DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and HRB1

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_014394.2	Gene:	HRB1 / 855728	SGDID:	S000004949	Length:	454	Species:	Saccharomyces cerevisiae

Alignment Length:	297	Identity:	63/297 - (21%)
Similarity:	105/297 - (35%)	Gaps:	75/297 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 EEGVKRIRNPAEEASTVFVGNLPINTKRVQLVKLFQPYGLVQSIRLRTAGGKQLFKHKQRKVAGS 205
            ||.|.|     ..::::|||||..::....|.:.|...|.|....:.|:.|    .|:      .
Yeast   152 EEKVNR-----NYSNSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITSRG----HHR------G 201

  Fly   206 LNAYVVLEKPEIAQQALALNGSEFKENHLRV----TPASMAEKFGQAKDKQPSDKDAK-RTIFVG 265
            :.........::.:.....:|:.|.:..:.|    .|.|...|..:|.|:.....:.| ..:.|.
Yeast   202 MGTVEFTNSDDVDRAIRQYDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVK 266

  Fly   266 SLKYSATEEQLREIFSSCGEIDYIRCLQDGDKGCKGVAYVCF----------QKPDAVGLALELN 320
            :|..|...:.|::||..||.:.:.....|||....|...|.|          :|.:  |.::|.|
Yeast   267 NLPASVNWQALKDIFKECGNVAHADVELDGDGVSTGSGTVSFYDIKDLHRAIEKYN--GYSIEGN 329

  Fly   321 -------------------QTLLDDRPINVE--RYQVKKLGAKQVRDAAAASAASKTSSK----- 359
                               ...:||.|:|.|  ::....:|..:.......|....:::|
Yeast   330 VLDVKSKESVHNHSDGDDVDIPMDDSPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSDLYD 394

  Fly   360 ---TKAKNQNSAGAKKRLDKKKGKENGSLKKEGAPTG 393
               |..|..|   |:.|.|.|           |||||
Yeast   395 LFETIGKVNN---AELRYDSK-----------GAPTG 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	15/85 (18%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	22/99 (22%)
HRB1	NP_014394.2	PRK12678	<29..>85	CDD:237171
		RRM1_HRB1_GBP2	160..236	CDD:410184	15/85 (18%)
		RRM2_HRB1_GBP2	262..334	CDD:410185	18/73 (25%)
		RRM3_HRB1_GBP2	374..452	CDD:410186	14/58 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910