DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and TIA1

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_071505.2	Gene:	TIA1 / 7072	HGNCID:	11802	Length:	386	Species:	Homo sapiens

Alignment Length:	243	Identity:	58/243 - (23%)
Similarity:	96/243 - (39%)	Gaps:	63/243 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EEASTVFVGNLPINTKRVQLVKLFQPYGLVQSIR--LRTAGGKQ---LFKHKQRKVAGSLNAYVV 211
            |...|::||||..:.....:::||...|..::.:  :.|||...   :..|:.|..|.:|
Human     4 EMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAAL----- 63

  Fly   212 LEKPEIAQQALALNGSEFKENHLRV----TPASMAEKFGQAKDKQPSD-KDAKRT-----IFVGS 266
                      .|:||.:.....::|    ||:|      |.||...|. ...:|:     :|||.
Human    64 ----------AAMNGRKIMGKEVKVNWATTPSS------QKKDTSSSTVVSTQRSQDHFHVFVGD 112

  Fly   267 LKYSATEEQLREIFSSCGEIDYIRCLQDGDKG-CKGVAYVC-FQKPDAVGLALELNQTLLDDRPI 329
            |....|.|.::..|:..|.|...|.::|...| .||..:|. |.|.||...
Human   113 LSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENA-------------- 163

  Fly   330 NVERYQVKKLGAKQVRD--AAAASAASKTSSKTKAK--------NQNS 367
             :::...:.||.:|:|.  |.....|.|::.::..|        ||:|
Human   164 -IQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSS 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	19/90 (21%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	19/77 (25%)
TIA1	NP_071505.2	RRM1_TIA1	8..81	CDD:410027	19/87 (22%)
		RRM2_TIA1	104..181	CDD:410030	23/91 (25%)
		RRM3_TIAR	214..286	CDD:241064
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910