Protein Alignment CG6380 and PPP1R2C

DIOPT Version :10

• Sequence 1: NP_609833.1
• Gene: CG6380 / 35040
• FlyBaseID: FBgn0032632
• Length: 293
• Species: Drosophila melanogaster
• Sequence 2: NP_079486.1
• Gene: PPP1R2C / 80316
• HGNCID: 16324
• Length: 202
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 54/207 - (26%)
• Similarity: 89/207 - (42%)
• Gaps: 59/207 - (28%)

  Fly     6 VKGILK----SGNN---SAQFS---------LKAAKFDEVNILATFHPAGKDYGHMIIDEPKTPF 54
            :|||||    ||::   |.|.|         .|:.|:||.:|||......:||..|..:||.|.:
Human    11 IKGILKNKSSSGSSVATSGQQSGGTIQDVKRKKSQKWDESSILAAHRATYRDYDLMKANEPGTSY 75

  Fly    55 VFEEDLPKELDTNALIEKLRHTSKSEMPAFGIEG----DSEESSADEDFPESVEEKVRRM----- 110
            :..:|..:        :.:|.. :.|....|:||    |:.:.|.:.|..||.|..:|::
Human    76 MSVQDNGE--------DSVRDV-EGEDSVRGVEGKEATDASDHSCEVDEQESSEAYMRKILLHKQ 131

  Fly   111 ----EFERRRKVHYKEFYSVPLARRLIADEFAELTSSEFNIHCEGGMESCEACSENNQLDGEASN 171
                :||.||::||.|..::.|||:|:..|..                     ||:|:.:.....
Human   132 EKKRQFEMRRRLHYNEELNIKLARQLMWKELQ---------------------SEDNENEETPQG 175

  Fly   172 LTQTKYSYSESQ 183
            ..:.|.:..||:
Human   176 TNEEKTAAEESE 187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6380	NP_609833.1	IPP-2	24..136	CDD:461504	36/124 (29%)
PPP1R2C	NP_079486.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		14/39 (36%)
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17		4/4 (100%)
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55		6/11 (55%)
		IPP-2	45..170	CDD:461504	40/154 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..118		11/55 (20%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	144..147		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..202		6/47 (13%)