Protein Alignment ApepP and XPNPEP1

DIOPT Version :9

• Sequence 1: NP_001246053.1
• Gene: ApepP / 35029
• FlyBaseID: FBgn0026150
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: NP_001311062.1
• Gene: XPNPEP1 / 7511
• HGNCID: 12822
• Length: 695
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 290/601 - (48%)
• Similarity: 401/601 - (66%)
• Gaps: 24/601 - (3%)

  Fly     5 TTQILTRLRELMLRAQVGDSCGISAYIVPSDDAHQSEYQCQHDERRSFVSGFDGSAGTAVITTET 69
            |:::|.:||:.|..::.... .|.|||:||.|||||||....|.||:||||||||||||:||.|.
Human    49 TSELLRQLRQAMRNSEYVTE-PIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEH 112

  Fly    70 ALLWTDGRYYQQAEKQLDSNWVLMRDGLSATPSIGAWLAKNLPKGSFVGVDPRLLSFRVWKPIET 134
            |.:||||||:.||.||:||||.||:.||..||:...||...||:||.|||||.::....||.:..
Human   113 AAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAK 177

  Fly   135 ELSSAECQLVPIEGNLIDEVWGEDQPPQTSNKIITLKLEHSGVTIAKKWDVVRQQLKEKNADALV 199
            .|.||...|:|::.||:|::| .|:|.:....::||.|:::|::...|...:|.::.|:|....|
Human   178 VLRSAGHHLIPVKENLVDKIW-TDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFV 241

  Fly   200 VSALDEIAWFLNLRGSDIDFNPVFFSYLIVTNDELLLFVDSGKLPTDFVQHQ------KENNVQI 258
            |:|||||||..||||||::.|||||||.|:..:.::||:|..::....|:..      .|...:|
Human   242 VTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLLLDLGLEAEYRI 306

  Fly   259 SVLPYASIGIEISKI---VSTRESKIWIAPTSSYYLTALIPKSRR-IQEVTPICVLKAIKNDVEI 319
            .|.||.||..|:..:   :|.|| |:|::..:||.::..|||..| ....||||:.||:||..|.
Human   307 QVHPYKSILSELKALCADLSPRE-KVWVSDKASYAVSETIPKDHRCCMPYTPICIAKAVKNSAES 370

  Fly   320 AGFINSHIRDGVALCQYFAWLEDQVNKGAEVDEMSGADKLESFRSTKDKYMGLSFTTISASGPNG 384
            .|...:||:|.||||:.|.|||.:|.||. |.|:|.|||.|.||..:..::.|||.|||::||||
Human   371 EGMRRAHIKDAVALCELFNWLEKEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNG 434

  Fly   385 SVIHYHPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHFGEPTEFQKEAYTRVLKGQLSFGS 449
            ::|||.|..||||.::..|:||.||||||.|||||||||:|||.||.::||.:|.||||.::..:
Human   435 AIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSA 499

  Fly   450 TVFPAKVKGQVLDTLARKALWDVGLDYGHGTGHGVGHFLNVHEGPMGVGIRLMPDDPGLQANMFI 514
            .|||...||.:||:.||.||||.||||.||||||||.||||||||.|:..:...|:| |:|.|.:
Human   500 AVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEP-LEAGMIV 563

  Fly   515 SNEPGFYQDGEFGIRVEDIVQIVPGQVAHNFSNRGALTFKTITMCPKQTKMIKKELLSDAEVKLL 579
            ::|||:|:||.||||:|::|.:||.:..:||:|||:|||:.:|:.|.|||||..:.|:|.|
Human   564 TDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKE---- 624

  Fly   580 NSYHQQVWDTLSPILS 595
                 ::|:.:.|..|
Human   625 -----ELWNGILPARS 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473	77/144 (53%)
		Creatinase_N_2	158..318	CDD:318430	64/169 (38%)
		APP	321..545	CDD:238518	125/223 (56%)
		Peptidase_M24_C	551..613	CDD:318429	16/45 (36%)
XPNPEP1	NP_001311062.1	Creatinase_N	53..197	CDD:304957	77/144 (53%)
		Creatinase_N_2	207..369	CDD:292807	62/162 (38%)
		PepP	239..609	CDD:223085	189/372 (51%)
		APP	372..594	CDD:238518	125/223 (56%)
		Peptidase_M24_C	600..>627	CDD:292806	13/35 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141180
Domainoid	1	1.000	253	1.000	Domainoid score	I2087
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6424
Inparanoid	1	1.050	589	1.000	Inparanoid score	I998
Isobase	1	0.950	-	0	Normalized mean entropy	S1084
OMA	1	1.010	-	-		QHG62675
OrthoDB	1	1.010	-	-		D265764at33208
OrthoFinder	1	1.000	-	-		FOG0001510
OrthoInspector	1	1.000	-	-		oto89757
orthoMCL	1	0.900	-	-		OOG6_100896
Panther	1	1.100	-	-	LDO	PTHR43763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1687
SonicParanoid	1	1.000	-	-		X1075
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750