DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ApepP and Pepd

DIOPT Version :9

Sequence 1:	NP_001246053.1	Gene:	ApepP / 35029	FlyBaseID:	FBgn0026150	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_032846.2	Gene:	Pepd / 18624	MGIID:	97542	Length:	493	Species:	Mus musculus

Alignment Length:	242	Identity:	69/242 - (28%)
Similarity:	104/242 - (42%)	Gaps:	52/242 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 SFTTISASGPNGSVIHY-HPKKETNRKINDKEIYLCDSGAQYLDGTTDVTRTLHF-GEPTEFQKE 435
            |:|.|..||.|.:|:|| |.....:|.|.|.:|.|.|.|.:|....:|:|.:... |:.||.||.
Mouse   240 SYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTEDQKA 304

  Fly   436 AYTRVLKGQLSFGSTVFPA-------KVKGQV-LDTLARKALW----DVGLDYGHGT---GHGVG 485
            .|..||:...:..||:.|.       ::..:: |:.|||..|.    |..|....|.   .||:|
Mouse   305 IYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELARIGLLSGSVDAMLQVHLGAVFMPHGLG 369

  Fly   486 HF--LNVHE-GPMGVGIRLMPDDPGLQA---------NMFISNEPGFYQDGEFGIRVEDIVQIVP 538
            ||  |:||: |....|:..: |:|||::         .|.::.|||.|    |...:.|.....|
Mouse   370 HFLGLDVHDVGGYPEGVERI-DEPGLRSLRTARHLEPGMVLTVEPGIY----FIDHLLDQALADP 429

  Fly   539 GQ-------VAHNFSNRGALT-----------FKTITMCPKQTKMIK 567
            .|       |...|.|.|.:.           .:.:|..|:..:.|:
Mouse   430 AQACFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLTCVPRTVEEIE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ApepP	NP_001246053.1	Creatinase_N	9..154	CDD:307473
		Creatinase_N_2	158..318	CDD:318430
		APP	321..545	CDD:238518	63/207 (30%)
		Peptidase_M24_C	551..613	CDD:318429	3/28 (11%)
Pepd	NP_032846.2	AMP_N	23..138	CDD:282980
		PepP	52..476	CDD:223085	68/240 (28%)
		Prolidase	192..467	CDD:238520	66/231 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0006
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810