DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and HNRNPDL

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_112740.1	Gene:	HNRNPDL / 9987	HGNCID:	5037	Length:	420	Species:	Homo sapiens

Alignment Length:	293	Identity:	63/293 - (21%)
Similarity:	111/293 - (37%)	Gaps:	64/293 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 AKANAN-NKDEEGVKRIRNPAEEASTVFVGNLPINTKRVQLVKLFQPYGLVQSIRLRT---AGGK 192
            :|.||: |:.::|            .:|:|.|..:|.:..|.:....:|.|....::|   .|..
Human   136 SKINASKNQQDDG------------KMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRS 188

  Fly   193 QLFKHKQRKVAGSLNAYVVLEKPEI------AQQALALNGSEFKENHLRVTPASMAEKFGQAKDK 251
            :.|.....|.|.|::..:.|::.::      .::|.||.|                        |
Human   189 RGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKG------------------------K 229

  Fly   252 QPSDKDAKRTIFVGSLKYSATEEQLREIFSSCGEIDYIRCLQDGDKG-CKGVAYVCFQKPDAVGL 315
            :|..|     :|||.|....:|||::|.|.:.|||:.|....|.... .:|..::.:...:.|..
Human   230 EPPKK-----VFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKK 289

  Fly   316 ALELNQTLLDDRPINVERYQVKKLGAKQVRD-----AAAASAASKTSSKTKAKNQN-SAGAKKRL 374
            .||.....:......::..|.|::..:|.:.     .|||.....|..:.:.:.|| :.|.....
Human   290 LLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYY 354

  Fly   375 DKKKGKENGSLKKEGAPTGQKKKSEYRGVKVDG 407
            |:..|..|      .|..|.:..|.|.|....|
Human   355 DQGYGNYN------SAYGGDQNYSGYGGYDYTG 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	18/90 (20%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	18/71 (25%)
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..120
		RRM1_hnRPDL	149..224	CDD:410152	14/74 (19%)
		RRM2_hnRPDL	234..308	CDD:409998	19/78 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..348		7/34 (21%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269\|PubMed:9524220	342..420		12/46 (26%)
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910