DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ApepP and R119.2

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_490725.3	Gene:	R119.2 / 187899	WormBaseID:	WBGene00020088	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	424	Identity:	89/424 - (20%)
Similarity:	155/424 - (36%)	Gaps:	119/424 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 FSYLI-VTNDELLLFVDSGKLPTDFVQHQKENNVQISVLPYASIGIEISKIVSTRES---KIW-- 282
            |.||. :|..:....:.||     ..:..||.|:                :.:.|.|   ::|
Worm    68 FRYLNGITTPDCYYIMQSG-----ISESSKETNI----------------LFADRRSAYDELWEG 111

  Fly   283 IAPTSSYY-----LTALIPKSRRIQEVTPIC------------------VLKAIKNDV-EIAGFI 323
            ..||.|.:     .|..:|.||.:|.:..:|                  .::|..|.| ||..||
Worm   112 ALPTESEWEKTAKFTECVPTSRILQTLEKVCDKGTAVFFDSTSDDLLYKFVQAKANSVREINHFI 176

  Fly   324 NSHIRDGVALCQYFAWLEDQVNKGAEV--DEMSGADKLESFRSTKDKYMGL-------------S 373
            ..  |..:......:.:.|..|.||:.  ..:||:..|.:    ::...||             :
Worm   177 ER--RRVIKSPSEMSSMRDVCNVGAQTMSSMISGSRDLHN----ENAICGLLEFEGRRRGSEMQA 235

  Fly   374 FTTISASGPNGSVIHYHPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHF-GEPTEFQKEAY 437
            :..:.|.|...:.|||   .:.|..:|.:|..|.|:|.......:||||.... |..::.|...|
Worm   236 YPPVIAGGVRANTIHY---LDANNDLNPRECVLVDAGCDLNGYVSDVTRCFPISGFWSDAQLSLY 297

  Fly   438 TRVL---KGQLSFGSTVFPAKVKG--QVLDTLARKALWDVGL-------DYGHGT----GHGVGH 486
            ..:|   :..|::..::...::..  :.::.|...:..::||       :..|..    .|.|.|
Worm   298 EALLYVHEELLTYAHSMEKVRLSALFRRMNELLAASFTELGLIRSTDHKEMIHQAEKLCPHHVSH 362

  Fly   487 FL--NVHEGPMGVGIRLMPDDPGLQANMFISNEPGFYQDGEF--------GIRVEDIVQIVPGQV 541
            :|  :||:.|      .:..|..|..|:..:.|||.|...::        |.|:||.|..
Worm   363 YLGMDVHDCP------TVSRDIDLPPNVPFTIEPGVYVPMDWPVKEFRGIGYRIEDDVAT----- 416

  Fly   542 AHNFSNRGALTFKTITMCPKQTKMIKKELLSDAE 575
                |..|.:...|..: |:....|:: |:..||
Worm   417 ----SEAGGIELLTAAV-PRDPIEIQR-LMGTAE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473
		Creatinase_N_2	158..318	CDD:318430	24/123 (20%)
		APP	321..545	CDD:238518	55/265 (21%)
		Peptidase_M24_C	551..613	CDD:318429	6/25 (24%)
R119.2	NP_490725.3	AMP_N	20..149	CDD:377484	21/101 (21%)
R119.2	NP_490725.3	APP_MetAP	188..427	CDD:381919	54/260 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810