DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ApepP and APP1

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001328936.1	Gene:	APP1 / 829829	AraportID:	AT4G36760	Length:	652	Species:	Arabidopsis thaliana

Alignment Length:	653	Identity:	251/653 - (38%)
Similarity:	382/653 - (58%)	Gaps:	58/653 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TQILTRLRELMLRAQVGDSCGISAYIVPSDDAHQSEYQCQHDERRSFVSGFDGSAGTAVITTETA 70
            ::||:.||.||    ...|..:.|.:|||:|.|||||....|:||.|||||.||||.|:||.:.|
plant     2 SEILSSLRSLM----ASHSPPLDALVVPSEDYHQSEYVSARDKRREFVSGFSGSAGLALITKKEA 62

  Fly    71 LLWTDGRYYQQAEKQLDSNWVLMRDGLSATPSIGAWLAKNLPKGSFVGVDPRLLSFRVWKPIETE 135
            .|||||||:.||.:||...|.|||.|  ..|.:..|::.|||:.:.:|||...:|..........
plant    63 RLWTDGRYFLQALQQLSDEWTLMRMG--EDPLVEVWMSDNLPEEANIGVDSWCVSVDTANRWGKS 125

  Fly   136 LSSAECQLVPIEGNLIDEVWGEDQPPQTSNKIITLKLEHSGVTIAKKWDVVRQQLKEKNADALVV 200
            .:....:|:....:|:|||| :.:||...:.::...||.:|.:::.|::.:|.:||::.|..||:
plant   126 FAKKNQKLITTTTDLVDEVW-KSRPPSEMSPVVVHPLEFAGRSVSHKFEDLRAKLKQEGARGLVI 189

  Fly   201 SALDEIAWFLNLRGSDIDFNPVFFSYLIVTNDELLLFVDSGKLPTDFVQHQKENNVQISVLPYAS 265
            :||||:||..|:||:|:.:.||..::.|:|.|...|:||..|:..:  .:...|.:.:.|..|..
plant   190 AALDEVAWLYNIRGTDVAYCPVVHAFAILTTDSAFLYVDKKKVSDE--ANSYFNGLGVEVREYTD 252

  Fly   266 IGIEISKIVSTR------------------------ESKIWIAPTS-SYYLTALIPKSRRIQEVT 305
            :..:::.:.|.|                        ..::|:.|.| .|.|.:.:...:.:.:.:
plant   253 VISDVALLASDRLISSFASKTVQHEAAKDMEIDSDQPDRLWVDPASCCYALYSKLDAEKVLLQPS 317

  Fly   306 PICVLKAIKNDVEIAGFINSHIRDGVALCQYFAWLEDQVNK--GA------------------EV 350
            ||.:.||:||.||:.|..|:|:|||.|:.||..||::|:.:  ||                  ::
plant   318 PISLSKALKNPVELEGIKNAHVRDGAAVVQYLVWLDNQMQELYGASGYFLEAEASKKKPSETSKL 382

  Fly   351 DEMSGADKLESFRSTKDKYMGLSFTTISASGPNGSVIHYHPKKETNRKINDKEIYLCDSGAQYLD 415
            .|::.:|||||.|::|:.:.||||.|||:.|.|.:||||.|:.|...:::..:||||||||||||
plant   383 TEVTVSDKLESLRASKEHFRGLSFPTISSVGSNAAVIHYSPEPEACAEMDPDKIYLCDSGAQYLD 447

  Fly   416 GTTDVTRTLHFGEPTEFQKEAYTRVLKGQLSFGSTVFPAKVKGQVLDTLARKALWDVGLDYGHGT 480
            ||||:|||:|||:|:..:||.||.|.||.::.|:..||....|..||.|||..||..||||.|||
plant   448 GTTDITRTVHFGKPSAHEKECYTAVFKGHVALGNARFPKGTNGYTLDILARAPLWKYGLDYRHGT 512

  Fly   481 GHGVGHFLNVHEGPMGVGIRLMPDDPGLQANMFISNEPGFYQDGEFGIRVEDIVQIVPGQVAHNF 545
            |||||.:|.|||||..|..|....:..|||.|.:::|||:|:||.||||:|:::.:...:...||
plant   513 GHGVGSYLCVHEGPHQVSFRPSARNVPLQATMTVTDEPGYYEDGNFGIRLENVLVVNDAETEFNF 577

  Fly   546 SNRGALTFKTITMCPKQTKMIKKELLSDAEVKLLNSYHQQVWDTLSPILSREGDEFTLSWLKKEV 610
            .::|.|.|:.||..|.|.|:|..:.|:..|:..||:||.:..|.|:|.:    ::..:.||||..
plant   578 GDKGYLQFEHITWAPYQVKLIDLDELTREEIDWLNTYHSKCKDILAPFM----NQTEMEWLKKAT 638

  Fly   611 QPI 613
            :|:
plant   639 EPL 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473	60/144 (42%)
		Creatinase_N_2	158..318	CDD:318430	47/184 (26%)
		APP	321..545	CDD:238518	113/243 (47%)
		Peptidase_M24_C	551..613	CDD:318429	21/61 (34%)
APP1	NP_001328936.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	226	1.000	Domainoid score	I672
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6424
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62675
OrthoDB	1	1.010	-	-		D417805at2759
OrthoFinder	1	1.000	-	-		FOG0001510
OrthoInspector	1	1.000	-	-		otm2439
orthoMCL	1	0.900	-	-		OOG6_100896
Panther	1	1.100	-	-	O	PTHR43763
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790