Protein Alignment Lrch and Lrch4

DIOPT Version :10

• Sequence 1: NP_609834.2
• Gene: Lrch / 35041
• FlyBaseID: FBgn0032633
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_666276.1
• Gene: Lrch4 / 231798
• MGIID: 1917193
• Length: 680
• Species: Mus musculus
• Alignment Length: 786
• Identity: 244/786 - (31%)
• Similarity: 345/786 - (43%)
• Gaps: 202/786 - (25%)

  Fly    11 SVAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHF 75
            :.||....|||....:.|.|||||....||                       ||.||.||||..
Mouse     2 AAAVAGPLAAGGEEAAASVSLPGSPGLPGS-----------------------RSAERALEEAVA 43

  Fly    76 SGELILTNRKLKDFPRTGTK-YSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPE 139
            :|.|.|:||:||.|||...: |.|:|...||||||||.|:||.......||.|.||||.::.:..
Mouse    44 TGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLKCLNP 108

  Fly   140 SVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLA 204
            ::..|::||||:|..|||||||..||.|||:||::|||:|.:||.::..|. :|..||.|.|:|.
Mouse   109 ALGNLTALTYLNLSRNQLSSLPPYICQLPLRVLIISNNKLGALPPDISTLG-SLRQLDVSSNELQ 172

  Fly   205 NLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPL---EIRHMSTLVELQL 266
            :||..|..|||||.|::|.|.|..||.||..|.|:.||.|.|:|:.:|:   .:||:..::   |
Mouse   173 SLPVELCSLRSLRDLNVRRNQLSTLPDELGDLPLVRLDFSCNRISRIPVSFCRLRHLQVVL---L 234

  Fly   267 ENNPLTSPPASLCMRGLVHVFKFLETQATK------DEKGSR-------------SGGNYDGYTT 312
            ::|||.||||.:|::|.:|:||:|..:|.:      |...||             .|..|||
Mouse   235 DSNPLQSPPAQICLKGKLHIFKYLTMEAGRRGAALGDLVPSRPPSFSPCPAEDLFPGRRYDG--- 296

  Fly   313 LRRAPRHNSSGNVLEASTTGSTNNQRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNST 377
                                        .:|||:::.|...||||.:..|...::........:.
Mouse   297 ----------------------------GLDSGFHSVDSGSKRWSGNESTDDFSELSFRISELAR 333

  Fly   378 AATLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSN----SSSNGSSPD 438
            ....||..........||.......|.....||..:.:....|.:||....:    |||....|
Mouse   334 DPRGPRQPREDGAGDGDLEQIDFIDSHVPGEDEDRSAAEEQLPSELSLVAGDVEKPSSSRREEP- 397

  Fly   439 QDDDIMLDHQERTVHHANGRSGKGLGNIQTYKEYKEALKQQRNQEISVYKQKHPNANHSPNDDED 503
                             .|...:....:|.::|      ::|.|      |:......||..|..
Mouse   398 -----------------AGEERRRPDTLQLWQE------RERKQ------QQQSGGWGSPRKDSV 433

  Fly   504 L------------SPSPPSISNGSSSNTLPKSIMKQNSNQIGHNGNGNGSANGNGVDDVVIP-KK 555
            |            :||..:..||.     |||    ::.|:|.:| |.|:..........:| ..
Mouse   434 LKRGIRAAGAGASAPSTQATCNGP-----PKS----STTQLGVSG-GQGAPTPPPTSQDPLPVSG 488

  Fly   556 PIQKVIPSRITEIKPASTSDIRSANSSDCLGYVKPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTT 620
            |:...:|..:..|:..::...||::.|..    .|.||
Mouse   489 PVTAPVPRPLGSIQRPNSFLFRSSSQSGS----SPSSP--------------------------- 522

  Fly   621 IKSPVSSTTKLGTVKTHRSVTWNHDIPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLP 685
                             .||......|.||                ||:||||.::|:||:..||
Mouse   523 -----------------ESVLRPRPFPQEK----------------ELISQLRQVLESRLQQPLP 554

  Fly   686 VDIASALTDGVILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELIC 750
            .|:|.||.:||:||.|||.:|||||..||||||.|.||:..:.|:||::||||||::||.|..:|
Mouse   555 EDLAEALANGVLLCQLANQLRPRSVPFIHVPSPAVPKLSALKSRKNVESFLEACRKMGVPEADLC 619

  Fly   751 SCEDVV 756
            |..|::
Mouse   620 SPSDLL 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR	<81..>286	CDD:443914	98/208 (47%)
		leucine-rich repeat	124..146	CDD:275380	8/21 (38%)
		leucine-rich repeat	147..167	CDD:275380	14/19 (74%)
		leucine-rich repeat	169..192	CDD:275380	10/22 (45%)
		leucine-rich repeat	193..215	CDD:275380	10/21 (48%)
		leucine-rich repeat	216..237	CDD:275380	10/20 (50%)
		leucine-rich repeat	238..260	CDD:275380	9/24 (38%)
		leucine-rich repeat	261..279	CDD:275380	8/17 (47%)
		CH_LRCH	667..755	CDD:409054	50/87 (57%)
		CH_SF	<1075..1099	CDD:469584
Lrch4	NP_666276.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		15/55 (27%)
		LRR 1. /evidence=ECO:0000255	41..64		11/22 (50%)
		leucine-rich repeat	46..69	CDD:275380	11/22 (50%)
		LRR	<65..>241	CDD:443914	84/179 (47%)
		LRR 2. /evidence=ECO:0000255	67..90		13/22 (59%)
		leucine-rich repeat	70..92	CDD:275380	11/21 (52%)
		LRR 3. /evidence=ECO:0000255	92..113		7/20 (35%)
		leucine-rich repeat	93..115	CDD:275380	8/21 (38%)
		LRR 4. /evidence=ECO:0000255	114..136		14/21 (67%)
		leucine-rich repeat	116..131	CDD:275380	11/14 (79%)
		leucine-rich repeat	138..160	CDD:275380	10/22 (45%)
		LRR 5. /evidence=ECO:0000255	138..158		9/19 (47%)
		LRR 6. /evidence=ECO:0000255	159..181		9/22 (41%)
		leucine-rich repeat	161..183	CDD:275380	10/21 (48%)
		LRR 7. /evidence=ECO:0000255	182..204		12/21 (57%)
		leucine-rich repeat	184..204	CDD:275380	10/19 (53%)
		leucine-rich repeat	206..228	CDD:275380	7/21 (33%)
		LRR 8. /evidence=ECO:0000255	206..226		7/19 (37%)
		LRR 9. /evidence=ECO:0000255	227..250		11/25 (44%)
		leucine-rich repeat	229..247	CDD:275380	8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..528		48/286 (17%)
		CH_LRCH4	534..639	CDD:409122	53/108 (49%)