMRREFDRQREETELMSQLRTIIET 678
              ..::.||   ::.:|:|..|                 ||:||:.::.|||.||:.|||..||.
Mouse   679 --LTQAQTWDNSSYSVPSEGNSDNVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEM 741

  Fly   679 RLKMTLPVDIASALTDGVILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIG 743
            |||:||..|:.:||.|||:||||||:||||||||||||||.|.||:||:|||||:|||||||::|
Mouse   742 RLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLG 806

  Fly   744 VDEELICSCEDVVPQIEPQQPQLPRADDDYDADVYVQDDGSISRSNDSSHLQCSDDCNSSSNHIN 808
            |.|..:||..|::        ||                       |..|::
Mouse   807 VPEADLCSPYDIL--------QL-----------------------DFRHIR------------- 827

  Fly   809 RVPNALALLRTVSALIAMDENP 830
                     :||..|:|:.|.|
Mouse   828 ---------KTVDTLLALGEKP 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	32/54 (59%)
		LRR_4	124..161	CDD:289563	21/36 (58%)
		leucine-rich repeat	124..146	CDD:275380	13/21 (62%)
		leucine-rich repeat	147..167	CDD:275380	11/19 (58%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..215	CDD:275380	9/21 (43%)
		leucine-rich repeat	216..237	CDD:275380	10/20 (50%)
		leucine-rich repeat	238..260	CDD:275380	8/21 (38%)
		leucine-rich repeat	261..279	CDD:275380	12/17 (71%)
		CH	676..756	CDD:214479	56/79 (71%)
Lrch1	XP_006519217.3	PRK15370	<162..>365	CDD:185268	106/203 (52%)
		leucine-rich repeat	167..189	CDD:275380	11/21 (52%)
		leucine-rich repeat	190..212	CDD:275380	12/21 (57%)
		leucine-rich repeat	213..235	CDD:275380	13/21 (62%)
		leucine-rich repeat	236..251	CDD:275380	9/14 (64%)
		leucine-rich repeat	258..280	CDD:275380	13/21 (62%)
		leucine-rich repeat	281..303	CDD:275380	9/21 (43%)
		leucine-rich repeat	304..324	CDD:275380	10/19 (53%)
		leucine-rich repeat	326..348	CDD:275380	8/21 (38%)
		leucine-rich repeat	349..368	CDD:275380	12/18 (67%)
		leucine-rich repeat	376..387	CDD:275378	4/13 (31%)
		CH	729..818	CDD:214479	60/88 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5676
eggNOG	1	0.900	-	-		E2759_KOG0532
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46074
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm43627
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3681
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820