Protein Alignment Lrch and Lrch

DIOPT Version :10

• Sequence 1: NP_609834.2
• Gene: Lrch / 35041
• FlyBaseID: FBgn0032633
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: XP_061516185.1
• Gene: Lrch / 1279439
• VectorBaseID: AGAMI1_009016
• Length: 1247
• Species: Anopheles gambiae
• Alignment Length: 1332
• Identity: 506/1332 - (37%)
• Similarity: 658/1332 - (49%)
• Gaps: 381/1332 - (28%)

  Fly     6 YQRLHSVAVGVGSAAGSAIGSGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERIL 70
            :|.||.|.:.         |.|:..:.|         ||.             .|||||||||||
Mosquito    20 HQPLHLVGMN---------GVGNVGIAG---------GHL-------------QSQLTRSLERIL 53

  Fly    71 EEAHFSGELILTNRKLKDFPRTGTKYSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIR 135
            |:||.||||.|:.|||||||:...||:|:||||||||||||.||||::|..||||.||:||||||
Mosquito    54 EDAHLSGELKLSGRKLKDFPKAAGKYNLSDTVIADLSRNRFCELPEDITCLAFLERLLVYHNTIR 118

  Fly   136 SIPESVKQLSSLTYLDLRSNQLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASY 200
            |:||:::.|.||||||||:||||.||||||.|||||||||||||.:|||||||::: ||:|||:.
Mosquito   119 SVPETIRGLHSLTYLDLRNNQLSVLPREICALPLQVLLVSNNRLATLPDELGRMEK-LTELDAAC 182

  Fly   201 NQLANLPARLGELRSLRSLSLRSNHLLYLPRELTCLSLISLDVSNNKIASLPLEIRHMSTLVELQ 265
            ||:.:||||:|:||::|||:||||.|:||||:||||.|..||:|:||||:||:|:|||::||:|:
Mosquito   183 NQITHLPARMGDLRNMRSLNLRSNQLVYLPRDLTCLELAFLDISSNKIATLPVELRHMTSLVDLE 247

  Fly   266 LENNPLTSPPASLCMRGLVHVFKFLETQATKDEKGSRSGGNYDGYTTLRRA--PRHNSSGNVLEA 328
            |.||||||||||||:||||||||:|||.|:::|| |::|  .||:.||||.  ...|||..:|:
Mosquito   248 LSNNPLTSPPASLCVRGLVHVFKYLETVASREEK-SKTG--IDGHATLRRTALSAKNSSSCLLD- 308

  Fly   329 STTGSTNNQRRHQVDSGYNTSD-GLD-KRWSHDAPTKSKTDS-------PLH--CV------SNS 376
                |....||..|||||.||| |.| |||.::....:.|.|       |||  |.      ||.
Mosquito   309 ----SQQRNRRANVDSGYCTSDGGFDGKRWKYEEDAHNFTISSSKWSPTPLHPGCTVMPANGSNH 369

  Fly   377 TAATLPRT----LPSAVH--------SQADLMDASLTSSTSTIV-DESLTLSPTASPCKLSYAH- 427
            ..|:.|.:    :..|.|        |..|...|..|..::.:. :|....:.|     ....|
Mosquito   370 KIASNPSSGGQHVALATHPNHGGPHESTVDTAVAGTTGGSNDVCWEEEFRKNAT-----FQEHHP 429

  Fly   428 -----SNSSSNGSSPDQD---DDIMLDHQERTVHHANGRSGKGLGNIQTYKEYKEALKQQRNQEI 484
                 ||::||..||:.|   |....|.:.||           |.|.|||:||||||:||||.:
Mosquito   430 DRKQLSNNNSNDISPEGDITPDGTKTDDKGRT-----------LSNYQTYREYKEALRQQRNLD- 482

  Fly   485 SVYKQK-HP-------NANHSPNDDEDLSPSPPSISN----GSSSNTLPKS----IMKQNSNQIG 533
            |||:.| ||       :|..||  ..::||...|||:    .|||.:.|.|    |..|..|||.
Mosquito   483 SVYRSKDHPLTPDSAGSATDSP--VSNVSPYTKSISSSSVYSSSSQSSPVSPHHTIGVQKMNQIN 545

  Fly   534 HNGNG--------------------NGSANGNGVDDVV--IP-KKPIQKVIPSR----------I 565
            .|.|.                    ||| .|..|||..  .| |:|:|||||||          .
Mosquito   546 ANPNSSYHMSGATGTHSSPLLSPNRNGS-QGTTVDDSTGGTPNKRPVQKVIPSRNIGSLHHNQSP 609

  Fly   566 TEIK-------PASTS------------------DIRSANSS--DCLGYVKPQSPMKNGTS---- 599
            |.:.       .||||                  .:.|||.|  :...||||.||.|:.:.
Mosquito   610 THLNGNHHASGAASTSVSNGSHGKNALSNGAGKGSLSSANGSVNNEYAYVKPNSPCKSTSGVLAH 674

  Fly   600 ---------KFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTV-------KTHRSVTWNHDIPA 648
                     |....|.||    :|...:|  :.|:::|  :|.|       |.:::|:||.|:|.
Mosquito   675 NNIPPSSIPKPTAPNSGG----LGSPGAT--QKPLTAT--VGYVNNAKPGQKANKTVSWNRDVPT 731

  Fly   649 EKLSFTMRREFDRQREETELMSQLRTIIETRLKMTLPVDIASALTDGVILCHLANYVRPRSVASI 713
            ||||||||||||:|:|||||:.|||.||||||||:||.|||.||.|||:||||||.||||||.||
Mosquito   732 EKLSFTMRREFDKQKEETELIEQLRQIIETRLKMSLPQDIAPALMDGVVLCHLANLVRPRSVGSI 796

  Fly   714 HVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELICSCEDVVPQIEPQQPQLPRADDDYDADVY 778
            ||||..|.||||||||||||.||:|||:|||||||||||:|:||....:....|..|:|..|.
Mosquito   797 HVPSSAVPKLTMARCRRNVDYFLDACRKIGVDEELICSCQDIVPPTVAESSSTPLEDNDRKAG-- 859

  Fly   779 VQDDGSISRSNDSSHLQCSDDCNSSSNHINRVPNALALLRTVSALIAMDENPYHQQLHHHLQLQL 843
             .|||..|:....:               .|.||.||:.||::||:::   |..|.:.......|
Mosquito   860 -YDDGHGSQETSPT---------------PRPPNPLAMYRTIAALLSL---PVAQSVSPPSPSPL 905

  Fly   844 EQQHFEQEQFSEP-------------------TTCSQQQEQML--------------LLQQQQQQ 875
               .|.:...|.|                   |..|.:.|..|              :|.||..|
Mosquito   906 ---GFLRRPRSPPPPPPPTTQSVSAITAAATNTNSSTEPETNLNCEIMESYGFSTVGILDQQGSQ 967

  Fly   876 LEHVLYENGLPRAENDD--------GVEDRDD-----DIGKRQQQLATVGQMLLKAKQKTYEKIK 927
            :...|...|....|..|        |.||..:     |:.|         ..:..|:::.:...:
Mosquito   968 IVGDLATTGEKMFEYSDQPTQRSYRGSEDHRNVPVTLDLPK---------SSVKPARKRKFPSTR 1023

  Fly   928 HNLLSAHGQHNFQGNNNNRMLHTIVENEHDVAAAGPAGHYQIIDEKQEEDPY------------- 979
            .|..: ||..:.|.|.|    ..|.|.|:|    ...|.::...:..:|..|
Mosquito  1024 TNRRN-HGSTDIQSNLN----EIIEECEYD----SDIGKFRCRTDDADEMGYGLRDYEDSETSVT 1079

  Fly   980 ---------------------------QP-----------KSEDLKDAAALGNATK--------- 997
                                       ||           .|.|| |...|.:.|:
Mosquito  1080 SCDDDLNDVDVGCDDDVGGEAFTPTNAQPTMADSIVRRNIPSNDL-DTPILSSKTETSGTENFNI 1143

  Fly   998 -------------EAISKRIEFFEQQKSGKPKL------EVFSIYLPKEKTKELELEQKIKAKTN 1043
                         :.::|||||||...:...|:      .:.:..:.|.:.:.:|..|...|  |
Mosquito  1144 VQYDVDSIKTDEHKVVTKRIEFFENAANSSMKILNCETSAILNTAVIKYEGEIVETPQMSIA--N 1206

  Fly  1044 EAGSSILKHDSHTL----TVILSCVFIATFLW 1071
            |..|:  |:|||..    .||.:.:.:.|||:
Mosquito  1207 EPYSA--KNDSHRRESDHPVISTILCLGTFLF 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR	<81..>286	CDD:443914	146/204 (72%)
		leucine-rich repeat	124..146	CDD:275380	14/21 (67%)
		leucine-rich repeat	147..167	CDD:275380	17/19 (89%)
		leucine-rich repeat	169..192	CDD:275380	18/22 (82%)
		leucine-rich repeat	193..215	CDD:275380	13/21 (62%)
		leucine-rich repeat	216..237	CDD:275380	15/20 (75%)
		leucine-rich repeat	238..260	CDD:275380	14/21 (67%)
		leucine-rich repeat	261..279	CDD:275380	14/17 (82%)
		CH_LRCH	667..755	CDD:409054	70/87 (80%)
		CH_SF	<1075..1099	CDD:469584
Lrch	XP_061516185.1	None