DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ApepP and SPAC22G7.01c

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001342933.1	Gene:	SPAC22G7.01c / 2541673	PomBaseID:	SPAC22G7.01c	Length:	598	Species:	Schizosaccharomyces pombe

Alignment Length:	606	Identity:	270/606 - (44%)
Similarity:	377/606 - (62%)	Gaps:	17/606 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTRLRELMLRAQVGDSCGISAYIVPSDDAHQSEYQCQHDERRSFVSGFDGSAGTAVITTETALLW 73
            |.:|||||...      |.:.|:|||:|||.|||.|..|.||:|:||||||||.|||...:|.|:
pombe     9 LNKLRELMKER------GYTLYVVPSEDAHSSEYTCDADARRAFISGFDGSAGCAVIGETSAALF 67

  Fly    74 TDGRYYQQAEKQLDSNWVLMRDGLSATPSIGAWLAKNLPKGSFVGVDPRLLSFRVWKPI-ETELS 137
            |||||:.||.:|||.||.||:.|.:..|:...:..:.......||:|..|::|...|.: |:...
pombe    68 TDGRYFNQASQQLDENWTLMKQGFTGVPTWEEYCTQMTKCNEKVGIDSSLITFPAAKALRESLFL 132

  Fly   138 SAECQLVPIEGNLIDEVWGEDQPPQTSNKIITLKLEHSGVTIAKKWDVVRQQLKEKNADALVVSA 202
            .:...||....||:|.|||..:|.:...|:|..:::::|:.:.:|...:|:.:||:..:|.|||.
pombe   133 KSGAVLVGDHDNLVDIVWGASRPKEPLEKLIVQEIKYAGLGVDEKLHNLREAMKEQKIEAFVVSM 197

  Fly   203 LDEIAWFLNLRGSDIDFNPVFFSYLIVTNDELLLFVDSGKLPTDFVQHQKENNVQISVLPYASIG 267
            |||:||..||||:|:.:|||||:|.:||.||..|:||..|:..:..:|.   :..:.:|||..:
pombe   198 LDEVAWLYNLRGADVPYNPVFFAYSLVTLDEAFLYVDERKVTPEVSKHL---DGFVKILPYDRV- 258

  Fly   268 IEISKIVSTRESKIWIAPTSSYYLTALIPKSRRIQEVTPICVLKAIKNDVEIAGFINSHIRDGVA 332
              .|...::..::|.|:..:|:.:.....:::.:..::||...|.||||.|:.|....|||||.|
pombe   259 --FSDAKNSNLTRIGISSKTSWCIATSFGETKVMPILSPISQAKGIKNDAELKGMKECHIRDGCA 321

  Fly   333 LCQYFAWLEDQVNKGAEVDEMSGADKLESFRSTKDKYMGLSFTTISASGPNGSVIHYHPKKETNR 397
            |.:|||||::.:|.|.:::|...|.|||.||...:.:|||||.|||::||||:||||.|....:.
pombe   322 LVEYFAWLDEYLNSGNKINEFDAATKLEQFRRKNNLFMGLSFETISSTGPNGAVIHYSPPATGSA 386

  Fly   398 KINDKEIYLCDSGAQYLDGTTDVTRTLHFGEPTEFQKEAYTRVLKGQLSFGSTVFPAKVKGQVLD 462
            .|:..:||||||||||.|||||||||.|||||:||:::..|..|||.::..:.|||....|.::|
pombe   387 IIDPTKIYLCDSGAQYKDGTTDVTRTWHFGEPSEFERQTATLALKGHIALANIVFPKGTTGYMID 451

  Fly   463 TLARKALWDVGLDYGHGTGHGVGHFLNVHEGPMGVGIRLMPDDPGLQANMFISNEPGFYQDGEFG 527
            .|||:.||..||||.||||||||.||||||.|:|:|.|.:.:...|||.|..|||||||:||.||
pombe   452 VLARQYLWKYGLDYLHGTGHGVGSFLNVHELPVGIGSREVFNSAPLQAGMVTSNEPGFYEDGHFG 516

  Fly   528 IRVEDIVQIVPGQVAHNFSNRGALTFKTITMCPKQTKMIKKELLSDAEVKLLNSYHQQVWDTLSP 592
            .|||:.|.|......:.|:.|..|..|.:|:.|...|:|...|||..|||.||.||.:|:.||||
pombe   517 YRVENCVYITEVNTENRFAGRTYLGLKDLTLAPHCQKLIDPSLLSPEEVKYLNEYHSEVYTTLSP 581

  Fly   593 ILSREGDEFTLSWLKKEVQPI 613
            :||....:    ||.|...||
pombe   582 MLSVSAKK----WLSKHTSPI 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473	63/145 (43%)
		Creatinase_N_2	158..318	CDD:318430	51/159 (32%)
		APP	321..545	CDD:238518	122/223 (55%)
		Peptidase_M24_C	551..613	CDD:318429	26/61 (43%)
SPAC22G7.01c	NP_001342933.1	Creatinase_N	8..147	CDD:329087	62/143 (43%)
		Creatinase_N_2	154..307	CDD:318430	51/158 (32%)
		APP	310..534	CDD:238518	122/223 (55%)
		Peptidase_M24_C	538..598	CDD:318429	26/63 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	243	1.000	Domainoid score	I443
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6424
Inparanoid	1	1.050	517	1.000	Inparanoid score	I224
OMA	1	1.010	-	-		QHG62675
OrthoFinder	1	1.000	-	-		FOG0001510
OrthoInspector	1	1.000	-	-		oto101149
orthoMCL	1	0.900	-	-		OOG6_100896
Panther	1	1.100	-	-	LDO	PTHR43763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1687
SonicParanoid	1	1.000	-	-		X1075
TreeFam	1	0.960	-	-
	14	13.860