DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ApepP and PEPD

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_000276.2	Gene:	PEPD / 5184	HGNCID:	8840	Length:	493	Species:	Homo sapiens

Alignment Length:	449	Identity:	96/449 - (21%)
Similarity:	164/449 - (36%)	Gaps:	154/449 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 RQQLKEKNA--DALVVSALDEIA---------WFLNLRGSDIDFNPVFFSYLIVTNDELLLF-VD 239
            ::..|||.|  |   |..:||||         ..|.|||.:.|...|...   .:.|.:..| |:
Human   114 KEHFKEKYAVDD---VQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCRE---ASFDGISKFEVN 172

  Fly   240 SGKLPTDFVQHQK-ENNVQISVLPYASIGIEISKIVSTRESKIWIAPTSSYYLTALIPKSRRIQE 303
            :..|..:.|:.:. :.::::.||.|.      :||.|....:
Human   173 NTILHPEIVECRVFKTDMELEVLRYT------NKISSEAHRE----------------------- 208

  Fly   304 VTPICVLKAIKNDVEIAGFINSHIRDGVALCQYFAWLEDQVNKGAEVDEMSGADKLESFRSTKDK 368
                 |:||:|                |.:.:|            |::.:     .|.:..::..
Human   209 -----VMKAVK----------------VGMKEY------------ELESL-----FEHYCYSRGG 235

  Fly   369 YMGLSFTTISASGPNGSVIHY-HPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHF-GEPTE 431
            ....|:|.|..||.|.:|:|| |.....:|.|.:.::.|.|.|.:|....:|:|.:... |:.|.
Human   236 MRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTA 300

  Fly   432 FQKEAYTRVLKGQLSFGSTVFPA-------KVKGQV-LDTLARKALWDVGLD---YGH-GT---G 481
            .||..|..||:...:....:.|.       ::..:: |:.||...:....:|   ..| |.   .
Human   301 DQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMP 365

  Fly   482 HGVGHFL--NVHE-GPMGVGIRLMPDDPG---------LQANMFISNEPGFY----------QD- 523
            ||:||||  :||: |....|:..: |:||         ||..|.::.|||.|          .|
Human   366 HGLGHFLGIDVHDVGGYPEGVERI-DEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADP 429

  Fly   524 ---------------GEFGIRVEDIVQIVPGQVAHNFSNRGALTFKTITMCPKQTKMIK 567
                           |..|:|:|:.|.:....:            :.:|..|:..:.|:
Human   430 ARASFLNREVLQRFRGFGGVRIEEDVVVTDSGI------------ELLTCVPRTVEEIE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473
		Creatinase_N_2	158..318	CDD:318430	31/143 (22%)
		APP	321..545	CDD:238518	62/278 (22%)
		Peptidase_M24_C	551..613	CDD:318429	3/17 (18%)
PEPD	NP_000276.2	AMP_N	18..155	CDD:198079	15/43 (35%)
PEPD	NP_000276.2	Prolidase	192..467	CDD:238520	72/354 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810