DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ApepP and XPNPEP2

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_003390.4	Gene:	XPNPEP2 / 7512	HGNCID:	12823	Length:	674	Species:	Homo sapiens

Alignment Length:	629	Identity:	261/629 - (41%)
Similarity:	378/629 - (60%)	Gaps:	48/629 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STTQILTRLRELMLRAQVGDSCGISAYIVPSDDAHQSEYQCQHDERRSFVSGFDGSAGTAVITTE 68
            :||..||.||:.|      .:..:||||:|..|||.:||..||||||::::||.|||||||:|.:
Human    49 NTTMSLTALRQQM------QTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMK 107

  Fly    69 TALLWTDGRYYQQAEKQLDSNWVLMRDGLSATPSIGAWLAKNLPKGSFVGVDPRLLSFRVWKPIE 133
            .|.:|||.||:.|||:|:|.||.|.:: :..|| |..||...:|.|..||.||.|||...|:..:
Human   108 KAAVWTDSRYWTQAERQMDCNWELHKE-VGTTP-IVTWLLTEIPAGGRVGFDPFLLSIDTWESYD 170

  Fly   134 TELSSAECQLVPIEGNLIDEVWGEDQPPQTSNKIITLKLEHSGVTIAKKWDVVRQQLK--EKNAD 196
            ..|..:..|||.|..||:|.|||.::||..:..|..|:...:|.|..:|...||.|::  :|...
Human   171 LALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPT 235

  Fly   197 ALVVSALDEIAWFLNLRGSDIDFNPVFFSYLIVTNDELLLFVDSGKLPTD-------------FV 248
            |:::|||:|.||..|||.|||.:||.|:||.::|:..:.||.:..:..::             .|
Human   236 AVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCV 300

  Fly   249 QHQKENNVQISVLPYASIGIEISKIVSTRESKIWIAPTSSYY-LTALIPKSRRIQEV-TPICVLK 311
            |.:..:.|:.|:..| |:|          :.:|||..:.:.| :..:|||.:.:.:. :|:.:.|
Human   301 QIEDYSQVRDSIQAY-SLG----------DVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTK 354

  Fly   312 AIKNDVEIAGFINSHIRDGVALCQYFAWLEDQVNKGAEVDEMSGADKLESFRSTKDKYMGLSFTT 376
            |:||..|.|....||:||.||:.:|..|||..|.||. |||.|||:.::.||..:....|.||.|
Human   355 AVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGT-VDEFSGAEIVDKFRGEEQFSSGPSFET 418

  Fly   377 ISASGPNGSVIHYHPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHFGEPTEFQKEAYTRVL 441
            |||||.|.::.||.|.||.|||::..|:||.|||.||.|||||:|||:|:|.|:.||||||||||
Human   419 ISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVL 483

  Fly   442 KGQLSFGSTVFPAKVKGQVLDTLARKALWDVGLDYGHGTGHGVGHFLNVHEGPMGVGIRLMPDDP 506
            .|.:.....:|||...|::::..||:||||.||:||||||||:|:||.|||.|:|    ...::.
Human   484 IGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVG----FQSNNI 544

  Fly   507 GLQANMFISNEPGFYQDGEFGIRVEDIVQIVPGQVAHNFSNRGALTFKTITMCPKQTKMIKKELL 571
            .:...||.|.|||:|:|||||||:||:..:|..:..:..|   .|||:.::..|....:|...||
Human   545 AMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGS---YLTFEVVSFVPYDRNLIDVSLL 606

  Fly   572 SDAEVKLLNSYHQQVWDTLSPILSREG--DEFTLSWLKKEVQPI 613
            |...::.||.|:|.:.:.:.|.|.|..  :||  .||::..:|:
Human   607 SPEHLQYLNRYYQTIREKVGPELQRRQLLEEF--EWLQQHTEPL 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473	68/144 (47%)
		Creatinase_N_2	158..318	CDD:318430	51/176 (29%)
		APP	321..545	CDD:238518	114/223 (51%)
		Peptidase_M24_C	551..613	CDD:318429	19/63 (30%)
XPNPEP2	NP_003390.4	Creatinase_N	54..184	CDD:279639	64/137 (47%)
		Creatinase_N_2	202..361	CDD:292807	49/169 (29%)
		PepP	<348..601	CDD:223085	126/260 (48%)
		APP	365..583	CDD:238518	114/222 (51%)
		Peptidase_M24_C	585..648	CDD:292806	19/64 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62675
OrthoDB	1	1.010	-	-		D265764at33208
OrthoFinder	1	1.000	-	-		FOG0001510
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100896
Panther	1	1.100	-	-	O	PTHR43763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1687
SonicParanoid	1	1.000	-	-		X1075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860