Protein Alignment CG12620 and PPP1R2

DIOPT Version :10

• Sequence 1: NP_609828.2
• Gene: CG12620 / 35034
• FlyBaseID: FBgn0032626
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_001278433.1
• Gene: PPP1R2 / 5504
• HGNCID: 9288
• Length: 206
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 48/207 - (23%)
• Similarity: 77/207 - (37%)
• Gaps: 58/207 - (28%)

  Fly     1 MTTKRTRFDKMNLGVPVH--------------SDPYEV---ENESASSIKRETGEKVMSHKELME 48
            ::.|..::|:||:....|              |.||..   ::|.|.|....|  :.|:...|..
Human    40 LSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMMGDDEDACSDTEAT--EAMAPDILAR 102

  Fly    49 KLHKEVKLTTPDFFAHDPSCSSDDSEDFEFLETIKERARRISFVRRRKLHYTEFSTVELARRLIR 113
            ||.....| .|.:...:...|.::..|....|..|::.:   |..:|||||.|...::|||:||.
Human   103 KLAAAEGL-EPKYRIQEQESSGEEDSDLSPEERGKKKRQ---FEMKRKLHYNEGLNIKLARQLIS 163

  Fly   114 EEFTESSESQLSVDDEHISEIAEEECPPCGTDSDDLLPYFQYDRATDQSMISDDSLPKEDPEPGF 178
            ::..:..|      ||.:.|.|:.|                             |:..|:...|.
Human   164 KDLHDDDE------DEEMLETADGE-----------------------------SMNTEESNQGS 193

  Fly   179 HPAHHCYNKLIS 190
            .|:....|||.|
Human   194 TPSDQQQNKLRS 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12620	NP_609828.2	IPP-2	<18..115	CDD:461504	30/113 (27%)
PPP1R2	NP_001278433.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		0/3 (0%)
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55		4/11 (36%)
		IPP-2	45..165	CDD:461504	33/125 (26%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	148..151		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	164..206		14/77 (18%)