DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and RBM4

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_002887.2	Gene:	RBM4 / 5936	HGNCID:	9901	Length:	364	Species:	Homo sapiens

Alignment Length:	345	Identity:	64/345 - (18%)
Similarity:	106/345 - (30%)	Gaps:	141/345 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 VFVGNLPINTKRVQLVKLFQPYGLV--------------------------------QSIRLRTA 189
            :|:||||......::..||:.||.|                                ..:.:...
Human     4 LFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINVE 68

  Fly   190 GGKQLFKHKQRKVAGSLN---------------------------AYVVLEKPEIAQQAL-ALNG 226
            ..|...|...:...|:::                           |:|.:|:.|.|.:|: .|:.
Human    69 ASKNKSKTSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDN 133

  Fly   227 SEFKENHLRV--------TPASMAE--------KFGQAKDKQPSDKD---------------AKR 260
            :||:...:.|        |...|.:        |.|....:.|.|:.               |.|
Human   134 TEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVR 198

  Fly   261 TIFV----GSLKYSATEEQLREIFSSCGEID--YIRCLQDGDKGCKGVA-----------YVCFQ 308
            |.:.    .||.|:          ::.|.:|  |.||  ...:..:.||           ....|
Human   199 TPYTMSYGDSLYYN----------NAYGALDAYYKRC--RAARSYEAVAAAAASVYNYAEQTLSQ 251

  Fly   309 KPDA--VGLALELNQTLLDDRPINVERYQVKKLGAKQVRDAAAASAASKTSSKTKAKNQNSAGAK 371
            .|..  ..:|..|..|.||.    .:|:.:...||.....||||:||:.|::.|
Human   252 LPQVQNTAMASHLTSTSLDP----YDRHLLPTSGAAATAAAAAAAAAAVTAAST----------- 301

  Fly   372 KRLDKKKGKENGSLKKEGAP 391
                ...|::...|::..||
Human   302 ----SYYGRDRSPLRRATAP 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	23/147 (16%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	18/89 (20%)
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	10/63 (16%)
		RRM2_RBM4	78..144	CDD:410019	10/65 (15%)
		PTZ00368	<145..>181	CDD:173561	6/35 (17%)
		ZnF_C2HC	161..176	CDD:197667	2/14 (14%)
		Interaction with TNPO3. /evidence=ECO:0000269\|PubMed:12628928	196..364		35/153 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910