DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrch and LRCH1

DIOPT Version :10

Sequence 1:NP_609834.2 Gene:Lrch / 35041 FlyBaseID:FBgn0032633 Length:1135 Species:Drosophila melanogaster
Sequence 2:NP_001157683.2 Gene:LRCH1 / 23143 HGNCID:20309 Length:763 Species:Homo sapiens


Alignment Length:794 Identity:271/794 - (34%)
Similarity:376/794 - (47%) Gaps:198/794 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 GTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHFSGELILTNRKLKDFPRTGTK-YSL 98
            |||:..|.|..|..|..      .:..|.|.|||.||||..||.|.|:.||||:||||... :.|
Human    38 GTGAPGGAGGGGGGSGG------FNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDL 96

  Fly    99 TDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPRE 163
            :|||.||||:||..|:|.|:..|..||.|.||||.||.|||::..|..||||:|..||||:||..
Human    97 SDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPAC 161

  Fly   164 ICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLY 228
            :|.|||:||:.|||:|.|||:|:|:|.| |.:||.|.|::..||.::|:|:|||.|::|.|:|..
Human   162 LCGLPLKVLIASNNKLGSLPEEIGQLKQ-LMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKV 225

  Fly   229 LPRELTCLSLISLDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQ 293
            ||:||..|||:..|.|.||:..:|:..|.|..|..|.||||||.||||.:|.:|.||:||:|..|
Human   226 LPQELVDLSLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQ 290

  Fly   294 A----TKDEKGSRSGGNYDGYTTLRRAP---RHNSSGNVLEASTTGSTNNQRRHQVDSGYNTSDG 351
            |    |.|..          |......|   :|...|               :...|||..:.:|
Human   291 ACQIKTADSL----------YLHTMERPHLHQHVEDG---------------KKDSDSGVGSDNG 330

  Fly   352 LDKRWSHDAPTKSKTDSPLHCVSNSTAATLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSP 416
             |||.|...|:...|                               .||....|.|::|...:..
Human   331 -DKRLSATEPSDEDT-------------------------------VSLNVPMSNIMEEEQIIKE 363

  Fly   417 TA----SPCKLSYAH---------SNSSSNGSSPDQDDDIMLDHQERTVHHANGRSGKGLGNIQT 468
            .:    ||.|..:..         .:|:::|...||..|           .|:|...:    ...
Human   364 DSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTD-----------RADGLHSE----FMN 413

  Fly   469 YKEYKEALKQQRNQEISVYKQKHPNANHSPNDDEDLS------------PSPPSISNGSSSNTLP 521
            ||...|..::....|..|:.|.....:.|.:.|.|::            ..|    ||.|::...
Human   414 YKARAEDCEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDP----NGLSTDITE 474

  Fly   522 KSIMKQNSNQIGHNGNGNGSANGNGVDD------VVIPKKPIQKV-------------IPSRITE 567
            :|::         |....|||....:.|      :.:...|:.:|             .|:.|.|
Human   475 RSVL---------NLYPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRE 530

  Fly   568 IKPASTSDIRSANSSDCLGYVKPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLG 632
            ..||.:.   :.||:...| :||:|                        ....|..|:|..|   
Human   531 NSPAVSP---TTNSTAPFG-LKPRS------------------------DPALILPPISFNT--- 564

  Fly   633 TVKTHRSVTW---NHDIPAEKLS-----------------FTMRREFDRQREETELMSQLRTIIE 677
               ..::.||   ::.:|:|..|                 ||:||:.::.|||.||:.|||..||
Human   565 ---LTQAQTWDSSSYSVPSEGDSDNVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIE 626

  Fly   678 TRLKMTLPVDIASALTDGVILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRI 742
            .|||::|..|:.:||.|||:||||.|::|||||||||||||.|.||:||:|||||:|||||||::
Human   627 MRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKL 691

  Fly   743 GVDEELICSCEDVV 756
            ||.|..:||..|::
Human   692 GVPEADLCSPCDIL 705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrchNP_609834.2 LRR <81..>286 CDD:443914 109/205 (53%)
leucine-rich repeat 124..146 CDD:275380 13/21 (62%)
leucine-rich repeat 147..167 CDD:275380 12/19 (63%)
leucine-rich repeat 169..192 CDD:275380 13/22 (59%)
leucine-rich repeat 193..215 CDD:275380 9/21 (43%)
leucine-rich repeat 216..237 CDD:275380 10/20 (50%)
leucine-rich repeat 238..260 CDD:275380 8/21 (38%)
leucine-rich repeat 261..279 CDD:275380 12/17 (71%)
CH_LRCH 667..755 CDD:409054 57/87 (66%)
CH_SF <1075..1099 CDD:469584
LRCH1NP_001157683.2 LRR 56..>272 CDD:443914 115/216 (53%)
leucine-rich repeat 76..98 CDD:275380 11/21 (52%)
leucine-rich repeat 99..121 CDD:275380 12/21 (57%)
leucine-rich repeat 122..144 CDD:275380 13/21 (62%)
leucine-rich repeat 145..160 CDD:275380 10/14 (71%)
leucine-rich repeat 167..189 CDD:275380 13/21 (62%)
leucine-rich repeat 190..212 CDD:275380 9/21 (43%)
leucine-rich repeat 213..234 CDD:275380 10/20 (50%)
leucine-rich repeat 235..257 CDD:275380 8/21 (38%)
leucine-rich repeat 258..277 CDD:275380 12/18 (67%)
CH_LRCH1 613..724 CDD:409119 60/93 (65%)
Blue background indicates that the domain is not in the aligned region.

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