DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and Lrch4

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_038945505.1	Gene:	Lrch4 / 360779	RGDID:	1306145	Length:	695	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	253/800 - (31%)
Similarity:	352/800 - (44%)	Gaps:	204/800 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAATVYQRLHSVAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRS 65
            |||.|...|   |.|...||.|....||..||||                             ||
  Rat     1 MAAAVAGPL---AAGGEEAAASVSVPGSPGLPGS-----------------------------RS 33

  Fly    66 LERILEEAHFSGELILTNRKLKDFPRTGTK-YSLTDTVIA---------DLSRNRFAELPEEVTT 120
            .||.||||..:|.|.|:||:||.|||...: |.|:|...|         |||||||.|:||....
  Rat    34 AERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQAAPSGPLLSLDLSRNRFPEVPEAACQ 98

  Fly   121 FAFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDE 185
            ...||.|.||||.:|.:..::..|::||||:|..|||||||..||.|||:||::|||:|.:||.:
  Rat    99 LVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSSLPPYICQLPLRVLIISNNKLGALPPD 163

  Fly   186 LGRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIAS 250
            :..|. :|..||.|.|:|.:||..|..|||||.|::|.|.|..||.||..|.|:.||.|.|:::.
  Rat   164 ISTLG-SLRQLDVSSNELQSLPVELCSLRSLRDLNVRRNQLSTLPDELGDLPLVRLDFSCNRVSR 227

  Fly   251 LPL---EIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQATK------DEKGSR---- 302
            :|:   .:||:..::   |::|||.||||.:|::|.:|:||:|..:|.:      |...||
  Rat   228 IPVSFCRLRHLQVIL---LDSNPLQSPPAQICLKGKLHIFKYLTMEAGRRGAALGDLVPSRPPSF 289

  Fly   303 ---------SGGNYDGYTTLRRAPRHNSSGNVLEASTTGSTNNQRRHQVDSGYNTSDGLDKRWSH 358
                     .|..|||                               .:|||:::.|...||||.
  Rat   290 SPCPAEDLFPGRRYDG-------------------------------GLDSGFHSVDSGSKRWSG 323

  Fly   359 DAPTKSKTDSPLHCVSNSTAATLPR--TLPSAVHS------QADLMDASLTSSTSTIVDESLTLS 415
            :..|...::.....   |..|..||  ..|....|      |.|.:|:.:.........|..|..
  Rat   324 NESTDDFSELSFRI---SELAREPRGPRQPREDGSGDGDLEQIDFIDSHVPGDDEQSAAEVRTQE 385

  Fly   416 PTASPCKLSYAHSN----SSSNGSSPDQDDDIMLDHQERTVHHANGRSGKGLGNIQTYKEYKEAL 476
            |.  |.:||.|..:    |||....|..::....|    |:|              .::|.:..|
  Rat   386 PL--PSELSLAAGDMERPSSSRREEPAGEERRRPD----TLH--------------LWQERERRL 430

  Fly   477 KQQRNQEISVYKQKHPNANHSPNDDEDLSPSPPSISNGSSSNTLPKSIMKQNSNQIGHNGNGNGS 541
            :||........|...|............:||..:..||.     |||    ::.|:|.:|.....
  Rat   431 QQQSGAWGPSKKDSIPKRGIRATGAGASAPSTQTACNGP-----PKS----SAAQLGVSGEQGAP 486

  Fly   542 ANGNGVDDVVIPKKPIQKVIPSRITEIKPASTSDIRSANSSDCLGYVKPQSPMKNGTSKFNTSNG 606
            ...:...|.:....|:...:|..:..|:..::...||::.|              |:|
  Rat   487 TLPSTSQDPLPVSGPVTAPVPRPLGSIQRPNSFLFRSSSQS--------------GSS------- 530

  Fly   607 GGVQTTVGIVSSTTIKSPVSSTTKLGTVKTHRSVTWNHDIPAEKLSFTMRREFDRQREETELMSQ 671
                                                    |:...|....|.|.:..||.||:||
  Rat   531 ----------------------------------------PSSPESVLRPRPFPQILEEKELISQ 555

  Fly   672 LRTIIETRLKMTLPVDIASALTDGVILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFL 736
            ||.|:|:||:..||.|:|.||.:|||||.|||.:|||||..||||||.|.||:..:.|:||:|||
  Rat   556 LRQILESRLQQPLPEDLAEALANGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKSRKNVENFL 620

  Fly   737 EACRRIGVDEELICSCEDVV 756
            ||||::||.|..:||..|::
  Rat   621 EACRKMGVPEADLCSPSDLL 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	31/54 (57%)
		LRR_4	124..161	CDD:289563	19/36 (53%)
		leucine-rich repeat	124..146	CDD:275380	9/21 (43%)
		leucine-rich repeat	147..167	CDD:275380	14/19 (74%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..215	CDD:275380	10/21 (48%)
		leucine-rich repeat	216..237	CDD:275380	10/20 (50%)
		leucine-rich repeat	238..260	CDD:275380	8/24 (33%)
		leucine-rich repeat	261..279	CDD:275380	8/17 (47%)
		CH	676..756	CDD:214479	47/79 (59%)
Lrch4	XP_038945505.1	LRR	25..264	CDD:227223	114/271 (42%)
		leucine-rich repeat	46..72	CDD:275380	12/25 (48%)
		leucine-rich repeat	79..101	CDD:275380	10/21 (48%)
		leucine-rich repeat	102..124	CDD:275380	9/21 (43%)
		leucine-rich repeat	125..144	CDD:275380	13/18 (72%)
		leucine-rich repeat	147..169	CDD:275380	10/22 (45%)
		leucine-rich repeat	170..192	CDD:275380	10/21 (48%)
		leucine-rich repeat	193..213	CDD:275380	10/19 (53%)
		leucine-rich repeat	215..237	CDD:275380	6/21 (29%)
		PHA03247	<280..507	CDD:223021	57/289 (20%)
		CH_LRCH4	548..654	CDD:409122	56/92 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9567
eggNOG	1	0.900	-	-		E2759_KOG0532
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1898
OMA	1	1.010	-	-		QHG46074
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm45704
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.840