DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ApepP and YFR006W

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_116661.1	Gene:	YFR006W / 850556	SGDID:	S000001902	Length:	535	Species:	Saccharomyces cerevisiae

Alignment Length:	471	Identity:	103/471 - (21%)
Similarity:	157/471 - (33%)	Gaps:	177/471 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 WFLNLRGSDIDFNPVFFS------YLIVTN------------------------DELLLFVDSGK 242
            :|.:|.|.||..:.:.|:      .|.:.|                        ||.|...|.||
Yeast   123 YFYHLSGVDIPASAILFNCSTDKLTLFLPNIDEEDVIWSGMPLSLDEAMRVFDIDEALYISDLGK 187

  Fly   243 ----------LPTDFVQHQKENNVQISVLP------YASIGIEISKIVSTRESKIWIAPTSSYYL 291
                      ..|| :.:..:.|:..|::|      ||        :..||..|.|       |.
Yeast   188 KFKELQDFAIFTTD-LDNVHDENIARSLIPSDPNFFYA--------MDETRAIKDW-------YE 236

  Fly   292 TALIPKSRRIQEVTPICVLKAIKNDVEIAGFINSHIRDGVALCQYFAWLEDQVNKGAEVDEMSGA 356
            ...|.|:.:|.:.:.:.|:.|:.                                 .|::|:...
Yeast   237 IESIRKACQISDKSHLAVMSALP---------------------------------IELNELQIQ 268

  Fly   357 DKLESFRSTKDKYMGLSFTTISASGPNGSVIHYHPKKETNRKINDKEIYLCDSGAQYLDGTTDVT 421
            .:.| :.:|:.....|.:..|..|||....:||....|   .|..|...|.|:||::...|:|:|
Yeast   269 AEFE-YHATRQGGRSLGYDPICCSGPACGTLHYVKNSE---DIKGKHSILIDAGAEWRQYTSDIT 329

  Fly   422 RTL-HFGEPTEFQKEAYTRVLKGQLSFGSTVFPAKVKGQVLDTLARKAL----WDVGL------- 474
            |.. ..|:.|...:|.|..||..|......:.|. .|...|..|..|.|    ..:|:
Yeast   330 RCFPTSGKFTAEHREVYETVLDMQNQAMERIKPG-AKWDDLHALTHKVLIKHFLSMGIFKKEFSE 393

  Fly   475 -----------DYGHGTGHGVGHFLNVHEGPMGVGIRLMPDDPG-----------LQANMFISNE 517
                       .|.||.||.:|  |:||:    ||.....|||.           |:.||.|:||
Yeast   394 DEIFKRRASCAFYPHGLGHMLG--LDVHD----VGGNPNYDDPDPMFRYLRIRRPLKENMVITNE 452

  Fly   518 PGFYQD----GEF-----------------------GIRVEDIVQIVPGQVAHNFSNRGALTFKT 555
            ||.|.:    .||                       |:|:||.:.:         :..|......
Yeast   453 PGCYFNQFLIKEFLEKHPERLEVVDMSVLKRYMYVGGVRIEDDILV---------TKDGYENLTG 508

  Fly   556 ITMCPKQ-TKMIKKEL 570
            ||..|.: .|:::|.|
Yeast   509 ITSDPDEIEKIVQKGL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473
		Creatinase_N_2	158..318	CDD:318430	31/155 (20%)
		APP	321..545	CDD:238518	65/284 (23%)
		Peptidase_M24_C	551..613	CDD:318429	6/21 (29%)
YFR006W	NP_116661.1	AMP_N	72..192	CDD:198079	14/68 (21%)
YFR006W	NP_116661.1	Prolidase	237..508	CDD:238520	71/323 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810