DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and NOP12

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_014601.1	Gene:	NOP12 / 854116	SGDID:	S000005401	Length:	459	Species:	Saccharomyces cerevisiae

Alignment Length:	485	Identity:	123/485 - (25%)
Similarity:	189/485 - (38%)	Gaps:	153/485 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DEVKAAVQESPKKLSAKDLAKIEKKKAKKQAQKLKKQQNKLAPKEIKTEPEAQVKVESKATKKEK 111
            ||.|  ::.|..||.:.....|.|.:.|.:.:       .:.|...|.|..|:...|.|...|..
Yeast    13 DEKK--IESSVDKLFSSSCGPINKLEVKSKTR-------TVLPDSKKRERAAEADQEEKEASKPD 68

  Fly   112 VEKEPTTAPNEK---PKGKVSKKAKANANNKDEEG---VKRIRNPAE------------EAS--- 155
            |..|.|    |:   ||.|.:||:|.|..::|.|.   .|.:...||            |.|
Yeast    69 VSDEQT----EEVALPKVKKAKKSKRNDEDEDLEARYYAKLLNEEAEAEDDKPTVTKTDETSVPL 129

  Fly   156 -------------------TVFVGNL---PINTKRV--QLVKLF--QPYG--------------- 179
                               |||:||:   .|.:|:|  :..|||  .|..
Yeast   130 TSAAKKVDFKEDELEKAERTVFIGNILSTVITSKKVYKEFKKLFGTNPIAETEESGNEKEEESSK 194

  Fly   180 -------LVQSIRLRT-----------AGGKQLFKHKQRKVAGSLNAYVVLE-KPEIAQQALALN 225
                   .::|||.|:           |..:|.| ||.|   .::|||:|.: |..:.:....||
Yeast   195 KSDNNEFAIESIRFRSISFDEALPRKVAFVQQKF-HKSR---DTINAYIVYKNKSAVRKICSNLN 255

  Fly   226 GSEFKENHLRVTPASMAEKFGQAKDKQPSDKDAKRTIFVGSLKYSATEEQLREIFSSCGEIDYIR 290
            ...|:::||||...:           .|:..|.||:||||:|.:...||.|.:.|..||:|:|:|
Yeast   256 AVVFQDHHLRVDSVA-----------HPAPHDKKRSIFVGNLDFEEIEESLWKHFEPCGDIEYVR 309

  Fly   291 CLQDGDKGC-KGVAYVCFQKPDAVGLALELNQTLLDDRPINVERYQ----------VKKL---GA 341
            .::|..... ||.|||.|:...:|..||     ||:::|:..::.:          .:||   ..
Yeast   310 IIRDSKTNMGKGFAYVQFKDLQSVNKAL-----LLNEKPMKSQKQEDENTKKPTKKARKLRVSRC 369

  Fly   342 KQVRDAAAASAASKTSSKTKAKNQNSAGAKKRLDK-----------------KKGKENGSL--KK 387
            |.::...........:..|.::...:..|||.|.|                 |||:.:..|  ||
Yeast   370 KNMKKGTTIGTGLDRNGLTDSQRTRAGRAKKILGKADRATLGQEITIEGLRAKKGEGSTHLKKKK 434

  Fly   388 EGAPTGQKKKSEYRGVKVDGIKKAKKPKKK 417
            :.:.||:..|   |.:   ..|||:..|.|
Yeast   435 QRSATGRVTK---RSI---AFKKAQAEKSK 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	34/144 (24%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	27/71 (38%)
NOP12	NP_014601.1	RRM1_Nop12p_like	148..272	CDD:410070	34/138 (25%)
NOP12	NP_014601.1	RRM2_Nop12p_like	280..370	CDD:410071	29/94 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1599
Isobase	1	0.950	-	0	Normalized mean entropy	S2864
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004008
OrthoInspector	1	1.000	-	-		oto99829
orthoMCL	1	0.900	-	-		OOG6_103046
Panther	1	1.100	-	-	O	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R827
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.900