Protein Alignment CG6380 and PPP1R2B

DIOPT Version :10

• Sequence 1: NP_609833.1
• Gene: CG6380 / 35040
• FlyBaseID: FBgn0032632
• Length: 293
• Species: Drosophila melanogaster
• Sequence 2: NP_996740.2
• Gene: PPP1R2B / 153743
• HGNCID: 16318
• Length: 205
• Species: Homo sapiens
• Alignment Length: 231
• Identity: 70/231 - (30%)
• Similarity: 105/231 - (45%)
• Gaps: 63/231 - (27%)

  Fly     6 VKGILKSGNNSA----------------QFSLKAAKFDEVNILATFHPAGKDYGHMIIDEPKTPF 54
            :|||||:..::.                :.|.|:.|:||:|||||:|||.|.||.|.||||..|:
Human    11 IKGILKNKTSTTSSMVASAEQPRRSVDEELSKKSQKWDEINILATYHPADKGYGLMKIDEPSPPY 75

  Fly    55 VF----EEDLPKELDT------NALIEKLRHTSKSEMPAFGIEGDSEESSADEDFPESVEEKVRR 109
            ..    :||..::.:|      :.|.:||......| |.:.|:  .:|||.:||...|.||:.::
Human    76 HSMMGDDEDACRDTETTEAMAPDILAKKLAAAEGLE-PKYRIQ--EQESSGEEDSDLSPEEREKK 137

  Fly   110 MEFERRRKVHYKEFYSVPLARRLIADEFAELTSSEFNIHCEGGMESCEACSENNQLDGEASNLTQ 174
            .:||.|||:||.|..::.|||:||:.:..:....|         |..|..      |||:.|.
Human   138 RQFEMRRKLHYNEGLNIKLARQLISKDLHDDDEDE---------EMLETA------DGESMNT-- 185

  Fly   175 TKYSYSESQSEYRISDHSEPEPGFSPSHHCYQKLKA 210
                             .|...|.:||.....||::
Human   186 -----------------EESNQGSTPSDQQQNKLRS 204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6380	NP_609833.1	IPP-2	24..136	CDD:461504	50/121 (41%)
PPP1R2B	NP_996740.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		6/32 (19%)
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17		4/4 (100%)
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55		7/11 (64%)
		IPP-2	45..164	CDD:461504	50/121 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..142		12/33 (36%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	147..150		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..205		13/76 (17%)