DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12620 and PPP1R2

DIOPT Version :9

Sequence 1:	NP_001260525.1	Gene:	CG12620 / 35034	FlyBaseID:	FBgn0032626	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_001278433.1	Gene:	PPP1R2 / 5504	HGNCID:	9288	Length:	206	Species:	Homo sapiens

Alignment Length:	207	Identity:	48/207 - (23%)
Similarity:	77/207 - (37%)	Gaps:	58/207 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTKRTRFDKMNLGVPVH--------------SDPYEV---ENESASSIKRETGEKVMSHKELME 48
            ::.|..::|:||:....|              |.||..   ::|.|.|....|  :.|:...|..
Human    40 LSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMMGDDEDACSDTEAT--EAMAPDILAR 102

  Fly    49 KLHKEVKLTTPDFFAHDPSCSSDDSEDFEFLETIKERARRISFVRRRKLHYTEFSTVELARRLIR 113
            ||.....| .|.:...:...|.::..|....|..|::.:   |..:|||||.|...::|||:||.
Human   103 KLAAAEGL-EPKYRIQEQESSGEEDSDLSPEERGKKKRQ---FEMKRKLHYNEGLNIKLARQLIS 163

  Fly   114 EEFTESSESQLSVDDEHISEIAEEECPPCGTDSDDLLPYFQYDRATDQSMISDDSLPKEDPEPGF 178
            ::..:..|      ||.:.|.|:.|                             |:..|:...|.
Human   164 KDLHDDDE------DEEMLETADGE-----------------------------SMNTEESNQGS 193

  Fly   179 HPAHHCYNKLIS 190
            .|:....|||.|
Human   194 TPSDQQQNKLRS 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12620	NP_001260525.1	IPP-2	<21..111	CDD:282789	26/92 (28%)
PPP1R2	NP_001278433.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		0/3 (0%)
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55		4/11 (36%)
		IPP-2	45..164	CDD:282789	33/124 (27%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	148..151		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..206		14/77 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1321970at2759
OrthoFinder	1	1.000	-	-		FOG0003529
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12398
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920