DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ApepP and xpnpep3

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_996962.1	Gene:	xpnpep3 / 573360	ZFINID:	ZDB-GENE-040426-2076	Length:	510	Species:	Danio rerio

Alignment Length:	505	Identity:	115/505 - (22%)
Similarity:	190/505 - (37%)	Gaps:	145/505 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 VWKPIETELSSAECQLVPIEGNLIDEVWGEDQPPQ---------TSNKIITLKLEHSGVT---IA 180
            ||.|         |:.|.::    .|.|...:.||         |...:|    .|..||   ..
Zfish    26 VWCP---------CRHVSVK----TEGWNSKKVPQRYLGQPSPYTHPHLI----RHGEVTPGLTQ 73

  Fly   181 KKWDVVRQQLKEKNADALVVSALDEIAWFLNLRGSDIDFNPVFFSYLIVTNDELLLFVDSGKLPT 245
            .::::.||:|    |..:.:.|..:       .||....|.   |::::.....:.:: |..:|.
Zfish    74 TEYELRRQRL----ASLIEIQAERQ-------TGSGASSNS---SHIVIILSHPIRYM-SNDIPY 123

  Fly   246 DFVQHQKENNVQI--------SVLPYASIGIEISKIVSTRES---KIWIAPTSSYYLTALIPKSR 299
            .|  ||.::.:.:        :::.|.|...:.:.:...|..   ::|..|.|.....|.:....
Zfish   124 PF--HQNQDFLYLTGITEPDSALVMYGSSKPDQAVLFVPRRDPARELWDGPRSGKDGAAALTGLE 186

  Fly   300 RIQEVTPI-CVLKAIKNDVEIAGFINS----------HIR---DGVALCQYFAWLEDQ---VNKG 347
            |:.....: .|||:||...  ..:.||          |:|   :|..|.:....|...   :...
Zfish   187 RVHSTEELGVVLKSIKGGT--VWYDNSQPCHQRLHQTHVRPLLEGGQLVKSLRPLTHSLRAIKSP 249

  Fly   348 AEVDEMSGADKL--ESFRSTKDKYMG----------------------LSFTTISASGPNGSVIH 388
            |||..|..|.::  ::|:.|.....|                      |::..:.|.|...:.:|
Zfish   250 AEVALMKEAGRITAQAFKKTMAMSRGNIDEAVLYAKFDYECRAHGANFLAYPPVVAGGNRANTLH 314

  Fly   389 YHPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHF-GEPTEFQKEAYTRVLKGQLSFGSTVF 452
            |   ...|:.:.|.|:.|.|.|.:|....:|:|||... |:.:..|:|.|..||:.||:..|...
Zfish   315 Y---INNNQIVKDGEMVLLDGGCEYFGYVSDITRTWPVNGKFSAAQRELYEAVLEVQLACLSQCS 376

  Fly   453 PAKVKGQVLD-------TLARKALWDVGLDYGHGTG------------HGVGHFL--NVHEGPMG 496
            |    |..||       ||..:.|.::|:...|.:.            |.|||:|  :||:.|
Zfish   377 P----GVSLDYIYSTMLTLLARQLKELGIVPSHASDTDAMKAARQFCPHHVGHYLGMDVHDTP-- 435

  Fly   497 VGIRLMPDDPGLQANMFISNEPGFY--QDGE--------FGIRVEDIVQI 536
               .|....| ||..|.|:.|||.|  :|..        .|:|:||.|.|
Zfish   436 ---ELSRSQP-LQPGMVITIEPGLYISEDNRSCPERFRGLGVRIEDDVVI 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473	5/25 (20%)
		Creatinase_N_2	158..318	CDD:318430	34/183 (19%)
		APP	321..545	CDD:238518	74/288 (26%)
		Peptidase_M24_C	551..613	CDD:318429
xpnpep3	NP_996962.1	PRK10879	71..508	CDD:182804	101/443 (23%)
		AMP_N	71..209	CDD:198079	27/156 (17%)
		Prolidase	252..492	CDD:238520	65/243 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810