Protein Alignment CG12620 and Ppp1r2

DIOPT Version :10

• Sequence 1: NP_609828.2
• Gene: CG12620 / 35034
• FlyBaseID: FBgn0032626
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_080076.1
• Gene: Ppp1r2 / 66849
• MGIID: 1914099
• Length: 206
• Species: Mus musculus
• Alignment Length: 172
• Identity: 44/172 - (25%)
• Similarity: 76/172 - (44%)
• Gaps: 36/172 - (20%)

  Fly     1 MTTKRTRFDKMNLGVPVH--------------SDPYE---VENESASSIKRETGEKVMSHKELME 48
            ::.|..::|:||:....|              :.||.   .::|.|.|  ...|.:||:...|.:
Mouse    41 LSKKSQKWDEMNILATYHPADKDYGLMKIDEPNTPYHNMIGDDEDAYS--DSEGNEVMTPDILAK 103

  Fly    49 KLHKEVKLTTPDFFAHDPSCSSDDSEDFEFLETIKERARRISFVRRRKLHYTEFSTVELARRLIR 113
            || ...:.:.|.:...:...|.::..|.    :.:||.::..|..:|||||.|...::|||:||.
Mouse   104 KL-AAAEGSEPKYRTREQESSGEEDNDL----SPEEREKKRQFEMKRKLHYNEGLNIKLARQLIS 163

  Fly   114 EEFTESSESQLSVDDEHISEIAE------EECPPCGTDSDDL 149
            ::..:..|      ||.::|.|:      ||.....|.||.|
Mouse   164 KDLHDDDE------DEEMAETADGDSMNVEESSQGSTTSDHL 199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12620	NP_609828.2	IPP-2	<18..115	CDD:461504	29/113 (26%)
Ppp1r2	NP_080076.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		Required for binding PPP1CC	12..17
		Required for binding the 'RVXF' binding groove of PPP1CC	44..56		4/11 (36%)
		IPP-2	46..165	CDD:461504	32/125 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..143		17/74 (23%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity	148..151		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	164..206		11/42 (26%)