DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12288 and RBM28

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_060547.2	Gene:	RBM28 / 55131	HGNCID:	21863	Length:	759	Species:	Homo sapiens

Alignment Length:	620	Identity:	122/620 - (19%)
Similarity:	225/620 - (36%)	Gaps:	211/620 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KTPKAKESEKAELKP------------------------------IKKEP-------------GV 23
            |.||||:::.|:.|.                              |.::|             .:
Human   100 KEPKAKKAKVADKKARLIIRNLSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNL 164

  Fly    24 VEDGKVTKKSKTKP-KKKTV----KVPKDEVKAAVQESPKKLSAKDLAKIEKKKAKKQAQKLKKQ 83
            :|.||..|....|. |.:||    .|.||:.|     ..:.:||....|..:.|.::..:|..::
Human   165 LEAGKALKGMNMKEIKGRTVAVDWAVAKDKYK-----DTQSVSAIGEEKSHESKHQESVKKKGRE 224

  Fly    84 QNKLAPKE--------------IKTEPEAQVKVESKATKKEKVEKEPTTAPNEKPKGKVSKK--- 131
            :..:..:|              ...|.|.:..:|||.||..:::|.....|........|::
Human   225 EEDMEEEENDDDDDDDDEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSD 289

  Fly   132 -------------AKANANNKDEE-------GVKRIRNPAE--EASTVFVGNLPINTKRVQLVKL 174
                         |:::.:.:::|       ..|:.:.|::  |..|||:.||..:::..:|.:|
Human   290 LEESDSIDDGEELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGEL 354

  Fly   175 FQPYGLVQSIRL---------------------------------RTAGG--------------- 191
            .|.:|.::.:|:                                 ..|||
Human   355 LQQFGELKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVT 419

  Fly   192 ----KQLFKHKQRKVAGSLNAYVVLEKPEIAQQALALNGSEFKENHLRVTPASMA--EKFGQAKD 250
                .:|...|.:|..|:.|.|       :|::.|...|::..|.   |:.|.||  |:|...|.
Human   420 RDEAAKLQTTKVKKPTGTRNLY-------LAREGLIRAGTKAAEG---VSAADMAKRERFELLKH 474

  Fly   251 KQPSDKDAKRTIFVG-------SLKYSATEEQLREIFSSC--GE----IDYIRCLQD-----GD- 296
            ::..|::    |||.       :|..:..::|||::..|.  ||    |...|.::|     |:
Human   475 QKLKDQN----IFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNM 535

  Fly   297 KG-CKGVAYVCFQKPDAVGLALEL----------------NQTLLDDRPINVERYQVKKLGAKQV 344
            || ..|.|:..||:.:....||.|                ..:|.|.|.:.::..:::: ..:::
Human   536 KGQSLGYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQR-SLQKM 599

  Fly   345 RDAAAASAASKTSSKTKAKNQNSAGAKKRLDKKKGKENGSLKKEGAP--TGQKKKSEYRGVKVDG 407
            |...|.....| .....||:|....|:...:::........:|.|:.  ||.:.|:|...|::..
Human   600 RSKPATGEPQK-GQPEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVELPD 663

  Fly   408 IKKAKK---------PKKKSNDQQTALAKKIAPKQ 433
            .||.:|         ||.:..|:  ...|.:.||:
Human   664 GKKRRKVLALPSHRGPKIRLRDK--GKVKPVHPKK 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	23/133 (17%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	26/106 (25%)
RBM28	NP_060547.2	RRM1_RBM28_like	5..81	CDD:240859
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..105		3/4 (75%)
		RRM2_RBM28_like	115..190	CDD:240860	10/74 (14%)
		RRM	126..721	CDD:330708	115/594 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..330		20/128 (16%)
		RRM3_RBM28_like	335..417	CDD:240861	13/81 (16%)
		RRM4_RBM28_like	487..581	CDD:240862	21/93 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..759		23/107 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910