DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrch and lrch1

DIOPT Version :9

Sequence 1:	NP_609834.2	Gene:	Lrch / 35041	FlyBaseID:	FBgn0032633	Length:	1135	Species:	Drosophila melanogaster
Sequence 2:	XP_002935158.2	Gene:	lrch1 / 100492607	XenbaseID:	XB-GENE-6033840	Length:	708	Species:	Xenopus tropicalis

Alignment Length:	780	Identity:	275/780 - (35%)
Similarity:	375/780 - (48%)	Gaps:	174/780 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SGSASLPGSGTGSGSGIGHAGNTSSSTSSALLSHSQLTRSLERILEEAHFSGELILTNRKLKDFP 90
            ||||.||.....|.:|    |.|:.|..      ..:.|.|||.||||..||.|.::.||||:||
Frog    15 SGSALLPAQLQHSAAG----GVTNFSLK------LPVNRGLERALEEAASSGVLNVSARKLKEFP 69

  Fly    91 RTGTKYSLTDTVIADLSRNRFAELPEEVTTFAFLETLLLYHNTIRSIPESVKQLSSLTYLDLRSN 155
            ||.....|:|||.||.|:||..|:|.||..|..||.|.||||.||.||.:...|..||||::..|
Frog    70 RTSGSPDLSDTVRADFSKNRLTEVPVEVCQFVSLEALNLYHNCIRIIPHAFVNLQMLTYLNIGRN 134

  Fly   156 QLSSLPREICFLPLQVLLVSNNRLTSLPDELGRLDQTLTDLDASYNQLANLPARLGELRSLRSLS 220
            ||||:|..:|.|||:||:.:||:|.|||:|:|:| |.|.:||.|.|::|:||.::|.|:|||.|:
Frog   135 QLSSVPACVCGLPLKVLIANNNKLGSLPEEIGQL-QHLMELDVSCNEIASLPQQIGLLKSLRDLN 198

  Fly   221 LRSNHLLYLPRELTCLSLISLDVSNNKIASLPLEIRHMSTLVELQLENNPLTSPPASLCMRGLVH 285
            :|.|||..||.|:..|.|:.||.|.||:..|||..|.|..|..|.||||||.||||.:|::|.||
Frog   199 VRRNHLKALPPEIVDLPLVKLDFSCNKVLVLPLCFRKMVQLQVLILENNPLQSPPAQICIKGKVH 263

  Fly   286 VFKFLETQATKDEKGSRSGGNYDGY--TTLRR--APRHNSSGNVLEASTTGSTNNQRRHQVDSGY 346
            :||:|..|:.:.||..      ||:  .:|.|  .|:|.....:.:....       :...|||.
Frog   264 IFKYLSMQSCQMEKTG------DGFYLHSLERPNLPQHVEESGIEDIFPA-------KKDSDSGV 315

  Fly   347 NTSDGLDKRWSHDAPTKSKTDSPLHCVSNSTAATLPRTLPSAVHSQADLMDASLTSSTSTIVDES 411
            .:..| :||.|...|          |..:||:.::|.   |.:..:.:|:       ...||::.
Frog   316 GSDSG-EKRLSTIEP----------CDEDSTSPSVPM---SDILEEENLL-------KEDIVEQQ 359

  Fly   412 L-TLSPTASP-CKLSYAHSNSSSN-------------GSSPDQDDDIMLDHQERT---VHHANGR 458
            | .|....|| ..||.|...:..|             ||....|:.:.:  ||.:   :.:....
Frog   360 LNNLLQVESPQNSLSSASDRAYQNETETLQMEYLQYEGSRSAFDEPLQI--QEESPWLIENTRNA 422

  Fly   459 SGKGLGNIQTYKEYKEA---------LKQQRNQEISVYK-QKHPNA---NHSPNDDEDLSPSPPS 510
            |.|...|.....:.:||         |..:....::||. ::.|.:   :.|.|...:|..| |.
Frog   423 SEKQELNATMIDQLREAVVMLQDPTRLSLEIEDTVNVYPLERIPESALNDTSVNGQVELQMS-PI 486

  Fly   511 ISNGSSSNTLPKSIMKQNSNQIGHNGNGNGSANGNGVDDVVIPKKPIQKVIPSRITEIKPASTSD 575
            :.|..:..||    ..|||.|...|                                    ||..
Frog   487 LQNDMTIETL----ASQNSPQETEN------------------------------------STPT 511

  Fly   576 IRSANSSDCLGYVKPQSPMKNGTSKFNTSNGGGVQTTVGIVSSTTIKSPVSSTTKLGTVKTHRSV 640
            :...:|:...| :||:|.                       .|.|: .|:|..      |..::.
Frog   512 LSPVHSTAAFG-LKPRSD-----------------------PSLTL-PPISFN------KLTQAQ 545

  Fly   641 TW---NHDIPAE-----------------KLSFTMRREFDRQREETELMSQLRTIIETRLKMTLP 685
            .|   |.||.||                 ...||:||:.::.|||.|.:..||..||.||||.||
Frog   546 NWDSNNMDISAEGGIDNVFIRPQRNLESVDPQFTIRRKMEQMREEKEHVDHLRENIEIRLKMGLP 610

  Fly   686 VDIASALTDGVILCHLANYVRPRSVASIHVPSPGVNKLTMARCRRNVDNFLEACRRIGVDEELIC 750
            .|:..||.|||:||||.|.:|||||.|||||||.|.||:||:|||||:|||:||||:||.||.:|
Frog   611 NDLGPALMDGVVLCHLVNQIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRRMGVPEEKLC 675

Fly 751 750
Frog 676 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrch	NP_609834.2	LRR_8	124..179	CDD:290566	30/54 (56%)
		LRR_4	124..161	CDD:289563	21/36 (58%)
		leucine-rich repeat	124..146	CDD:275380	12/21 (57%)
		leucine-rich repeat	147..167	CDD:275380	11/19 (58%)
		leucine-rich repeat	169..192	CDD:275380	12/22 (55%)
		leucine-rich repeat	193..215	CDD:275380	10/21 (48%)
		leucine-rich repeat	216..237	CDD:275380	10/20 (50%)
		leucine-rich repeat	238..260	CDD:275380	11/21 (52%)
		leucine-rich repeat	261..279	CDD:275380	12/17 (71%)
		CH	676..756	CDD:214479	53/75 (71%)
lrch1	XP_002935158.2	PRK15370	<58..>255	CDD:185268	105/197 (53%)
		leucine-rich repeat	103..125	CDD:275380	12/21 (57%)
		leucine-rich repeat	126..146	CDD:275380	11/19 (58%)
		leucine-rich repeat	148..170	CDD:275380	12/22 (55%)
		leucine-rich repeat	171..193	CDD:275380	10/21 (48%)
		leucine-rich repeat	194..214	CDD:275380	10/19 (53%)
		leucine-rich repeat	216..238	CDD:275380	11/21 (52%)
		leucine-rich repeat	266..286	CDD:275378	7/25 (28%)
		CH	611..684	CDD:214479	45/65 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I1999
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186976at33208
OrthoFinder	1	1.000	-	-		FOG0000912
OrthoInspector	1	1.000	-	-		otm48792
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X454
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060