Protein Alignment CG12288 and Spen

DIOPT Version :9

• Sequence 1: NP_609822.1
• Gene: CG12288 / 35027
• FlyBaseID: FBgn0032620
• Length: 435
• Species: Drosophila melanogaster
• Sequence 2: XP_038966732.1
• Gene: Spen / 690911
• RGDID: 1589867
• Length: 3632
• Species: Rattus norvegicus
• Alignment Length: 567
• Identity: 115/567 - (20%)
• Similarity: 197/567 - (34%)
• Gaps: 171/567 - (30%)

  Fly     4 PKAKESEKAE----------LKPIKKEPGVVEDGKVTKK--SKTKPKKKTVKVP--KD--EVKAA 52
            |.|..:||||          .:|.:..| |:|:.|:..:  |::..::|.|.:.  ||  :..|.
  Rat  1646 PPAAAAEKAEETSEAPSLAGERPEEPTP-VLEETKLVSEPPSESVEQRKQVDLSPGKDSHDSTAV 1709

  Fly    53 VQESPKKLSAKDLAKIEKKKAKKQAQKLKKQQNKLAPKEIKTEPEAQVKVESKATKKEKVEKEPT 117
            |..:|.:.:..|.......:.......:.:.::...||....:|.:::....:..::.|||:..|
  Rat  1710 VASTPPESTTTDTVPCVDAEPLTPGTTVSQVESSADPKPSSPQPPSKLTQRCEEAEEPKVERPET 1774

  Fly   118 TA-------------PNEKPKGKVSKKAKANANNKDEEGVKRIRN----PAEEASTVFVGNLPIN 165
            ||             |..:|......:|......||.:..|..|:    ||..||.|   ..|:.
  Rat  1775 TASIEPDATEKAEVVPEVQPPASEDVEASPPVTAKDRKTTKSKRSKTSVPAAAASIV---EKPVT 1836

  Fly   166 TK-----RVQLVKLFQPYGLVQSIR---------LRTA----GGK--------QLFKHKQRKVAG 204
            .|     |.::.:...|.|..|.:.         .|||    ||.        .|.:.::|.|.
  Rat  1837 RKSERIDREKMKRSSSPRGEAQKLLELKMEADKVTRTASKSSGGDTEHPEPSLPLSRTRRRNVR- 1900

  Fly   205 SLNAYVVL-------------EKPEIAQQALALNGSEFKENHLR---VTPAS-----------MA 242
              :.|..:             |:|.:.::.|        |..|:   |.||:           ..
  Rat  1901 --SVYATMGDHESRSPAKEPTEQPRVTRKRL--------ERELQEAVVVPATPRRGRPPKTRRRV 1955

  Fly   243 EKFGQAKDKQPSD--KDAKRTIFVGSLKYSAT---------EEQLREIFSSCGEIDYIRCLQDGD 296
            |:.|:.:.|:|:|  :.|:......|.|.:||         .|...|...:..::.    .::|:
  Rat  1956 EEGGEQERKEPADTPRPAEGRRSPRSQKLAATGGPQGKRGRNEHRAEAAEATAQVS----AREGN 2016

  Fly   297 KGCKGVAYVCFQKPDAVGLALELNQTLLDDR------------PINVER------YQVKKLGAKQ 343
            ...:|.....             ::|..|.:            |:.|||      |:.|:..|:.
  Rat  2017 AKARGDREAA-------------SETRRDRKDPSTDKDGPDIFPVEVERKPPEKTYKSKRGRARS 2068

  Fly   344 VR---DAA--------AASAASKTSSKTKA---KNQN---SAGAKKRL-------DKKKGKENGS 384
            .|   |.|        |..||.|.:....|   ||::   .:|...:|       ||:..||:.|
  Rat  2069 TRSGMDRAAHLKSLEMARQAADKEAEPVAASPEKNESPLEGSGVSPQLADNPADPDKEAEKESVS 2133

  Fly   385 LKKEGAPTGQKKKSEYRGVKVDGIKKAKKPKKKSNDQQTALAKKIAP 431
            .........|..|.......|:.|.|..:|...:.|:.||.|....|
  Rat  2134 ASTVSPEARQLTKQMELQQAVENIAKLAEPSAAAADKGTATATSEEP 2180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	22/123 (18%)
		RRM_SF	261..332	CDD:302621	11/91 (12%)
Spen	XP_038966732.1	RRM1_SHARP	7..81	CDD:409784
		RRM2_SHARP	336..409	CDD:409785
		RRM3_SHARP	436..509	CDD:409786
		RRM4_SHARP	510..586	CDD:409787
		RRM	<512..671	CDD:223796
		PTZ00121	<773..1252	CDD:173412
		PTZ00449	<1529..1983	CDD:185628	71/351 (20%)
		PTZ00121	<1760..>2333	CDD:173412	92/452 (20%)
		PHA03247	<2178..2711	CDD:223021	1/3 (33%)
		Collagen_mid	<2630..>2723	CDD:406398
		Herpes_BLLF1	<2669..3118	CDD:282904
		PHA03247	<3081..3468	CDD:223021
		SPOC	3469..3632	CDD:400205

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910