DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and Lrch3

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_038944252.1	Gene:	Lrch3 / 303883	RGDID:	1306200	Length:	791	Species:	Rattus norvegicus

Alignment Length:	834	Identity:	283/834 - (33%)
Similarity:	397/834 - (47%)	Gaps:	195/834 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHFS 76
            |||...:.....:||| .:|.|:..|...|:| .|:.|              ||::|.||||..:
  Rat     7 VAVVAAAEYSGPVGSG-GNLSGANCGPSPGLG-PGSWS--------------RSVDRALEEAAVT 55

  Fly    77 GELILTNRKLKDFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPESV 141
            |.|.|:.|||::|||....:.||||..|||||||.:|:|.|...|..||:|.||.|.||.|||:|
  Rat    56 GVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPMETCHFVSLESLNLYQNCIRYIPEAV 120

  Fly   142 KQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLANL 206
            ..|.:||:|::..||||:||..:|.|||:||:.|||:|.|||:|:|:| :.||:||.|.|::..:
  Rat   121 LNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGQL-RHLTELDVSCNEIQTV 184

  Fly   207 PARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPLEIRHMSTLVELQLENNPL 271
            |:::|.|.:||..::|.||||.||.||..:.||.||.|.|||..:|:..|::..|..:.|:||||
  Rat   185 PSQIGNLEALRDFNVRRNHLLRLPEELAEVPLIRLDFSCNKITVIPVCYRNLRHLQVITLDNNPL 249

  Fly   272 TSPPASLCMRGLVHVFKFLETQATKDEKGSRSGGNYDGYTTLRRAP-------RHNSSGNVLEAS 329
            .||||.:|::|.:|:||:|..||.|                  .||       |....|:..|..
  Rat   250 QSPPAQICIKGKIHIFKYLNIQACK------------------IAPDLPDYERRPLGFGSCHEEL 296

  Fly   330 TTGSTNNQRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNSTAATLPR----------- 383
            .:|....    .:|||:|:.|..|||||.:.||...:|.||.....:....|.|
  Rat   297 YSGRPYG----ALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRSSV 357

  Fly   384 --TLPSAVH--SQADLMDASLTS------------STSTIVDESLT------LSPTASPCK---- 422
              |.....|  .|.|.:|:..|.            .||::..:.|.      :|...||.|
  Rat   358 VVTNGGVDHDLDQIDYIDSCTTEEEENDVKRPKSLDTSSLSSQFLAYIEQRRISHEGSPVKPIAV 422

  Fly   423 ---------LSYAHSN-------------SSSNGSSPDQDDDIMLDHQ--ERTVHHANGRSGKGL 463
                     ..|:|.|             .|.|..|   ..|:.| ||  |::|..|  |....|
  Rat   423 RDFQKTEDMKRYSHQNRVPVEPSLVLSVPPSHNQLS---HSDLEL-HQRGEQSVERA--RREAQL 481

  Fly   464 GNIQTYKEYKEALKQ-QRNQEISVYKQK---HPNANHSPNDDEDLSPSPPSISNGSSSNTLPKSI 524
            ..:| |:..|...|| ||:..:...|.|   :|.....|.:.|  .|.|...|..:..:.|..|:
  Rat   482 AALQ-YEGEKIRTKQIQRDAGLDFVKHKVSQNPQKQQPPGNGE--CPFPSRRSQHTDDSALLVSL 543

  Fly   525 MKQNSNQIGHNGNGNGSANGNGVDDV-VIPKKPIQKVIPSRITEIKPASTSDIRS-------ANS 581
                                :|:|.| .:..:|..    |..|.:|.....|:.|       |..
  Rat   544 --------------------SGLDGVSCVATRPHS----SAFTPLKSNDRVDVTSSFPMTDTARH 584

  Fly   582 SDCLGY---------VKPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVKTH 637
            |....:         .:|:|.:...|.:...|.|..              ||:.|:.
  Rat   585 SPAYSFPAATQRNQPQRPESFLFRATVRAEASKGRA--------------SPLLSSA-------- 627

  Fly   638 RSVTWNHDIPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHLA 702
                     ||...:.::.|:   :.||..|:.|||..||.|||::||.|:.:||||||:|||||
  Rat   628 ---------PATDAADSIARQ---REEELRLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLA 680

  Fly   703 NYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELICSCEDVV 756
            |:||||||.|||||||.|.|||||:|||||:|||:|||:|||.::.:||..|::
  Rat   681 NHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQDSLCSPSDIL 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	31/54 (57%)
		LRR_4	124..161	CDD:289563	20/36 (56%)
		leucine-rich repeat	124..146	CDD:275380	13/21 (62%)
		leucine-rich repeat	147..167	CDD:275380	10/19 (53%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..215	CDD:275380	9/21 (43%)
		leucine-rich repeat	216..237	CDD:275380	11/20 (55%)
		leucine-rich repeat	238..260	CDD:275380	10/21 (48%)
		leucine-rich repeat	261..279	CDD:275380	10/17 (59%)
		CH	676..756	CDD:214479	56/79 (71%)
Lrch3	XP_038944252.1	leucine-rich repeat	57..79	CDD:275380	9/21 (43%)
		LRR	<73..>281	CDD:227223	104/226 (46%)
		leucine-rich repeat	80..102	CDD:275380	12/21 (57%)
		leucine-rich repeat	103..125	CDD:275380	13/21 (62%)
		leucine-rich repeat	126..141	CDD:275380	8/14 (57%)
		leucine-rich repeat	148..170	CDD:275380	13/22 (59%)
		leucine-rich repeat	171..193	CDD:275380	9/21 (43%)
		leucine-rich repeat	194..214	CDD:275380	11/19 (58%)
		leucine-rich repeat	216..238	CDD:275380	10/21 (48%)
		leucine-rich repeat	239..257	CDD:275380	10/17 (59%)
		CH_SF	642..751	CDD:412120	62/93 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353942
Domainoid	1	1.000	121	1.000	Domainoid score	I5549
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1898
OMA	1	1.010	-	-		QHG46074
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm45704
orthoMCL	1	0.900	-	-		OOG6_107405
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.810