DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and Lrch2

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_006528851.3	Gene:	Lrch2 / 210297	MGIID:	2147870	Length:	824	Species:	Mus musculus

Alignment Length:	847	Identity:	273/847 - (32%)
Similarity:	388/847 - (45%)	Gaps:	216/847 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GVGSAAGSAIGSGSASLPGSGTGSGSGIG-----------------------HAGNTSSSTSSAL 56
            |.|.|||...|.|.....|:|.|.|.|.|                       |.|:
Mouse    48 GGGGAAGGGGGGGGGGGGGAGAGGGGGCGGTVAVPIPVPTLFGQPFPNGPQWHPGS--------- 103

  Fly    57 LSHSQLTRSLERILEEAHFSGELILTNRKLKDFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTF 121
            |......|||:|.||||..||.|.|:.|||::||  |:.|.||||..||||||||.|:|.:|..|
Mouse   104 LQPQHTVRSLDRALEEAGNSGILSLSGRKLREFP--GSGYDLTDTTQADLSRNRFTEIPSDVWLF 166

  Fly   122 AFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDEL 186
            |.||||.||||.|::|||::|.|..||||::..|.||:||:.:..|||:||:||||:|.|:|:|:
Mouse   167 APLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEI 231

  Fly   187 GRLDQTLTDLDASYNQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASL 251
            |:| :.|.:||.|.|::..||.::|:|.||:.|::|.|:|..||.||..|.|:.||.|.||:..:
Mouse   232 GKL-KDLMELDVSCNEIQVLPQQMGKLHSLKELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEI 295

  Fly   252 PLEIRHMSTLVELQLENNPLTSPPASLCMRGLVHVFKFLETQA--TKDEKGSRSGGNYDGYTTLR 314
            |:..|.:..|..:.|:||||..|||.:|::|.||:||:|..||  ..|:|..    :.|..:..:
Mouse   296 PVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPD----SLDLPSLNK 356

  Fly   315 RAPRHNSSGNVLEASTTGSTNN---QRRHQVDSGYNTSDGLDKRWSHDAPTKSKTDSPLHCVSNS 376
            |.|         ....|.|..:   .:.|..|||..:.:| :||.|...|:...|.|
Mouse   357 RMP---------SQPLTDSMEDFYPNKNHGPDSGIGSDNG-EKRLSTTEPSDDDTIS-------- 403

  Fly   377 TAATLPRTLPSAVHSQADLMDASLTSSTSTIVDESLTLSPTASPCKLSYAHSNSSSNGSSPD-QD 440
                        :|||....:...||                        .::|...||.|| |.
Mouse   404 ------------LHSQVSESNREQTS------------------------RNDSHITGSKPDSQK 432

  Fly   441 DDIMLDH-----------QERTVHHANGRSGKGLGNIQTYKEYKE--ALKQQRNQEISVYKQKHP 492
            |..:.|.           :|...|         :|:..::.:.||  :.|.|:|:|....|:...
Mouse   433 DQEVYDFIDPNTEDVAVPEEGDTH---------IGSFVSFLKGKEKSSEKSQKNEEPPNEKKVDK 488

  Fly   493 NANHSPNDDEDLSP--------------------SPPSISNGSSSNTLPK--------------- 522
            .......:|:||..                    .|.|.....|.....:
Mouse   489 EQLLPEEEDDDLKEVTDLRKIAAQLLKQEQKNRWRPLSYRTSFSDKLFQRTRAAGRKSRILNHST 553

  Fly   523 SIMKQNSNQIGHNGNGNGSANGNGVDDVVIPKKPI---------QKVIPSRITEIKP-------- 570
            |:|:....|.........:..||.      |..|:         .:::..:..|.:|
Mouse   554 SVMRNKLKQTVECEKSVPADEGNS------PLSPLAWQPLENQKDQIVDQQWPESQPIIWQNEER 612

  Fly   571 ASTSDIRSANSSDCLGYVKPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVK 635
            ..:..||..       |.|.:|..||       |:|...:......:..:.:|||||.      :
Mouse   613 RRSKQIRKE-------YFKYKSTRKN-------SSGNENEEQESDNAHMSAQSPVSSE------E 657

  Fly   636 THRSVTWNH-----------------DIPAEKLSFTMRREFDRQREETELMSQLRTIIETRLKMT 683
            ..||..::|                 :..|....|||||:.:..|||.|.:.|||..:|:|||:.
Mouse   658 YDRSDGFSHGPFGLKPRSAFSRASRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVI 722

  Fly   684 LPVDIASALTDGVILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEEL 748
            ||.||.:||.|||:||||||::|||||||||||||.|.||:||:|||||:|||:||:::||.:|.
Mouse   723 LPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQER 787

  Fly   749 IC 750
            :|
Mouse   788 LC 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	32/54 (59%)
		LRR_4	124..161	CDD:289563	21/36 (58%)
		leucine-rich repeat	124..146	CDD:275380	14/21 (67%)
		leucine-rich repeat	147..167	CDD:275380	9/19 (47%)
		leucine-rich repeat	169..192	CDD:275380	13/22 (59%)
		leucine-rich repeat	193..215	CDD:275380	9/21 (43%)
		leucine-rich repeat	216..237	CDD:275380	9/20 (45%)
		leucine-rich repeat	238..260	CDD:275380	8/21 (38%)
		leucine-rich repeat	261..279	CDD:275380	9/17 (53%)
		CH	676..756	CDD:214479	51/75 (68%)
Lrch2	XP_006528851.3	PRK15370	<101..>315	CDD:185268	108/225 (48%)
		leucine-rich repeat	125..145	CDD:275380	10/21 (48%)
		leucine-rich repeat	146..168	CDD:275380	13/21 (62%)
		leucine-rich repeat	169..191	CDD:275380	14/21 (67%)
		leucine-rich repeat	192..207	CDD:275380	8/14 (57%)
		leucine-rich repeat	214..236	CDD:275380	13/22 (59%)
		leucine-rich repeat	237..259	CDD:275380	9/21 (43%)
		leucine-rich repeat	260..280	CDD:275380	9/19 (47%)
		leucine-rich repeat	282..304	CDD:275380	8/21 (38%)
		leucine-rich repeat	305..323	CDD:275380	9/17 (53%)
		CH_LRCH2	702..812	CDD:409120	58/88 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5676
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1953
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46074
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm43627
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3681
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010